Respiratory Function Techniques
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Questions and Answers

What is the primary function of the respiratory system?

  • To detoxify harmful substances
  • To aid in digestion
  • To regulate body temperature
  • To oxygenate blood (correct)

Which of the following techniques measures the volume of air taken in and expelled from the lungs?

  • Arterial Blood Gas
  • Spirometer (correct)
  • DLCO
  • Pulse Oximetry

What does the Helium Dilution Method specifically measure?

  • Rate of carbon dioxide elimination
  • Volume of gas in the lungs (correct)
  • Alveolar gas exchange efficiency
  • Oxygen levels in the blood

What is a key aspect of gas exchange in the lungs?

<p>Blood flow through the lung is unidirectional (A)</p> Signup and view all the answers

Which component is essential for measuring ventilatory function?

<p>Quantification of gas volume in the lungs (D)</p> Signup and view all the answers

In the context of respiratory function, what is a common diagnostic tool for evaluating oxygen saturation in the blood?

<p>Pulse Oximetry (B)</p> Signup and view all the answers

What occurs at the lung alveoli during respiration?

<p>Diffusion and equilibration of respiratory gases (D)</p> Signup and view all the answers

Which outcome is specifically evaluated through pulmonary function tests?

<p>Airway resistance (A)</p> Signup and view all the answers

What does the Forced Vital Capacity (FVC) represent?

<p>Amount of gas exhaled after a maximal inspiration (B)</p> Signup and view all the answers

What is the approximate Total Lung Capacity (TLC) for men?

<p>6 liters (A)</p> Signup and view all the answers

Which components make up the Vital Capacity (VC)?

<p>Inspiratory Reserve Volume, Tidal Volume, and Expiratory Reserve Volume (B)</p> Signup and view all the answers

After completing the forced expiration down to Residual Volume (RV), what is the next step in the Forced Vital Capacity maneuver?

<p>Forcefully inspire back to Total Lung Capacity (TLC) (C)</p> Signup and view all the answers

What combination of lung volume is referred to as Functional Residual Capacity?

<p>Expiratory Reserve Volume and Residual Volume (D)</p> Signup and view all the answers

Which of the following parameters is classified as a volume parameter in spirometry?

<p>Forced Vital Capacity (FVC) (D)</p> Signup and view all the answers

What is the role of Inspiratory Reserve Volume (IRV) in lung capacity calculations?

<p>It contributes to the calculation of Vital Capacity (B)</p> Signup and view all the answers

Which statement correctly describes the function of the Vital Capacity (VC) maneuver?

<p>It measures the amount of gas that can be expired following deep inhalation (D)</p> Signup and view all the answers

What characterizes the flow volume loop during mid-inspiration?

<p>A U-shaped inspiratory loop (C)</p> Signup and view all the answers

During which phase is the flow rate most rapid?

<p>During mid-inspiration (B)</p> Signup and view all the answers

What type of obstruction presents a scooped-out pattern on the expiratory part of the flow volume loop?

<p>Lower obstruction distal to the mainstem bronchus (D)</p> Signup and view all the answers

What happens to the flow rate at total lung capacity (TLC)?

<p>It is zero (C)</p> Signup and view all the answers

Which axis of the flow volume loop is primarily affected in obstructive lung defects?

<p>Y-axis representing flow rate (D)</p> Signup and view all the answers

How does a restrictive defect alter the flow volume loop?

<p>Reduces both flow and volume representation (A)</p> Signup and view all the answers

What would likely indicate an upper obstruction in the flow volume loop?

<p>Flattening of the inspiratory and/or expiratory portions (C)</p> Signup and view all the answers

In what manner does expiration flow rate behave in obstructive lung defects?

<p>It increases to a peak and then decreases (D)</p> Signup and view all the answers

What is the tidal volume (TV)?

<p>The amount of air that enters and exits the lungs during normal quiet breathing. (A)</p> Signup and view all the answers

What does the inspiratory reserve volume (IRV) refer to?

<p>The additional air that can be inspired after normal tidal inspiration. (B)</p> Signup and view all the answers

How is expiratory reserve volume (ERV) defined?

<p>The additional air that can be expelled after normal tidal expiration. (C)</p> Signup and view all the answers

What is residual volume (RV)?

<p>The air remaining in the lungs after maximal expiration. (C)</p> Signup and view all the answers

What is the definition of inspiratory capacity (IC)?

