Retinoblastoma: The pRB Story Quiz

Play an AI-generated podcast conversation about this lesson

Which type of gene can be activated or gain function within a cell, leading to genomic instability and eventually cancer?

Oncogenes (correct)

Apoptosis genes

DNA repair genes

Tumour suppressor genes

What happens when tumour suppressor genes are lost or oncogenes are activated?

Uncontrolled cellular growth (correct)

Enhanced DNA repair

Reduced metastasis

Decreased angiogenesis

What is the result of angiogenesis in a developing tumour?

Enhanced immune response against the tumour

Decreased growth of the tumour

Development of its own blood supply (correct)

Reduction in metastasis

What is metastasis in the context of cancer?

When a primary tumour enters blood vessels and spreads around the body (D) Signup and view all the answers

What contributes to genomic instability in a cell?

Activation of oncogenes or loss of function of tumour suppressor genes (B) Signup and view all the answers

What is the role of tumour suppressor genes in the development of cancer?

Their deactivation leads to genomic instability and cancer development (C) Signup and view all the answers

What is the function of the hTERT (Telomerase) gene in cancer cells?

Maintains telomeres in cells (C) Signup and view all the answers

What is a common early symptom of retinoblastoma in children?

Discolouration in one of the child’s eyes (A) Signup and view all the answers

What percentage of retinoblastoma cases are bilateral (occur in both eyes)?

40% (D) Signup and view all the answers

Which treatment type involves using a hot probe to burn the cancer cells?

Thermotherapy (C) Signup and view all the answers

In the context of tumour suppression, what did Sir Henry Harris propose was central to carcinogenesis?

Chromosome loss (B) Signup and view all the answers

What was the conclusion drawn from the fusion of highly malignant mouse cell line with a mouse cell line of lower malignancy by Barski & et al (1962)?

Malignancy must be dominant (C) Signup and view all the answers

What is the main role of the P16 gene in cancer?

Regulates Retinoblastoma (C) Signup and view all the answers

What is the primary age of diagnosis for retinoblastoma in children?

~2 years old (B) Signup and view all the answers

Which gene is responsible for regulating retinoblastoma?

$P16$ gene (D) Signup and view all the answers

What is the function of Telomerase in cancer cells?

Maintains telomeres in cells (B) Signup and view all the answers

What is the main function of the hTERT gene in cancer cells?

Maintains telomeres in cells (D) Signup and view all the answers

What did Sir Henry Harris propose was central to carcinogenesis in the context of tumour suppression?

Chromosome loss (C) Signup and view all the answers

What contributes to genomic instability in a cell according to the text?

Gain of genetic information (C) Signup and view all the answers

What is the primary age of diagnosis for retinoblastoma in children?

2 years old (B) Signup and view all the answers

What is metastasis in the context of cancer?

Spread of cancer to other parts of the body (C) Signup and view all the answers

Which treatment type involves using liquid nitrogen to freeze and kill cancer cells?

Cryotherapy (C) Signup and view all the answers

What is a common early symptom of retinoblastoma in children according to the text?

Discolouration in the eyes (B) Signup and view all the answers

What happens when tumour suppressor genes are lost or oncogenes are activated?

Genomic instability (C) Signup and view all the answers

What is the result of angiogenesis in a developing tumour?

Formation of blood vessels within a tumour (A) Signup and view all the answers

What is the relationship between oncogenes and tumour suppressor genes in terms of genomic instability?

Oncogenes can be activated, leading to genomic instability, while tumour suppressor genes can be deactivated, also leading to genomic instability (A) Signup and view all the answers

What is the process of angiogenesis in the context of cancer development?

It is the formation of a primary tumour's own blood supply (D) Signup and view all the answers

What is metastasis in the context of cancer?

It is when a primary tumour spreads to other parts of the body and forms secondary tumours (B) Signup and view all the answers

What contributes to genomic instability in a cell, leading to cancer development?

Both activation of oncogenes and deactivation of tumour suppressor genes (A) Signup and view all the answers

Which statement accurately describes the role of tumour suppressor genes in cancer development?

Deactivation of tumour suppressor genes leads to uncontrolled cellular growth, angiogenesis, and metastasis (A) Signup and view all the answers

What happens when oncogenes are activated or gain function within a cell?

It leads to genomic instability and eventually contributes to cancer development (D) Signup and view all the answers

Retinoblastoma: The pRB Story Quiz

Choose a study mode

Podcast

Questions and Answers

Which type of gene can be activated or gain function within a cell, leading to genomic instability and eventually cancer?

What happens when tumour suppressor genes are lost or oncogenes are activated?

What is the result of angiogenesis in a developing tumour?

What is metastasis in the context of cancer?

What contributes to genomic instability in a cell?

What is the role of tumour suppressor genes in the development of cancer?

What is the function of the hTERT (Telomerase) gene in cancer cells?

What is a common early symptom of retinoblastoma in children?

What percentage of retinoblastoma cases are bilateral (occur in both eyes)?

Which treatment type involves using a hot probe to burn the cancer cells?

In the context of tumour suppression, what did Sir Henry Harris propose was central to carcinogenesis?

What was the conclusion drawn from the fusion of highly malignant mouse cell line with a mouse cell line of lower malignancy by Barski & et al (1962)?

What is the main role of the P16 gene in cancer?

What is the primary age of diagnosis for retinoblastoma in children?

Which gene is responsible for regulating retinoblastoma?

What is the function of Telomerase in cancer cells?

What is the main function of the hTERT gene in cancer cells?

What did Sir Henry Harris propose was central to carcinogenesis in the context of tumour suppression?

What contributes to genomic instability in a cell according to the text?

What is the primary age of diagnosis for retinoblastoma in children?

What is metastasis in the context of cancer?

Which treatment type involves using liquid nitrogen to freeze and kill cancer cells?

What is a common early symptom of retinoblastoma in children according to the text?

What happens when tumour suppressor genes are lost or oncogenes are activated?

What is the result of angiogenesis in a developing tumour?

What is the relationship between oncogenes and tumour suppressor genes in terms of genomic instability?

What is the process of angiogenesis in the context of cancer development?

What is metastasis in the context of cancer?

What contributes to genomic instability in a cell, leading to cancer development?

Which statement accurately describes the role of tumour suppressor genes in cancer development?

What happens when oncogenes are activated or gain function within a cell?

More Like This

OCULISTICA - 10. Patologie pediatriche : Retinoblastoma

Retinoblastoma

Retinoblastoma Overview

Retinoblastoma and RB1 Gene Quiz