5 Questions
What type of tumor does retinoblastoma encode proteins to suppress?
Malignant tumor arising from immature neurons in the retina
What percentage of retinoblastoma cases are associated with a germline mutation?
40%
What evidence supports the existence of tumor suppressor genes?
Cell fusion studies showing a normal cell fused to a tumor cell produces a nontumorigenic hybrid cell
What happens if an affected child inherits one defective Rb allele and the remaining normal Rb allele is inactivated?
Development of retinoblastoma
What is the percentage of new germline mutations in Drosophila (fruit fly) for suppressor genes?
20-30%
Test your knowledge of retinoblastoma, a rare malignant tumor, and its association with tumor suppressor genes. Explore the genetics, inheritance patterns, and the role of mutation in this condition.
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