Renal Physiology Quiz

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Questions and Answers

Na+ is pumped into the interstitial space by the Na+-K+ ATPase at the basolateral membrane.

True (A)

Passive transport does not play a role in tubular reabsorption of water and nutrients.

False (B)

Secondary active transport uses energy from ATP directly to transport substances.

False (B)

Aquaporins facilitate the passive transport of water in the renal tubules.

<p>True (A)</p> Signup and view all the answers

The paracellular route allows transport of substances between the cells, bypassing transport proteins.

<p>True (A)</p> Signup and view all the answers

Glucose is reabsorbed through paracellular transport exclusively.

<p>False (B)</p> Signup and view all the answers

Cotransport at the apical membrane involves the absorption of organic nutrients and certain ions.

<p>True (A)</p> Signup and view all the answers

Water is reabsorbed through channels called aquaporins.

<p>True (A)</p> Signup and view all the answers

Na+-K+ ATPase creates concentration gradients that drive the diffusion of certain nutrients.

<p>True (A)</p> Signup and view all the answers

Lipid-soluble substances are absorbed via the paracellular route.

<p>False (B)</p> Signup and view all the answers

Lipid-soluble substances pass through the membrane via primary active transport.

<p>False (B)</p> Signup and view all the answers

Na+ is transported into the interstitial space by the Na+-K+ ATPase at the apical membrane.

<p>False (B)</p> Signup and view all the answers

Ions such as Cl−, Ca2+, and K+ use the transcellular route for reabsorption.

<p>False (B)</p> Signup and view all the answers

Reabsorption of water increases the concentration of solutes that remain in the tubular fluid.

<p>True (A)</p> Signup and view all the answers

The reabsorption of organic nutrients occurs through cotransport at the basolateral membrane.

<p>False (B)</p> Signup and view all the answers

Primary active transport utilizes ion channels to absorb nutrients.

<p>False (B)</p> Signup and view all the answers

Passive transport mechanisms include the use of aquaporins for water movement.

<p>True (A)</p> Signup and view all the answers

Secondary active transport is essential for the absorption of certain nutrients and requires energy.

<p>True (A)</p> Signup and view all the answers

Tight junctions are responsible for the paracellular route of substance movement.

<p>True (A)</p> Signup and view all the answers

Water and nutrients reabsorption exclusively relies on active transport mechanisms.

<p>False (B)</p> Signup and view all the answers

Tight junctions are found in the paracellular route for reabsorption.

<p>True (A)</p> Signup and view all the answers

Concentration gradients created by active transport drive the entry of Na+ at the basolateral membrane.

<p>False (B)</p> Signup and view all the answers

Lipid-soluble substances can pass through membranes via diffusion.

<p>True (A)</p> Signup and view all the answers

Certain ions are reabsorbed through specific ion channels and passive transport.

<p>True (A)</p> Signup and view all the answers

The descending limb of the nephron is permeable to salt but not to water.

<p>False (B)</p> Signup and view all the answers

The ascending limb of the nephron impermeably pumps out salt.

<p>True (A)</p> Signup and view all the answers

Osmolality of filtrate decreases in the descending limb.

<p>False (B)</p> Signup and view all the answers

Water is reabsorbed in the ascending limb of the nephron.

<p>False (B)</p> Signup and view all the answers

The nephron's descending limb allows for the reabsorption of water.

<p>True (A)</p> Signup and view all the answers

The countercurrent mechanism increases the osmolality of the interstitial fluid by transporting NaCl out of the descending limb.

<p>False (B)</p> Signup and view all the answers

A constant difference of 200 mOsm exists between the two limbs of the nephron loop.

<p>True (A)</p> Signup and view all the answers

The osmotic gradient in the nephron loop ranges from 300 to 1200 mOsm.

<p>True (A)</p> Signup and view all the answers

Water diffuses out of the ascending limb, contributing to the formation of a salty filtrate.

<p>False (B)</p> Signup and view all the answers

The juxtamedullary nephrons feature short nephron loops that do not contribute to the osmotic gradient.

<p>False (B)</p> Signup and view all the answers

The countercurrent multiplier relies on positive feedback to enhance its effect on osmolality.

<p>True (A)</p> Signup and view all the answers

Filtrate flows in the same direction through both limbs of the nephron loop.

<p>False (B)</p> Signup and view all the answers

The process of countercurrent multiplication is essential for the kidney to produce concentrated urine.

<p>True (A)</p> Signup and view all the answers

Long nephron loops of juxtamedullary nephrons create the osmotic gradient in the renal medulla.

<p>True (A)</p> Signup and view all the answers

The countercurrent multiplier mechanism relies solely on active transport.

<p>False (B)</p> Signup and view all the answers

Water leaves the descending limb of the nephron loop into the interstitial fluid.

<p>True (A)</p> Signup and view all the answers

The flow of fluid in the nephron loop occurs in the same direction throughout.

<p>False (B)</p> Signup and view all the answers

The osmotic gradient established by the nephron loop is not important for kidney function.

<p>False (B)</p> Signup and view all the answers

Flashcards

Na+-K+ ATPase

A protein that pumps sodium out of the cell and potassium into the cell, using energy from ATP.

Active transport

The movement of molecules across a membrane against their concentration gradient, requiring energy.

