Respiratory System Functions and Lung Capacities

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Questions and Answers

What is the primary difference between compliance and elastance in respiratory physiology?

  • Compliance and elastance are synonymous terms with no significant difference.
  • Elastance is only relevant in diseases affecting lung capacity.
  • Compliance refers to the ability to stretch but elastance refers to the ability to return to its original shape. (correct)
  • Compliance is the ability to recoil, while elastance is the ability to stretch.

How do surfactants influence surface tension in the alveoli?

  • Surfactants reduce surface tension to help stabilize the alveoli. (correct)
  • Surfactants increase surface tension, which is necessary for lung expansion.
  • Surfactants only affect surface tension in the bronchi.
  • Surfactants have no effect on surface tension.

Which factor is most significant in affecting airway resistance?

  • Viscosity of the air
  • Temperature of the air
  • Radius of the airway (correct)
  • Length of the airway

What is the effect of bronchoconstriction on airway resistance?

<p>It increases resistance by partly closing the airways. (A)</p> Signup and view all the answers

What initiates bronchodilation in the respiratory system?

<p>Binding of epinephrine to B2 receptors. (B)</p> Signup and view all the answers

What is the role of local control mechanisms in ventilation and blood flow?

<p>They ensure perfusion is matched to alveolar ventilation for optimal gas exchange. (B)</p> Signup and view all the answers

What happens to blood flow when ventilation decreases in a group of alveoli?

<p>Vasoconstriction occurs upstream to prioritize oxygenation. (B)</p> Signup and view all the answers

What is the typical dead space volume in the lungs?

<p>150 ml (D)</p> Signup and view all the answers

How is total pulmonary ventilation calculated?

<p>As the product of ventilation rate and tidal volume. (C)</p> Signup and view all the answers

What role does the diaphragm play during inspiration?

<p>It contracts to increase thoracic volume. (A)</p> Signup and view all the answers

Which volume represents the air that remains in the lungs after maximal exhalation?

<p>Residual volume (D)</p> Signup and view all the answers

What is the main function of the protective mechanism of the respiratory system?

<p>To protect from inhaled pathogens. (A)</p> Signup and view all the answers

How does intrapleural pressure contribute to normal lung function?

<p>It is normally sub-atmospheric to maintain lung inflation. (C)</p> Signup and view all the answers

What defines the total lung capacity?

<p>The combination of all lung volumes. (C)</p> Signup and view all the answers

During expiration, what happens to alveolar pressure?

<p>It increases as thoracic volume decreases. (C)</p> Signup and view all the answers

Which capacity is defined as the sum of expiratory reserve volume and residual volume?

<p>Functional residual capacity (B)</p> Signup and view all the answers

When does alveolar pressure reach its highest point during a respiratory cycle?

<p>Halfway through inspiration. (B)</p> Signup and view all the answers

Which statement correctly explains the tidal volume?

<p>It is the volume of air moved during normal, restful breathing. (C)</p> Signup and view all the answers

What is the effect of decreasing thoracic volume during expiration?

<p>It results in an increase in alveolar pressure. (B)</p> Signup and view all the answers

Flashcards

Compliance in Respiratory Physiology

The ability of the lungs to stretch and expand when air is inhaled. It's a measure of how easily the lungs can change volume in response to pressure changes.

Elastance in Respiratory Physiology

The ability of the lungs to return to their original shape and size after being stretched. It describes the lungs' tendency to recoil.

Surface Tension in Alveoli

The force that occurs at the surface of water lining the alveoli, causing them to want to collapse.

Surfactant's Role

A substance produced by the lungs that reduces surface tension, preventing the alveoli from collapsing and ensuring stability.

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Bronchoconstriction

The narrowing of the airways, increasing resistance to airflow. It occurs due to muscle contraction in the airways.

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Bronchodilation

The widening of the airways, decreasing resistance to airflow. It is achieved through muscle relaxation in the airways.

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Factors Affecting Airway Resistance

Factors such as airway radius, bronchoconstriction, and bronchodilation play a significant role in determining how easily air flows through the airways.

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Total Pulmonary Ventilation

The total amount of air that moves in and out of the lungs per minute. It is calculated by multiplying ventilation rate by tidal volume.

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Alveolar Ventilation

The amount of fresh air that reaches the alveoli per minute. Dead space volume (the volume of air not participating in gas exchange) is subtracted from the tidal volume.