<p>The combination of inspiratory reserve volume and tidal volume. (D)</p> Signup and view all the answers

What constitutes the functional residual capacity (FRC)?

<p>The sum of expiratory reserve volume and residual volume. (C)</p> Signup and view all the answers

During the forced vital capacity maneuver, what is the correct sequence of actions?

<p>Inhale maximally to total lung capacity, then exhale forcefully to residual volume. (B)</p> Signup and view all the answers

What is the purpose of measuring lung volumes and capacities?

<p>To evaluate respiratory function and diagnose lung conditions. (D)</p> Signup and view all the answers

What is the approximate volume of fresh air inspired with each breath?

<p>500 mL (B)</p> Signup and view all the answers

What does the Alveolar-Articular O2 Difference depend on?

<p>Hemoglobin concentration (A)</p> Signup and view all the answers

How is PAO2 calculated?

<p>PAO2 = [FiO2 x (PB - P H2O)] – (PaCO2 / R) (C)</p> Signup and view all the answers

What is the value of FiO2 at room air?

<p>0.21 (B)</p> Signup and view all the answers

Which factor influences the percentage of hemoglobin saturated with O2?

<p>PaO2 (D)</p> Signup and view all the answers

What is the assumed respiratory quotient (R) used in PAO2 calculations?

<p>0.8 (A)</p> Signup and view all the answers

What constitutes the Alveolar-Arterial Gradient?

<p>Calculated PAO2 minus measured PaO2 (C)</p> Signup and view all the answers

What is the water vapor pressure (P H2O) when air is fully saturated at 37 C?

<p>47 mmHg (A)</p> Signup and view all the answers

What is a limitation of using a pulse oximeter when the PaO2 is above 60 mmHg?

<p>It becomes less sensitive to changes in PaO2. (B)</p> Signup and view all the answers

In what condition might pulse oximeter readings become unreliable due to decreased cutaneous perfusion?

<p>Low cardiac output states (D)</p> Signup and view all the answers

Why are carboxyhemoglobin and methemoglobin problematic when measuring oxygen saturation with a pulse oximeter?

<p>They are indistinguishable from oxyhemoglobin at two wavelengths of light. (B)</p> Signup and view all the answers

Which of the following disease processes is associated with decreased diffusing capacity (DLCO)?

<p>Interstitial lung disease (A)</p> Signup and view all the answers

What physiological change can lead to an unreliable pulse oximeter reading in a patient with recurrent pulmonary emboli?

<p>Decreased x-sectional area of the pulmonary vascular bed (A)</p> Signup and view all the answers

Which condition is likely to cause elevated DLCO?

<p>Asthma exacerbation (B)</p> Signup and view all the answers

What effect does hyperventilation and low PaCO2 have on blood gases?

<p>It raises PAO2 and PaO2. (C)</p> Signup and view all the answers

What could cause a pulse oximeter to provide an unobtainable signal?

<p>Low perfusion states (A)</p> Signup and view all the answers

Flashcards

Respiratory System Function

The primary function is to oxygenate blood and eliminate carbon dioxide.

Lung Volumes & Capacities

Measurements of the amount of air in the lungs at different points during breathing.

Pulmonary Function Test (PFT) or Spirometry

A test that measures how much air a person can breathe in and out of their lungs.

Gas Exchange

The process of oxygen and carbon dioxide moving between the air in the lungs and the blood.

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Spirometer

A machine that measures lung volumes.

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Helium Dilution Method

A method used to measure lung volumes by introducing helium gas.

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Ventilation

Process of air moving in and out of the lungs.

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Alveoli

Tiny air sacs in the lungs where gas exchange takes place.

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Tidal Volume (TV)

The amount of air inhaled and exhaled during a normal breath.

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Inspiratory Reserve Volume (IRV)

The extra air that can be inhaled after a normal breath.

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Expiratory Reserve Volume (ERV)

The extra air that can be exhaled after a normal breath.

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Residual Volume (RV)

The air remaining in the lungs after a maximum exhalation.

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Inspiratory Capacity (IC)

The maximum amount of air that can be inhaled after a normal exhalation.

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Functional Residual Capacity (FRC)

The amount of air remaining in the lungs after a normal exhalation.

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Total Lung Capacity (TLC)

The sum of all lung volumes (TV, IRV, ERV, and RV).

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Forced Vital Capacity

The maximum volume of air that can be forcefully exhaled after a maximum inhalation.

