Respiratory Physiology Quiz
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Questions and Answers

What is the typical ventilatory pattern seen in lung fibrosis?

  • Mixed pattern with reduced FEV1%, but normal TLC
  • Obstructive pattern with normal TLC, FEV1, and FVC
  • Restrictive pattern with reduced TLC, FEV1, and FVC (correct)
  • Normal pattern with increased FEV1%, but reduced FVC

    • Why does hypoxemia occur in advanced IPF according to the text?

  • Related to normal capillary transit time in fibrotic areas
  • Due to even airflow distribution in the lungs
  • Resulting from stable regional compliance in fibrosis
  • Caused by significant mismatching in regional ventilation (correct)

    • How is diffusion impairment related to resting hypoxemia in lung fibrosis?

  • Diffusion impairment contributes significantly to resting hypoxemia
  • Diffusion impairment does not affect resting hypoxemia (correct)
  • Diffusion impairment only affects exercise-induced desaturation
  • Diffusion impairment completely resolves resting hypoxemia

    • What is the usual arterial PCO2 in lung fibrosis patients according to the text?

    <p>Low because of increased ventilation</p> Signup and view all the answers

    Why does cardiac output tend to be low in advanced IPF according to the text?

    <p>Resulting from fibrotic obliteration of lung capillaries</p> Signup and view all the answers

    How does diffusion impairment contribute to exercise-induced desaturation in lung fibrosis?

    <p>By limiting oxygen loading of hemoglobin with increased capillary transit time</p> Signup and view all the answers

    What is the normal ratio of FEV1/FVC?

    <p>4/5</p> Signup and view all the answers

    In a person with obstructive lung disease, which of the following is likely to be reduced?

    <p>FEV1</p> Signup and view all the answers

    In pulmonary arterial hypertension, what is the characteristic change in the pulmonary arteries?

    <p>Pruning</p> Signup and view all the answers

    What is the term for the amount of air that remains in the lungs after normal expiration?

    <p>RV</p> Signup and view all the answers

    In a person with restrictive lung disease, which of the following is likely to be reduced?

    <p>TLC</p> Signup and view all the answers

    What is the term for the amount of air that can be exhaled rapidly and forcefully after a full inspiration?

    <p>FEV1</p> Signup and view all the answers

    What is the primary implication of hypercapnia?

    <p>Inability to maintain adequate alveolar ventilation</p> Signup and view all the answers

    In a normal lung, how long does it take for hemoglobin to become completely saturated with oxygen?

    <p>0.25 seconds</p> Signup and view all the answers

    What happens to the mixed venous PO2 in the setting of exercise?

    <p>It decreases</p> Signup and view all the answers

    What is the effect of lung fibrosis on the alveolar–capillary barrier?

    <p>It thickens the barrier</p> Signup and view all the answers

    What is the typical transit time for an erythrocyte through an alveolar capillary?

    <p>0.75 seconds</p> Signup and view all the answers

    What happens to alveolar end-capillary blood in the setting of lung fibrosis and shortened capillary transit time?

    <p>It becomes partially saturated with oxygen</p> Signup and view all the answers

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