Podcast
Questions and Answers
Who are the researchers involved in the study?
Who are the researchers involved in the study?
Motoko Naitoh, Kazutoshi Takahashi, Takuya Yamamoto, Fumihiko Adachi, Takayuki Kondo, Keisuke Okita, Isao Asaka, Takashi Aoi, Akira Watanabe, Yasuhiro Yamada, Asuka Morizane, Jun Takahashi, Takashi Ayaki, Hidefumi Ito, Katsuhiro Yoshikawa, Satoko Yamawaki, Shigehiko Suzuki, Dai Watanabe, Hiroyuki Hioki, Takeshi Kaneko, Kouki Makioka, Koichi Okamoto, Hiroshi Takuma, Akira Tamaoka, Kazuko Hasegawa, Takashi Nonaka, Masato Hasegawa, Akihiro Kawata, Minoru Yoshida, Tatsutoshi Nakahata, Ryosuke Takahashi, Maria C. N. Marchetto, Fred H. Gage, Shinya Yamanaka, and Haruhisa Inoue.
What did the iPSC-derived motor neurons exhibit?
What did the iPSC-derived motor neurons exhibit?
Cytosolic aggregates similar to those seen in postmortem tissue from ALS patients and exhibited shorter neurites as seen in a zebrafish model of ALS.
What are the key findings of the study?
What are the key findings of the study?
iPSC-derived motor neurons formed cytosolic aggregates similar to those seen in postmortem tissue from ALS patients and exhibited shorter neurites as seen in a zebrafish model of ALS.
What is the significance of the observed cytosolic aggregates in iPSC-derived motor neurons?
What is the significance of the observed cytosolic aggregates in iPSC-derived motor neurons?
Which researchers are affiliated with more than one institution?
Which researchers are affiliated with more than one institution?
Flashcards
iPSC-derived motor neurons
iPSC-derived motor neurons
Motor neurons created from induced pluripotent stem cells.
ALS patient aggregates
ALS patient aggregates
Abnormal clumps seen within ALS patient cells (post-mortem)
Cytosolic aggregates in iPSC neurons
Cytosolic aggregates in iPSC neurons
Similar clumps found in the iPSC-derived motor neuron cells, matching the ALS pattern
Short neurites
Short neurites
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Study implication
Study implication
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