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Vital Capacity (VC)

The maximum amount of air that can be exhaled after taking a full, deep breath.

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Forced Vital Capacity (FVC)

The total amount of air that can be forcibly exhaled after a full inspiration.

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Forced Expiratory Volume in 1 second (FEV1)

The amount of air that can be forcefully exhaled in the first second of a forced expiration.

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FEV1/FVC Ratio

The proportion of the FVC exhaled in the first second, expressed as a percentage.

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Inspiratory Capacity

The amount of air that can be inhaled after a normal tidal expiration.

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Functional Residual Capacity

The amount of air remaining in the lungs after a normal tidal expiration; the sum of ERV and RV.

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Forced Vital Capacity Maneuver

A respiratory test where the patient takes a deep breath, forcibly exhales completely, then inhales fully again and repeats some tidal breaths.

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Alveolar Oxygen Tension (PaO2)

The partial pressure of oxygen in the arterial blood, reflecting the oxygen content of the blood leaving the lungs.

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Oxygen Saturation (SaO2)

The percentage of hemoglobin in the blood that is bound to oxygen.

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How does PaO2 affect SaO2?

PaO2 determines what percentage of hemoglobin is saturated with oxygen based on the oxyhemoglobin dissociation curve.

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What is the Alveolar-Arterial Oxygen Difference (A-a gradient)?

The difference between the partial pressure of oxygen in the alveoli (PAO2) and the partial pressure of oxygen in the arterial blood (PaO2).

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How do you calculate PAO2?

PAO2 = [FiO2 x (PB – P H2O)] – (PaCO2/ R), where FiO2 is the fraction of inspired oxygen, PB is barometric pressure, P H2O is water vapor pressure, PaCO2 is partial pressure of carbon dioxide in arterial blood, and R is respiratory quotient.

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Why is the A-a gradient important?

It helps determine how well oxygen is diffusing from the alveoli into the blood. A larger A-a gradient indicates a problem with oxygen transfer.

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What factors affect the A-a gradient?

The A-a gradient is influenced by factors such as hemoglobin concentration, PaO2, and the efficiency of gas exchange in the lungs.

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How is the A-a gradient calculated?

It is calculated by subtracting the measured PaO2 from the calculated PAO2.

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Flow Volume Loop

A graphical representation of airflow (y-axis) against lung volume (x-axis) during a forced inspiration and expiration.

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Normal Inspiratory Loop

The shape of the flow-volume loop during a normal inspiration, characterized by a rapid increase in flow rate during mid-inspiration, resulting in a U-shaped curve.

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Obstructive Lung Defect

A condition that affects the flow rate and causes a reduction in the volume of air that can be exhaled quickly.

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Lower Obstruction

An obstructive lung defect located distal to the mainstem bronchus, characterized by a scooped-out expiratory pattern on the flow-volume loop.

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Upper Obstruction

An obstructive lung defect located proximal to the mainstem bronchus, characterized by flattening on the inspiratory and/or expiratory portions of the flow-volume loop.

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Restrictive Ventilatory Defect

A condition that primarily affects lung volume, causing a decrease in the volume of air that can be inhaled and exhaled.

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What part of the flow-volume loop is affected in Obstructive Lung Defect?

The flow rate (y-axis) is primarily affected in obstructive lung defects. It might be affected since the obstructions make it harder to move air quickly.

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How does the flow-volume loop appear in Obstructive Lung Defect?

The flow-volume loop in obstructive lung defects tends to be shorter due to the decreased flow rate caused by the obstruction. Additionally, lower obstructions will show a scooped-out pattern on the expiratory part of the loop.

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Oximeter Insensitivity

The oximeter becomes less reliable when PaO2 (partial pressure of oxygen in arterial blood) is above 60 mmHg (90% saturation). This is because the oxyhemoglobin dissociation curve flattens, making the oximeter less sensitive to changes in PaO2 above this level.

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Decreased Cutaneous Perfusion

Conditions like low cardiac output or vasoconstrictors can make the oximeter signal unreliable or unobtainable because they reduce blood flow to the fingertip where the sensor is placed.

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Hemoglobin Derivatives

Oximeters are inaccurate in the presence of carboxyhemoglobin (COHb) or methemoglobin (MetHb) because these forms of hemoglobin aren't distinguishable from oxyhemoglobin by the oximeter's light wavelengths.

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DLCO

Diffusion capacity of the lung for carbon monoxide (DLCO) measures how well gases move from the alveoli into the blood. It's a sensitive indicator of lung function.