Passive transport

Movement of molecules across a membrane down their concentration gradient, without energy input.

Concentration gradient

Difference in the concentration of a substance across a space.

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Tubular Reabsorption

The process of reclaiming water and solutes for recycling back into the bloodstream by the kidneys.

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Basolateral membrane

The membrane of a cell that faces away from the lumen (inside) of a tubule.

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Interstitial fluid

Fluid located in the spaces between cells.

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PCT

Proximal convoluted tubule, parts of the nephron involved in reabsorption and secretion.

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Primary Active Transport

Movement of a substance across a cell membrane against its concentration gradient using ATP.

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Secondary Active Transport

Movement of one substance against its concentration gradient using the energy from another substance moving down its concentration gradient.

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Filtrate

Fluid that has passed through the filtration membrane of the kidney.

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Apical Membrane

The cell membrane facing the lumen (inside) of the nephron.

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Organic Nutrient Reabsorption

The reabsorption of nutrients like glucose and amino acids, often coupled with sodium.

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Paracellular Route

Substances pass between cells in the epithelium.

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Transcellular Route

Substances move through cells in the epithelium.

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Ion Channels

Specialized proteins that allow specific ions to move across the membrane based on their electrochemical gradient.

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Aquaporins

Channel proteins specific for water transport

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Lipid Soluble Substances

Substances that can freely pass through the cell membrane.

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Descending Limb Permeability

The descending limb of the loop of Henle is freely permeable to water but impermeable to salt. This allows water to move out of the filtrate and into the surrounding interstitial fluid, concentrating the filtrate.

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Ascending Limb Permeability

The ascending limb of the loop of Henle is impermeable to water but actively pumps salt out of the filtrate. This dilutes the filtrate and helps create the concentration gradient in the medulla.

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Filtrate Concentration in Descending Limb

As water moves out of the filtrate in the descending limb, the concentration of the filtrate increases. This is due to the osmotic gradient created by the high concentration of salt in the interstitial fluid.

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Filtrate Dilution in Ascending Limb

As salt is actively pumped out of the filtrate in the ascending limb, the concentration of the filtrate decreases. This helps maintain the concentration gradient in the medulla, necessary for water reabsorption.

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Loop of Henle Function

The loop of Henle plays a critical role in concentrating urine by creating a concentration gradient in the medulla using the countercurrent multiplier system. This gradient ensures that the kidneys can conserve water efficiently.

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Countercurrent Multiplier

A mechanism that uses the flow of fluid in opposite directions through two parallel sections of a nephron loop to create an osmotic gradient in the renal medulla.

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Descending Limb

The section of the nephron loop that is permeable to water, allowing water to move out into the interstitial fluid.

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Ascending Limb

The section of the nephron loop that is impermeable to water, but actively transports salt out into the interstitial fluid.

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Positive Feedback Cycle

A process where the output of a system amplifies the input, leading to a self-reinforcing effect.

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Osmotic Gradient

A difference in solute concentration across a membrane, causing water to move from areas of high concentration to areas of low concentration.

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Medullary Interstitial Fluid

The fluid surrounding the nephron loops in the renal medulla, with a high concentration of solutes.

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Juxtamedullary Nephrons

Nephrons with long nephron loops that extend deep into the renal medulla, responsible for creating the osmotic gradient.

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Study Notes

Renal Tubular Reabsorption

  • Na+-K+ ATPase pumps sodium ions (Na+) into the interstitial space from the basolateral membrane, creating a concentration gradient that drives the diffusion of other nutrients.
  • Secondary active transport utilizes energy from ATP indirectly (through concentration gradients) to transport substances, playing a key role in absorbing organic compounds.
  • Passive transport contributes to the process through the movement of water by aquaporins and certain ions using ion channels.
  • Paracellular route allows substances to move between cells, bypassing transport proteins. It is important for reabsorption of certain ions, like chloride (Cl−), calcium (Ca2+), and potassium (K+).
  • Cotransport at the apical membrane involves the absorption of organic nutrients like glucose alongside sodium ions.
  • Tight junctions are crucial for the paracellular route by regulating the passage of substances.
  • Lipid-soluble substances can directly diffuse across cell membranes.
  • Reabsorption of water increases the concentration of solutes remaining in the tubular fluid.

Countercurrent Mechanism in the Nephron Loop

  • Descending limb of the nephron loop is permeable to water, but not salt, allowing for reabsorption of water into the interstitial fluid.
  • Ascending limb of the nephron loop is impermeably to water but actively pumps out salt, resulting in an increase in the osmolality of the interstitial fluid.
  • Countercurrent multiplier relies on the positive feedback mechanism of transporting NaCl out of the ascending limb, contributing to the increasing osmolality in the interstitial fluid.
  • Osmotic gradient established by the nephron loop ranges from 300 to 1200 mOsm, facilitating a constant difference of 200 mOsm between the two limbs.
  • Long nephron loops in juxtamedullary nephrons are essential for creating and maintaining the osmotic gradient in the renal medulla.
  • Filtrate flows in opposite directions through the two limbs of the nephron loop – descending limb receives filtrate from the proximal convoluted tubule, moving down towards the loop of Henle, while the ascending limb moves filtrate towards the distal convoluted tubule.
  • Countercurrent multiplication is the mechanism essential for the kidney to produce concentrated urine.

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