5 Questions
Who are the researchers involved in the study?
Motoko Naitoh, Kazutoshi Takahashi, Takuya Yamamoto, Fumihiko Adachi, Takayuki Kondo, Keisuke Okita, Isao Asaka, Takashi Aoi, Akira Watanabe, Yasuhiro Yamada, Asuka Morizane, Jun Takahashi, Takashi Ayaki, Hidefumi Ito, Katsuhiro Yoshikawa, Satoko Yamawaki, Shigehiko Suzuki, Dai Watanabe, Hiroyuki Hioki, Takeshi Kaneko, Kouki Makioka, Koichi Okamoto, Hiroshi Takuma, Akira Tamaoka, Kazuko Hasegawa, Takashi Nonaka, Masato Hasegawa, Akihiro Kawata, Minoru Yoshida, Tatsutoshi Nakahata, Ryosuke Takahashi, Maria C. N. Marchetto, Fred H. Gage, Shinya Yamanaka, and Haruhisa Inoue.
What did the iPSC-derived motor neurons exhibit?
Cytosolic aggregates similar to those seen in postmortem tissue from ALS patients and exhibited shorter neurites as seen in a zebrafish model of ALS.
What are the key findings of the study?
iPSC-derived motor neurons formed cytosolic aggregates similar to those seen in postmortem tissue from ALS patients and exhibited shorter neurites as seen in a zebrafish model of ALS.
What is the significance of the observed cytosolic aggregates in iPSC-derived motor neurons?
They are similar to those seen in postmortem tissue from ALS patients, indicating a potential disease relevance.
Which researchers are affiliated with more than one institution?
Takuya Yamamoto, Fumihiko Adachi, Akira Watanabe, Yasuhiro Yamada, Jun Takahashi, and Shinya Yamanaka.
Test your knowledge of regenerative medicine, specifically cell-based therapies from pluripotent stem cells. Explore the main goals of employing stem cells in transplantation therapies and improving the regenerative potential of adult stem cells and tissues.
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