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Local Control of Ventilation-Perfusion Matching

The body adjusts blood flow to different parts of the lungs to match the ventilation in those areas, ensuring efficient gas exchange.

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What are the four major functions of the respiratory system?

The respiratory system performs four key tasks: 1) exchanging gases between the atmosphere and blood; 2) regulating body pH; 3) protecting from inhaled pathogens; and 4) enabling vocalization.

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Tidal Volume (VT)

The normal volume of air inhaled and exhaled during a quiet breath at rest.

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Inspiratory Reserve Volume

The extra volume of air you can breathe in beyond the tidal volume. This is a deeper, forceful inhalation.

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Expiratory Reserve Volume

The extra volume of air you can exhale beyond the tidal volume.

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Residual Volume

The air that remains in your lungs even after a maximal exhalation. You can't exhale all the air.

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Functional Residual Capacity

The amount of air left in the lungs after a normal exhalation. It combines the expiratory reserve volume and the residual volume.

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Total Lung Capacity

The sum of all lung volumes, including the tidal volume, inspiratory reserve volume, expiratory reserve volume, and residual volume.

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Vital Capacity

The amount of air you can exhale after a maximal inhalation. It's all volumes excluding the residual volume.

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Intrapleural Pressure

The pressure within the pleural cavity surrounding the lungs. This pressure is normally negative, helping to keep the lungs inflated.

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How do pressures and lung volumes change during breathing?

During inspiration, the diaphragm contracts, increasing thoracic volume and decreasing alveolar pressure, causing air to flow in. During expiration, the diaphragm relaxes, decreasing thoracic volume, increasing alveolar pressure, and causing air to flow out.

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Study Notes

Respiratory System Functions

  • Four major functions:
    • Gas exchange between atmosphere and blood
    • Homeostatic regulation of body pH
    • Protection from inhaled pathogens
    • Vocalization

Lung Volumes and Capacities

  • Tidal volume (VT): Normal breathing volume at rest
  • Inspiratory reserve volume: Volume breathed beyond tidal volume during a deep breath
  • Expiratory reserve volume: Extra volume exhaled beyond tidal volume
  • Residual volume: Air remaining in lungs after maximal exhalation (cannot be exhaled)
  • Capacities: Combinations of two or more volumes
    • Functional residual capacity (FRC): Air remaining in the lungs after a normal exhalation (Expiratory reserve volume + Residual volume)
    • Total lung capacity (TLC): The sum of all lung volumes
    • Vital capacity (VC): The maximum amount of air that can be exhaled after a maximum inhalation (Inspiratory reserve volume + Tidal volume + Expiratory reserve volume)

Spirometer Tracing

  • Visual representation of lung volumes and capacities
  • Shows the different phases of inhalation and exhalation
  • Illustrates the various volumes (tidal, inspiratory reserve, expiratory reserve, residual) and capacities (inspiratory capacity, vital capacity, total lung capacity, functional residual capacity)

Pressure and Lung Volumes During Breathing

  • Inspiration: Alveolar pressure decreases, thoracic volume increases (due to diaphragm contraction)
  • Expiration: Diaphragm relaxes, thoracic volume decreases, alveolar pressure increases

Intrapleural Pressure

  • Sub-atmospheric pressure
  • Keeps lungs inflated (-3 mm Hg)
  • Pleural cavity: sealed compartment

Alveolar and Intrapleural Pressure Changes

  • Alveolar pressure is always greater than intrapleural pressure to inflate lungs
  • Intrapleural pressure has greater oscillation
  • Lowest pressure point in alveoli: halfway through inspiration
  • Highest pressure point in alveoli: halfway through expiration

Lung Compliance and Elastance

  • Compliance: Ability to stretch
  • Elastance: Ability to return to normal (recoil)

Surface Tension and Surfactants

  • Surface tension: Due to water lining alveoli surface
  • Surfactants: Reduce surface tension, ensuring alveoli stability

Airway Resistance

  • Radius: Largest factor affecting airway resistance; affects bronchoconstriction/dilation
  • Bronchoconstriction: Increased resistance (caused by parasympathetic stimulation, binding to muscarinic receptors, closes airway)
  • Bronchodilation: Decreased resistance (caused by sympathetic stimulation, binding to B2 receptors, opens airway)

Ventilation and Alveolar Blood Flow Matching

  • Perfusion of blood matched to alveolar ventilation for efficient gas exchange
  • Decreased ventilation in a region leads to increased CO2, decreased O2, causing vasoconstriction to divert blood to better-ventilated areas

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