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Questions and Answers
If 5000 capsules of the triple estrogen formula are to be manufactured, how many grams of mineral oil are needed?
If 5000 capsules of the triple estrogen formula are to be manufactured, how many grams of mineral oil are needed?
A formula for an ophthalmic solution requires 500 mg of erythromycin lactobionate for every 100 mL. How much erythromycin lactobionate is needed for 15 mL of this solution?
A formula for an ophthalmic solution requires 500 mg of erythromycin lactobionate for every 100 mL. How much erythromycin lactobionate is needed for 15 mL of this solution?
How many milligrams of alefacept are in 0.6 mL of the reconstituted AMEVIVE product?
How many milligrams of alefacept are in 0.6 mL of the reconstituted AMEVIVE product?
What would be the combined total weight, in grams, of the polyethylene glycols (1450 and 3350) in the triple estrogen formula?
What would be the combined total weight, in grams, of the polyethylene glycols (1450 and 3350) in the triple estrogen formula?
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If a batch of the triple estrogen capsules requires 1 kg of polyethylene glycol 3350, how many capsules are being manufactured?
If a batch of the triple estrogen capsules requires 1 kg of polyethylene glycol 3350, how many capsules are being manufactured?
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What is the total weight of the polyethylene glycols in formulation 9?
What is the total weight of the polyethylene glycols in formulation 9?
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Which formulation includes the ingredient ergotamine tartrate?
Which formulation includes the ingredient ergotamine tartrate?
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What is the total amount of sodium bicarbonate in formulations 16 and 7 combined?
What is the total amount of sodium bicarbonate in formulations 16 and 7 combined?
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Which formulation includes the ingredient alefacept?
Which formulation includes the ingredient alefacept?
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What is the total mass of the three different estrogens in formulation 9?
What is the total mass of the three different estrogens in formulation 9?
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Which of the following ingredients is present in formulation 18?
Which of the following ingredients is present in formulation 18?
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Which formulation contains sorbitol?
Which formulation contains sorbitol?
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What is the total amount in mEq of chloride in formulation 19?
What is the total amount in mEq of chloride in formulation 19?
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If a formula for calamine lotion requires 80 g of calamine and you need to make 240 mL of lotion, how much calamine is needed?
If a formula for calamine lotion requires 80 g of calamine and you need to make 240 mL of lotion, how much calamine is needed?
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A calamine lotion formula calls for 20 mL of glycerin in a 1000 mL batch. How much glycerin is required to make 240 mL of the lotion?
A calamine lotion formula calls for 20 mL of glycerin in a 1000 mL batch. How much glycerin is required to make 240 mL of the lotion?
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In a formula for calamine lotion, if 250 mL of bentonite magma is required for a 1000 mL batch, how much is needed for a 240 mL batch?
In a formula for calamine lotion, if 250 mL of bentonite magma is required for a 1000 mL batch, how much is needed for a 240 mL batch?
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If a formula needs 80 g of zinc oxide for 1000 mL of solution, how much zinc oxide is needed for 240 mL?
If a formula needs 80 g of zinc oxide for 1000 mL of solution, how much zinc oxide is needed for 240 mL?
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In the polyvinyl alcohol formula, what is the total volume of the sterile sodium chloride solution after applying the factor of 3.6?
In the polyvinyl alcohol formula, what is the total volume of the sterile sodium chloride solution after applying the factor of 3.6?
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If you need to scale up the polyvinyl alcohol formula by a factor of 2.5, what quantity of chlorobutanol is required?
If you need to scale up the polyvinyl alcohol formula by a factor of 2.5, what quantity of chlorobutanol is required?
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A formula calls for 250 mL of ingredient 'X' to make 1000 mL product. What factor should be used to calculate the amount of ingredient 'X' if you need to make 240 mL of the product?
A formula calls for 250 mL of ingredient 'X' to make 1000 mL product. What factor should be used to calculate the amount of ingredient 'X' if you need to make 240 mL of the product?
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In the calamine lotion example, what is the total volume of the solution that the original formula makes?
In the calamine lotion example, what is the total volume of the solution that the original formula makes?
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In the estradiol vaginal gel formula, what was the total weight of all ingredients before applying the scaling factor?
In the estradiol vaginal gel formula, what was the total weight of all ingredients before applying the scaling factor?
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If a formula for a product needed 500 mL of a base and you wanted to produce 100 mL, what factor would you use?
If a formula for a product needed 500 mL of a base and you wanted to produce 100 mL, what factor would you use?
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For the estradiol vaginal gel formula, what is the scaling factor used to determine the amount of ingredients needed for 1 lb (454 g)?
For the estradiol vaginal gel formula, what is the scaling factor used to determine the amount of ingredients needed for 1 lb (454 g)?
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If you were to scale the estradiol vaginal gel to a total weight of 900 g, what would be the required amount of polysorbate 80, assuming the original ratio of ingredients is maintained?
If you were to scale the estradiol vaginal gel to a total weight of 900 g, what would be the required amount of polysorbate 80, assuming the original ratio of ingredients is maintained?
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What is the purpose of the multiplying factor when scaling a formula?
What is the purpose of the multiplying factor when scaling a formula?
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How many grams of estradiol are needed to prepare 1 lb of estradiol vaginal gel?
How many grams of estradiol are needed to prepare 1 lb of estradiol vaginal gel?
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In the polyvinyl alcohol formula, what is the combined weight of polyvinyl alcohol, povidone, and chlorobutanol after applying the scaling factor of 3.6?
In the polyvinyl alcohol formula, what is the combined weight of polyvinyl alcohol, povidone, and chlorobutanol after applying the scaling factor of 3.6?
