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Questions and Answers
Which type of inheritance pattern is associated with sickle cell disease?
Which type of inheritance pattern is associated with sickle cell disease?
- Autosomal recessive (correct)
- X-linked dominant
- Y-linked
- Autosomal dominant
What is the composition of sickle haemoglobin (HbS)?
What is the composition of sickle haemoglobin (HbS)?
- Alpha-2 α chains
- Alpha-2 β (sickle) chains (correct)
- Beta Point mutation
- Gamma Delta BetaS
Which term describes individuals who are carriers of sickle cell disease but are asymptomatic?
Which term describes individuals who are carriers of sickle cell disease but are asymptomatic?
- HbAS (correct)
- HbSS
- HbAA
- HbAS (correct)
What triggers the pathophysiology of sickle cell disease?
What triggers the pathophysiology of sickle cell disease?
What is the chance of having an affected child if both parents are carriers of sickle cell disease?
What is the chance of having an affected child if both parents are carriers of sickle cell disease?
Which condition is characterized by a reduced or absent production of globin chains?
Which condition is characterized by a reduced or absent production of globin chains?
What is the main consequence of homozygous alpha zero thalassaemia (α0/α0)?
What is the main consequence of homozygous alpha zero thalassaemia (α0/α0)?
Which of the following events can trigger a sickle crisis in sickle cell disease?
Which of the following events can trigger a sickle crisis in sickle cell disease?
Which type of anaemia is present in beta thalassaemia major?
Which type of anaemia is present in beta thalassaemia major?
What is the primary management strategy for G6PD deficiency?
What is the primary management strategy for G6PD deficiency?
In which condition should hydration, oxygenation, and prompt treatment of infection be part of the management?
In which condition should hydration, oxygenation, and prompt treatment of infection be part of the management?
What is the most common disease causing enzymopathy in the world?
What is the most common disease causing enzymopathy in the world?
Which enzyme deficiency leads to increased rigidity of red blood cells and variable severity of symptoms?
Which enzyme deficiency leads to increased rigidity of red blood cells and variable severity of symptoms?
What triggers hemolysis in G6PD Deficiency?
What triggers hemolysis in G6PD Deficiency?
In which part of the body is Erythropoietin synthesized in response to hypoxia?
In which part of the body is Erythropoietin synthesized in response to hypoxia?
Which type of hemoglobin has a higher oxygen affinity than HbA?
Which type of hemoglobin has a higher oxygen affinity than HbA?
What is the normal percentage of Hemoglobin F found in adults?
What is the normal percentage of Hemoglobin F found in adults?
Which condition results from mutations leading to structurally abnormal globin chains?
Which condition results from mutations leading to structurally abnormal globin chains?
What happens in G6PD Deficiency when triggered by oxidative stress?
What happens in G6PD Deficiency when triggered by oxidative stress?
Which drug can trigger hemolysis in individuals with G6PD Deficiency?
Which drug can trigger hemolysis in individuals with G6PD Deficiency?
What role does Hemoglobin play in gas exchange within the body?
What role does Hemoglobin play in gas exchange within the body?
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