Rectal Dosage Forms for Local and Systemic Action

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Questions and Answers

What is the main purpose of rectal dosage forms intended for local effect?

  • Improving taste perception
  • Treating systemic conditions
  • Managing haemorrhoids (correct)
  • Combating viral infections

Which type of drugs are commonly included in rectal dosage forms for local effect?

  • Antibiotics and antifungals
  • Antihypertensives and anticoagulants
  • Astringents and local anaesthetics (correct)
  • Corticosteroids and bronchodilators

What is the most commonly used type of rectal dosage form?

  • Enemas
  • Rectal foams
  • Capsules
  • Suppositories (correct)

How are rectal suppositories described in terms of their preparation?

<p>Single-dose preparations (B)</p> Signup and view all the answers

Which type of bases are commonly used in formulating rectal suppositories for hydrophilic drugs?

<p>Water-soluble bases (D)</p> Signup and view all the answers

What is a key characteristic of the ideal suppository base?

<p>High thermodynamic tendency for drug retention (A)</p> Signup and view all the answers

What is the main reason for the lower rate and extent of drug absorption in the rectum compared to the oral route?

<p>Smaller surface area for absorption (D)</p> Signup and view all the answers

Why is rectal drug delivery considered a safe route of drug administration?

<p>Reduces first-pass metabolism (A)</p> Signup and view all the answers

Why is the rectal route suitable for drugs that are liable to degrade in the gastrointestinal tract (GIT)?

<p>Avoids hepatic first-pass elimination (D)</p> Signup and view all the answers

Which patient group finds rectal dosage forms less acceptable for long-term therapy?

<p>Elderly patients (A)</p> Signup and view all the answers

In rectal drug delivery, what factor can lead to an increase in first-pass metabolism if incorrectly positioned?

<p>Presence of contents in the rectum (D)</p> Signup and view all the answers

Why is rectal drug delivery suitable for pediatric patients?

<p>Avoids hepatic first-pass elimination (D)</p> Signup and view all the answers

Which of the following statements about rectal drug delivery is correct?

<p>The temperature within the rectum is approximately 37°C. (C)</p> Signup and view all the answers

Which of the following conditions is most suitable for rectal drug delivery?

<p>Hemorrhoids (C)</p> Signup and view all the answers

What is the primary mechanism of drug absorption following rectal administration?

<p>Passive diffusion (D)</p> Signup and view all the answers

Which of the following statements is true regarding the pH of rectal fluids?

<p>The pH is approximately 7.2-7.5 in adults and 7.2-12.1 in children. (C)</p> Signup and view all the answers

Which of the following dosage forms is most suitable for rectal drug delivery?

<p>Suppositories (A)</p> Signup and view all the answers

What is the primary advantage of rectal drug delivery over oral administration?

<p>Avoidance of first-pass metabolism (B)</p> Signup and view all the answers

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