Rectal Dosage Forms for Local and Systemic Action
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Questions and Answers

What is the main purpose of rectal dosage forms intended for local effect?

  • Improving taste perception
  • Treating systemic conditions
  • Managing haemorrhoids (correct)
  • Combating viral infections
  • Which type of drugs are commonly included in rectal dosage forms for local effect?

  • Antibiotics and antifungals
  • Antihypertensives and anticoagulants
  • Astringents and local anaesthetics (correct)
  • Corticosteroids and bronchodilators
  • What is the most commonly used type of rectal dosage form?

  • Enemas
  • Rectal foams
  • Capsules
  • Suppositories (correct)
  • How are rectal suppositories described in terms of their preparation?

    <p>Single-dose preparations</p> Signup and view all the answers

    Which type of bases are commonly used in formulating rectal suppositories for hydrophilic drugs?

    <p>Water-soluble bases</p> Signup and view all the answers

    What is a key characteristic of the ideal suppository base?

    <p>High thermodynamic tendency for drug retention</p> Signup and view all the answers

    What is the main reason for the lower rate and extent of drug absorption in the rectum compared to the oral route?

    <p>Smaller surface area for absorption</p> Signup and view all the answers

    Why is rectal drug delivery considered a safe route of drug administration?

    <p>Reduces first-pass metabolism</p> Signup and view all the answers

    Why is the rectal route suitable for drugs that are liable to degrade in the gastrointestinal tract (GIT)?

    <p>Avoids hepatic first-pass elimination</p> Signup and view all the answers

    Which patient group finds rectal dosage forms less acceptable for long-term therapy?

    <p>Elderly patients</p> Signup and view all the answers

    In rectal drug delivery, what factor can lead to an increase in first-pass metabolism if incorrectly positioned?

    <p>Presence of contents in the rectum</p> Signup and view all the answers

    Why is rectal drug delivery suitable for pediatric patients?

    <p>Avoids hepatic first-pass elimination</p> Signup and view all the answers

    Which of the following statements about rectal drug delivery is correct?

    <p>The temperature within the rectum is approximately 37°C.</p> Signup and view all the answers

    Which of the following conditions is most suitable for rectal drug delivery?

    <p>Hemorrhoids</p> Signup and view all the answers

    What is the primary mechanism of drug absorption following rectal administration?

    <p>Passive diffusion</p> Signup and view all the answers

    Which of the following statements is true regarding the pH of rectal fluids?

    <p>The pH is approximately 7.2-7.5 in adults and 7.2-12.1 in children.</p> Signup and view all the answers

    Which of the following dosage forms is most suitable for rectal drug delivery?

    <p>Suppositories</p> Signup and view all the answers

    What is the primary advantage of rectal drug delivery over oral administration?

    <p>Avoidance of first-pass metabolism</p> Signup and view all the answers

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