Renal Tubular Epithelium Injury: Light Microscopy
35 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following is a characteristic of reversible injury due to ischemia in renal tubular epithelium?

  • Ruptured cytoplasmic membranes
  • Nuclear shrinkage and increased basophilia
  • Swelling and eosinophilia (correct)
  • Karyolysis

Which nuclear change is associated with irreversible injury (necrosis) in renal tubular epithelium?

  • Intact plasma membranes
  • Karyorrhexis (correct)
  • Both A and B
  • Distinct nuclear euchromatin and heterochromatin

In terms of reversible injury due to ischemia, what is a common feature observed in the cytoplasm of renal tubular epithelium?

  • Swelling and eosinophilia (correct)
  • Ruptured plasma membranes
  • Nuclear shrinkage
  • Karyolysis

What is the primary ultrastructural change observed in proximal tubular cells during reversible ischemic injury?

<p>Loss of microvilli (C)</p> Signup and view all the answers

Which of the following is a characteristic of irreversible ischemic injury in renal tubular epithelium?

<p>Swollen mitochondria with dense deposits (B)</p> Signup and view all the answers

What is the primary cause of reversible fatty change (steatosis) in the liver?

<p>A and C (D)</p> Signup and view all the answers

What is the characteristic histological feature of reversible hydropic change in the skin?

<p>Clear spaces within epidermal keratinocytes (A)</p> Signup and view all the answers

Steatosis is a medical condition characterized by the accumulation of sugar in the liver cells.

<p>False (B)</p> Signup and view all the answers

What is the primary source of the enzymes responsible for the digestion of necrotic cells?

<p>Both autolysis and heterolysis contribute (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic morphological change observed in necrotic cells?

<p>Rapid onset of changes within minutes of cell injury (C)</p> Signup and view all the answers

What is the purpose of the inflammatory reaction that often accompanies necrosis?

<p>To eliminate the dead cells and initiate the repair process (C)</p> Signup and view all the answers

Which of the following statements about myelin figures is correct?

<p>They are large, whorled phospholipid masses from damaged cell membranes (C)</p> Signup and view all the answers

What is the primary reason for the glassy, homogeneous appearance of necrotic cells?

<p>Loss of glycogen particles in the cytoplasm (C)</p> Signup and view all the answers

What is the primary mechanism behind the formation of chalky-white deposits in fat necrosis?

<p>The released fatty acids combine with calcium to produce the white deposits. (B)</p> Signup and view all the answers

Which of the following is the primary cause of fat necrosis in the context of acute pancreatitis?

<p>Leakage of activated pancreatic lipases into the peritoneal cavity. (A)</p> Signup and view all the answers

What is the microscopic appearance of necrotic fat cells in fat necrosis?

<p>Foci of shadowy, unclear outlines of necrotic fat cells with basophilic calcium deposits. (C)</p> Signup and view all the answers

What is the defining characteristic of the morphologic pattern of fibrinoid necrosis?

<p>The presence of a bright pink, amorphous appearance due to the deposition of fibrin and immune complexes. (D)</p> Signup and view all the answers

Which of the following is a common clinical condition associated with the development of fibrinoid necrosis?

<p>Malignant hypertension. (D)</p> Signup and view all the answers

Which of the following is a key feature of the morphologic pattern of wet gangrene?

<p>Liquefactive changes with a central yellow-green area. (A)</p> Signup and view all the answers

Which of the following nuclear changes is characterized by nuclear shrinkage and increased basophilia?

<p>Pyknosis (A)</p> Signup and view all the answers

What is the primary mechanism of coagulative necrosis?

<p>Denaturation of structural and enzymatic proteins leading to cell lysis (A)</p> Signup and view all the answers

Which morphologic pattern of necrosis is characterized by profound disruption leading to liquification of tissue?

<p>Liquefactive (B)</p> Signup and view all the answers

In which nuclear change does the pyknotic nucleus undergo fragmentation?

<p>Karyorrhexis (C)</p> Signup and view all the answers

What distinguishes karyolysis from pyknosis?

<p>Increased basophilia in karyolysis and basophilia fade in pyknosis (C)</p> Signup and view all the answers

Which morphologic pattern of necrosis is associated with a dry, black appearance due to ischemic coagulative necrosis?

<p>Gangrenous necrosis (A)</p> Signup and view all the answers

What is the term used to describe a wedge-shaped area of necrosis caused by an occluded artery in the kidney?

<p>Kidney infarct (C)</p> Signup and view all the answers

Which type of necrosis is characterized by the complete digestion of dead cells, transforming tissue into a gelatinous mass?

<p>Liquefactive necrosis (B)</p> Signup and view all the answers

Which of the following conditions is associated with caseous necrosis?

<p>Tuberculosis (A)</p> Signup and view all the answers

What is the characteristic histopathologic lesion observed in caseous necrosis?

<p>Granuloma with a central acellular necrosis (D)</p> Signup and view all the answers

Which organism is most likely to be detected by performing an acid-fast stain on a lesion exhibiting caseous necrosis?

<p><em>Mycobacterium tuberculosis</em> (D)</p> Signup and view all the answers

What is the term used to describe necrosis of a body part, typically a leg, that has undergone coagulation necrosis due to ischemia?

<p>Gangrenous necrosis (C)</p> Signup and view all the answers

What is the term used to describe gangrenous necrosis with superimposed infection, resulting in liquefactive necrosis?

<p>Wet gangrene (D)</p> Signup and view all the answers

Which of the following statements about coagulative necrosis is correct?

<p>It shows preserved cellular outlines with loss of nuclei (D)</p> Signup and view all the answers

Which type of necrosis is unique to the central nervous system, as opposed to other solid organs?

<p>Liquefactive necrosis (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of gangrenous necrosis?

<p>Caused by acute necrotizing infection with Clostridium perfringens (C)</p> Signup and view all the answers

More Like This

Use Quizgecko on...
Browser
Browser