Podcast
Questions and Answers
What is the role of histone acetylation by histone acetyltransferases (HATs) in chromatin structure?
What is the role of histone acetylation by histone acetyltransferases (HATs) in chromatin structure?
Which mechanism causes chromatin to become tightly closed?
Which mechanism causes chromatin to become tightly closed?
What effect does methylation have on chromatin structure?
What effect does methylation have on chromatin structure?
Which process results in shifts of nucleosomes along the DNA?
Which process results in shifts of nucleosomes along the DNA?
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What is the role of specialized histone variants in chromatin structure?
What is the role of specialized histone variants in chromatin structure?
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What is the main effect of acetylation by histone acetyltransferases (HATs) on chromatin structure?
What is the main effect of acetylation by histone acetyltransferases (HATs) on chromatin structure?
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Which process is responsible for homologous proteins with extensions having different functions being substituted into chromatin?
Which process is responsible for homologous proteins with extensions having different functions being substituted into chromatin?
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What effect does methylation have on chromatin structure?
What effect does methylation have on chromatin structure?
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Which mechanism involves ATP-dependent changes that result in shifting nucleosomes along the DNA?
Which mechanism involves ATP-dependent changes that result in shifting nucleosomes along the DNA?
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Study Notes
Regulation of Chromatin Structure
- Chromatin structure is controlled and changed by at least three mechanisms:
ATP-dependent changes in nucleosome positioning
- Involve shifts of nucleosomes along the DNA
Posttranslational chemical modifications of histone proteins
- Acetylation by histone acetyltransferases (HATs) leads to decondensing of chromatin
- Methylation causes chromatin to become tightly closed
Substitution of specialized histone variants into chromatin
- Proteins are homologous to the common histones, but with extensions that have different functions
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Description
Test your knowledge on the mechanisms involved in controlling and changing chromatin structure, including ATP-dependent changes, posttranslational modifications of histone proteins, and substitution of specialized histone variants. Explore how nucleosome positioning, histone acetylation, methylation, and histone variant substitution impact chromatin structure.
