RCC: Metastasis and Investigations

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Questions and Answers

What percentage of renal cell carcinoma is sporadic?

90%
96% (correct)
95%
80%

What characteristics are common in familial renal cell carcinoma?

Bilateral and solitary
Unifocal and unilateral
Multifocal and bilateral (correct)
Unilateral and solitary

What is the approximate percentage of familial renal cell carcinoma?

1%
4% (correct)
10%
8%

Which type of renal cell carcinoma is associated with Von Hippel-Lindau Syndrome?

<p>Clear cell carcinoma (D)</p> Signup and view all the answers

What is the molecular pathology of renal cell carcinoma predominantly associated with?

<p>Tumor suppressor genes (A)</p> Signup and view all the answers

Study Notes

Renal Cell Carcinoma (RCC)

Up to 30% of patients with RCC present with metastatic disease, commonly in the bone and lung.
Amyloidosis is a possible associated condition.

Investigations

General investigations for RCC include:
- Complete Blood Count (CBC)
- Erythrocyte Sedimentation Rate (ESR)
- Liver Function Tests (LFTs)

Hereditary Papillary Renal Cell Cancer

Associated with activating mutations of the MET proto-oncogene
Characterized by a papillary growth pattern

Types of Renal Cell Carcinoma

Sporadic RCC: accounts for approximately 96% of cases
Familial RCC: accounts for approximately 4% of cases, characterized by:
- Multifocal tumors
- Bilateral tumors

Other Associated Conditions

Chronic renal failure
Acquired cystic disease

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Description

This quiz covers the presentation of metastatic disease in Renal Cell Carcinoma (RCC) patients, including common metastasis locations and necessary investigations.