17 Questions
What is the main function of the size selective barrier of the GBM in glomerular filtration?
To repel negatively charged blood proteins
What is the primary cause of oedema in nephrotic syndrome?
Hypoalbuminemia
What is the most common cause of primary nephrotic syndrome?
Minimal change disease
What is the reason for elevated serum lipid levels in nephrotic syndrome?
Hypoalbuminemia stimulating lipoprotein synthesis
What is the primary function of the glomerular capillary walls?
To filter plasma
Which of the following is NOT a component of the glomerular basement membrane?
Fenestrations
What is a common complication of nephrotic syndrome?
Increased risk of infections
What is the effect of nephrotic syndrome on glomerular capillary wall permeability?
Increased permeability
What is the molecular weight of proteins that are NOT found in the ultrafiltrate?
≥68 kd
Which structure is responsible for allowing the glomerular filtrate to pass through?
Endothelial fenestrae
What is the term for the resulting fluid after plasma has been filtered through the glomerular capillary walls?
Ultrafiltrate
What is the purpose of the epithelial cell foot processes?
To form the filtration slits
What is a cause of the hypercoagulable state in nephrotic syndrome?
Decreased fibrinolytic factors
What is the most common age range for the idiopathic nephrotic syndrome to appear?
Between 2 and 6 years
What is a complication of the nephrotic syndrome?
Thromboembolic events
What percentage of patients have MCNS?
85-90%
What is a cause of the loss of opsonins in the urine?
Loss of complement factor C3b
This quiz assesses the learning outcomes of MBBS 3 students on renal diseases, including pathogenesis and management of nephrotic syndrome and post infectious glomerulonephritis, as well as complications and electron micrograph of normal glomerular capillary.
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