Renal Tubules and Interstitium Disorders Quiz
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Questions and Answers

What is the most common cause of acute tubular injury?

  • Ischaemia (correct)
  • Viral infection
  • Bacterial infection
  • Fungal infection

Which factor contributes to reduced glomerular filtration rate in acute tubular injury?

  • Increased epithelial cell regeneration
  • Enhanced blood flow
  • Decreased inflammation
  • Detachment of injured cells from the basement membrane (correct)

What morphological changes are characteristic of tubular epithelial injury in acute tubular injury?

  • Increase in interstitial oedema
  • Decreased vacuolations in epithelial cells
  • Enhanced filtration membrane integrity
  • Formation of tubular casts (correct)

Which region of the nephron is most prominently affected by nephrotoxic acute tubular injury?

<p>Proximal convoluted tubules (C)</p> Signup and view all the answers

What term is used to describe the presence of vacuolations in tubular epithelial cells due to solute concentration?

<p>Osmotic stress nephropathy (A)</p> Signup and view all the answers

What is a characteristic feature seen in morphology indicating acute tubular injury?

<p><code>Presence of nuclei in necrotic tubular cells</code> (C)</p> Signup and view all the answers

What is the most common cause of acute kidney injury?

<p>Muddy brown granular cast (A)</p> Signup and view all the answers

Which condition involves inflammation of the interstitium surrounding the nephrons?

<p>Tubulointerstitial nephritis (B)</p> Signup and view all the answers

What is the preferred term for tubular damage that may not involve necrosis?

<p>Acute tubular injury (D)</p> Signup and view all the answers

How is tubulointerstitial nephritis diagnosed?

<p>Renal biopsy showing oedema and inflammatory infiltrate (C)</p> Signup and view all the answers

What is the primary treatment for tubulointerstitial nephritis?

<p>Removal of the causative agent (A)</p> Signup and view all the answers

Which cast type is commonly associated with acute tubular injury/necrosis?

<p>Epithelial cast (B)</p> Signup and view all the answers

What is the significance of the structure labelled 2 in the context provided?

<p>It leads to an abnormal ascent of the kidneys (A)</p> Signup and view all the answers

When would you consider performing renal angiography in a hypertensive patient?

<p>Increase in serum creatinine to 1.5 times baseline within 7 days (B)</p> Signup and view all the answers

Which scenario is classified as 'Failure' based on the RIFLE criteria for assessing renal injury severity?

<p>GFR reduced by 50% for 12 hours (D)</p> Signup and view all the answers

What are urinary casts as described in the text?

<p>Cylindrical structures produced by the kidney (B)</p> Signup and view all the answers

What could lead to an abnormal ascent of the kidneys?

<p>Inferior mesenteric artery positioning over the isthmus (A)</p> Signup and view all the answers

Which condition would not warrant consideration for renal angiography in hypertensive patients?

<p>Bruit sounds on renal auscultation (D)</p> Signup and view all the answers

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