18 Questions
What is the main purpose of rectal dosage forms intended for local effect?
Managing haemorrhoids
Which type of drugs are commonly included in rectal dosage forms for local effect?
Astringents and local anaesthetics
What is the most commonly used type of rectal dosage form?
Suppositories
How are rectal suppositories described in terms of their preparation?
Single-dose preparations
Which type of bases are commonly used in formulating rectal suppositories for hydrophilic drugs?
Water-soluble bases
What is a key characteristic of the ideal suppository base?
High thermodynamic tendency for drug retention
What is the main reason for the lower rate and extent of drug absorption in the rectum compared to the oral route?
Smaller surface area for absorption
Why is rectal drug delivery considered a safe route of drug administration?
Reduces first-pass metabolism
Why is the rectal route suitable for drugs that are liable to degrade in the gastrointestinal tract (GIT)?
Avoids hepatic first-pass elimination
Which patient group finds rectal dosage forms less acceptable for long-term therapy?
Elderly patients
In rectal drug delivery, what factor can lead to an increase in first-pass metabolism if incorrectly positioned?
Presence of contents in the rectum
Why is rectal drug delivery suitable for pediatric patients?
Avoids hepatic first-pass elimination
Which of the following statements about rectal drug delivery is correct?
The temperature within the rectum is approximately 37°C.
Which of the following conditions is most suitable for rectal drug delivery?
Hemorrhoids
What is the primary mechanism of drug absorption following rectal administration?
Passive diffusion
Which of the following statements is true regarding the pH of rectal fluids?
The pH is approximately 7.2-7.5 in adults and 7.2-12.1 in children.
Which of the following dosage forms is most suitable for rectal drug delivery?
Suppositories
What is the primary advantage of rectal drug delivery over oral administration?
Avoidance of first-pass metabolism
Learn about rectal dosage forms designed for local or systemic effects, including their use in managing conditions like haemorrhoids. Explore the types of drugs commonly used in rectal dosage forms, such as astringents, antiseptics, and local anaesthetics, as well as the various forms these medications come in.
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