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Interstitial Lung Disease

Interstitial lung disease causes scarring in the alveolar capillary units, reducing the surface area for gas exchange and lowering DLCO.

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Emphysema

Emphysema destroys alveolar walls, reducing surface area for gas exchange and lowering DLCO.

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Pulmonary Vascular Disease

Pulmonary vascular disease (like recurrent pulmonary emboli or primary pulmonary hypertension) decreases the blood vessels' cross-sectional area and volume in the lungs, lowering DLCO.

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Elevated DLCO

DLCO can be elevated in conditions like polycythemia (high red blood cell count), where there's more hemoglobin available for gas transport.

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Study Notes

Respiratory Function Disturbances

  • Measurements of ventilatory function quantify gas volume in lungs and the rate of gas expulsion.
  • Ventilation is the process of replacing alveolar gas.
  • Perfusion is the delivery of blood to the alveoli.
  • Adequate diffusion between alveolar gas and capillary blood is necessary for successful oxygenation and CO2 removal.

Respiratory Function Techniques

  • Spirometry: Measures the volume of air inhaled and exhaled.
  • Helium Dilution Method: A technique using helium to calculate lung volumes. Possible underestimation of lung volume if bullae (air pockets) are present.

Lung Volumes and Capacities

  • Tidal Volume (TV): The amount of air inhaled and exhaled during normal breathing.
  • Inspiratory Reserve Volume (IRV): Additional air that can be inhaled after normal inspiration.
  • Expiratory Reserve Volume (ERV): Additional air that can be exhaled after a normal expiration.
  • Residual Volume (RV): Amount of air in the lungs after maximal exhalation; approximately 20% of total lung capacity.
  • Inspiratory Capacity (IC): Sum of TV and IRV.
  • Functional Residual Capacity (FRC): Sum of ERV and RV.
  • Vital Capacity (VC): Sum of IRV, TV, and ERV.
  • Total Lung Capacity (TLC): Sum of all lung volumes.

Body Plethysmography

  • Measures lung volumes by assessing pressure changes in a sealed box.
  • Measures lung volume by measuring pressure changes when the patient pants against a closed mouthpiece.

Breathing Maneuvers

  • Forced Vital Capacity (FVC): The total volume of air exhaled forcefully after a maximal inspiration.
  • Forced Expiratory Volume in 1 second (FEV1): The volume exhaled in the first second of forced exhalation.
  • FEV1/FVC ratio: The ratio of FEV1 to FVC, a measure of how quickly air is expelled.

Flow-Volume Loops

  • Graphical representation of FVC and FEV1 data.
  • Useful for differentiating obstructive and restrictive lung diseases.
    • Obstructive patterns show scooped-out expiratory portions.
    • Restrictive patterns are thin and tall.

Components of a Spirometry Report

  • Includes demographic data, measured parameters, predicted values, actual results, and percentage predicted.
  • Reports are evaluated to identify normal values and evaluate any deviations from the norm.
  • Key parameters for classification as normal are 80% or above for FVC and FEV1 and 70% or above for FEV1/FVC.

Alveolar-Arterial Oxygen Difference (A-a Gradient)

  • Calculated by subtracting arterial PO2 from alveolar PO2.
  • Normal value for healthy adults is less than 15 mmHg, typically rising with age.
  • A higher A-a gradient indicates problems in gas exchange.

Pulse Oximetry

  • Measures oxygen saturation (SaO2) in arterial blood using the pulsatile changes in cutaneous blood oxygen absorption.
  • Limitations include insensitivity to high PO2 levels, unreliable signals in low perfusion states, and inability to differentiate hemoglobin types.

Diffusing Capacity of the Lungs for Carbon Monoxide (DLCO)

  • Measures the rate of gas diffusion across the alveolar-capillary membrane.
  • Reduced DLCO is seen in conditions with decreased alveolar-capillary surface area or thickness of the membrane (e.g., interstitial lung diseases, emphysema).

Diseases Associated with Decreased DLCO

  • Various lung diseases, like asthma or COPD, can lead to a reduction in DLCO due to airway or lung tissue problems.

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Description

This quiz covers key techniques and measurements related to respiratory function. You'll explore spirometry, helium dilution methods, and understand various lung volumes and capacities essential for evaluating ventilatory function. Test your knowledge of ventilation, perfusion, and gas exchange processes.

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