5 Questions
What percentage of renal cell carcinoma is sporadic?
96%
What characteristics are common in familial renal cell carcinoma?
Multifocal and bilateral
What is the approximate percentage of familial renal cell carcinoma?
4%
Which type of renal cell carcinoma is associated with Von Hippel-Lindau Syndrome?
Clear cell carcinoma
What is the molecular pathology of renal cell carcinoma predominantly associated with?
Tumor suppressor genes
Study Notes
Renal Cell Carcinoma (RCC)
- Up to 30% of patients with RCC present with metastatic disease, commonly in the bone and lung.
- Amyloidosis is a possible associated condition.
Investigations
- General investigations for RCC include:
- Complete Blood Count (CBC)
- Erythrocyte Sedimentation Rate (ESR)
- Liver Function Tests (LFTs)
Hereditary Papillary Renal Cell Cancer
- Associated with activating mutations of the MET proto-oncogene
- Characterized by a papillary growth pattern
Types of Renal Cell Carcinoma
- Sporadic RCC: accounts for approximately 96% of cases
- Familial RCC: accounts for approximately 4% of cases, characterized by:
- Multifocal tumors
- Bilateral tumors
Other Associated Conditions
- Chronic renal failure
- Acquired cystic disease
This quiz covers the presentation of metastatic disease in Renal Cell Carcinoma (RCC) patients, including common metastasis locations and necessary investigations.
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