Y1S1 003 III Physiology Red Blood Cell
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Questions and Answers

In which condition are leptocytes typically seen?

  • Cancer that has spread to the bone marrow
  • Conditions causing excessive production of hemoglobin
  • Erythroblastosis fetalis
  • Thalassemias (correct)

    • What percentage of glucose is metabolized by the pentose phosphate pathway in red blood cells?

  • 30%
  • 10% (correct)
  • 5%
  • 20%

    • What is the function of the MCHC test?

  • Measuring the average amount of hemoglobin in each red blood cell
  • Calculating the concentration of hemoglobin in a single red blood cell (correct)
  • Describing the size of red blood cells
  • Determining the ratio of red blood cells to total blood volume

    • What is the primary function of the hexose monophosphate shunt in red blood cells?

    <p>To provide reducing power to protect RBCs from oxidative stress</p> Signup and view all the answers

    What is the name of the parameter that measures the ratio of red blood cells to total blood volume?

    <p>Haematocrit</p> Signup and view all the answers

    What is the net gain of ATP for every mole of glucose metabolized in red blood cells?

    <p>2 moles of ATP</p> Signup and view all the answers

    In which condition may normoblasts be seen?

    <p>All of the above</p> Signup and view all the answers

    What is the name of the parameter that measures the average amount of hemoglobin in each red blood cell?

    <p>Mean Corpuscular Haemoglobin</p> Signup and view all the answers

    What is the role of G6PD in red blood cells?

    <p>To protect cells from oxidant stress</p> Signup and view all the answers

    What is the most common triggers of hemolysis in G6PD deficiency?

    <p>Antimalarials and analgesics</p> Signup and view all the answers

    What is the method used to determine Haematocrit?

    <p>Centrifugation</p> Signup and view all the answers

    What is the primary site of action of 2,3-DPG in red blood cells?

    <p>Hemoglobin molecule</p> Signup and view all the answers

    What is the primary function of erythrocytes in the human body?

    <p>To transport oxygen from the lungs to the tissues and carbon dioxide from the tissues to the lungs</p> Signup and view all the answers

    What is the characteristic shape of mature erythrocytes?

    <p>Biconcave disc</p> Signup and view all the answers

    Which organelles are absent in mature erythrocytes?

    <p>Ribosomes, mitochondria, and other organelles typical of most body cells</p> Signup and view all the answers

    What is the approximate number of hemoglobin molecules in a mature erythrocyte?

    <p>200,000 to 300,000</p> Signup and view all the answers

    What is the primary mechanism of metabolism in immature erythrocytes?

    <p>Tricarboxylic Acid (TCA) cycle and electron transfer chain</p> Signup and view all the answers

    What is the fate of pyruvate in mature erythrocytes?

    <p>It is converted to lactate</p> Signup and view all the answers

    What is the primary source of iron for daily hemoglobin synthesis?

    <p>Breakdown of senescent RBCs</p> Signup and view all the answers

    What is the effect of haeme accumulation on protoporphyrin synthesis?

    <p>It decreases protoporphyrin synthesis through feedback inhibition</p> Signup and view all the answers

    What is the approximate percentage of HbF in adult hemoglobin?

    <p>0.5-0.8%</p> Signup and view all the answers

    What is the function of heme in hemoglobin?

    <p>To transport oxygen</p> Signup and view all the answers

    What is the characteristic of carboxyhemoglobin?

    <p>It has a 218 times greater affinity to CO than O2</p> Signup and view all the answers

    What is the primary characteristic of hemoglobinopathies?

    <p>Abnormalities in globin production</p> Signup and view all the answers

    What is the normal range of Packed Cell Volume (PCV) or Hematocrit in females?

    <p>36 - 46%</p> Signup and view all the answers

    What is the process by which blood cells enter the circulation?

    <p>Diapedesis</p> Signup and view all the answers

    What is the primary purpose of a platelet count test?

    <p>Diagnosing bleeding disorders</p> Signup and view all the answers

    What is the minimum percentage of reticulocyte count required to indicate increased erythropoietic activity?

    <p>2.5%</p> Signup and view all the answers

    What is the compound that binds with an atom of iron to form haeme?

    <p>Protoporphyrin</p> Signup and view all the answers

    What is the only component that a developing normoblast lacks to make haemoglobin?

    <p>Iron</p> Signup and view all the answers

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