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If you need to prepare 2 lb of the estradiol vagainal gel, what amount of methylcellulose gel will you require?
If you need to prepare 2 lb of the estradiol vagainal gel, what amount of methylcellulose gel will you require?
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A formula for a topical solution specifies 25 g of active ingredient per 500 mL. If a pharmacist wants to prepare only 200 mL of this solution, how many grams of active ingredient are needed?
A formula for a topical solution specifies 25 g of active ingredient per 500 mL. If a pharmacist wants to prepare only 200 mL of this solution, how many grams of active ingredient are needed?
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A manufacturing process uses a formula with 1500mg of preservative per 100mL. If the batch size is to be 250mL, how much preservative is required?
A manufacturing process uses a formula with 1500mg of preservative per 100mL. If the batch size is to be 250mL, how much preservative is required?
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A formula for a cream contains 12 g of cetyl alcohol in 60 grams of cream. What weight of cetyl alcohol is required for a total preparation of 90 grams of the same cream?
A formula for a cream contains 12 g of cetyl alcohol in 60 grams of cream. What weight of cetyl alcohol is required for a total preparation of 90 grams of the same cream?
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A formula calls for 500mg of a drug for 10 capsules. If a pharmacist needs to prepare 25 capsules, how many milligrams of the drug are needed?
A formula calls for 500mg of a drug for 10 capsules. If a pharmacist needs to prepare 25 capsules, how many milligrams of the drug are needed?
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A formula specifies 15 mL of glycerin in 250 mL of solution. If a pharmacist is preparing 60 mL of the same solution how much glycerin should be used?
A formula specifies 15 mL of glycerin in 250 mL of solution. If a pharmacist is preparing 60 mL of the same solution how much glycerin should be used?
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An industrial formula for a lotion contains 20kg of cetrimide in 100kg of lotion. If a pharmacist requires 15kg of the same lotion, how many kilograms of cetrimide are required?
An industrial formula for a lotion contains 20kg of cetrimide in 100kg of lotion. If a pharmacist requires 15kg of the same lotion, how many kilograms of cetrimide are required?
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A topical ointment requires 5g of menthol per 200g of ointment. How many grams of menthol are needed to make 75g of the same ointment?
A topical ointment requires 5g of menthol per 200g of ointment. How many grams of menthol are needed to make 75g of the same ointment?
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A formula for an oral suspension contains 100 mg of an active ingredient per 5 mL. If a pharmacist needs to prepare 120 mL of the suspension, how many milligrams of active ingredient are required?
A formula for an oral suspension contains 100 mg of an active ingredient per 5 mL. If a pharmacist needs to prepare 120 mL of the suspension, how many milligrams of active ingredient are required?
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Using the first formula provided, how many grams of tetracaine hydrochloride are present in a 30g batch?
Using the first formula provided, how many grams of tetracaine hydrochloride are present in a 30g batch?
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In the sports rub cream formula, if you need to prepare 240 grams of cream, how much menthol do you need?
In the sports rub cream formula, if you need to prepare 240 grams of cream, how much menthol do you need?
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For the electrolyte solution, how much sodium chloride is required to make 8 Liters of solution?
For the electrolyte solution, how much sodium chloride is required to make 8 Liters of solution?
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In the suppository formula for migraine headaches, how much pentobarbital sodium is needed to prepare 250 suppositories?
In the suppository formula for migraine headaches, how much pentobarbital sodium is needed to prepare 250 suppositories?
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If you were to make 60 of the rectal suppositories, as per the second formula given, what quantity of polyethylene glycol 1000 would be needed in total?
If you were to make 60 of the rectal suppositories, as per the second formula given, what quantity of polyethylene glycol 1000 would be needed in total?
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Using the sports rub cream formula, and given that the specific gravity of methyl salicylate is 1.18, how many grams of methyl salicylate are needed to prepare 300 g of cream?
Using the sports rub cream formula, and given that the specific gravity of methyl salicylate is 1.18, how many grams of methyl salicylate are needed to prepare 300 g of cream?
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In the electrolyte solution formula, what is the total mass of all the solid ingredients needed to make 2 liters of the solution?
In the electrolyte solution formula, what is the total mass of all the solid ingredients needed to make 2 liters of the solution?
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If you need to make 50 of the migraine headache suppositories, how much Hyoscyamine Sulfate is needed?
If you need to make 50 of the migraine headache suppositories, how much Hyoscyamine Sulfate is needed?
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Study Notes
Reducing and Enlarging Formulas
- Pharmaceutical formulas often require adjustments in quantity for various reasons, like preparing smaller or larger batches.
- Formulas are frequently based on 1000 mL or 1000 g, but other quantities are also used.
- Calculations involve determining a factor to adjust quantities proportionally.
- The factor is determined by dividing the desired quantity by the given quantity. Factors greater than one represent a multiplication, and less than one represent a reduction.
- To adjust the formula, multiply the quantity of each ingredient by the calculated factor.
Objectives
- Students should be able to perform calculations adjusting formulas in metric units.
- Students should be able to calculate adjustments to formulas based on proportional parts.
Example Calculations
- Calculations can be used to adjust the quantities of ingredients in a formula to create a specific amount of product.
- The factor used to determine quantities for reducing or enlarging a formula is calculated by dividing the desired amount by the given amount.
- This method works for both scaling up or scaling down a given formula.
Formula Parts
- Formulas may be described in proportional parts (e.g., 5 parts, 10 parts) rather than specific weight.
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Description
This quiz focuses on the techniques of adjusting pharmaceutical formulas for varying batch sizes. Students will learn how to calculate factors for modifications based on proportional parts and metric units. Example calculations will guide learners through practical applications of these adjustments.
