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Questions and Answers
What percentage of renal cell carcinoma is sporadic?
What percentage of renal cell carcinoma is sporadic?
What characteristics are common in familial renal cell carcinoma?
What characteristics are common in familial renal cell carcinoma?
What is the approximate percentage of familial renal cell carcinoma?
What is the approximate percentage of familial renal cell carcinoma?
Which type of renal cell carcinoma is associated with Von Hippel-Lindau Syndrome?
Which type of renal cell carcinoma is associated with Von Hippel-Lindau Syndrome?
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What is the molecular pathology of renal cell carcinoma predominantly associated with?
What is the molecular pathology of renal cell carcinoma predominantly associated with?
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Study Notes
Renal Cell Carcinoma (RCC)
- Up to 30% of patients with RCC present with metastatic disease, commonly in the bone and lung.
- Amyloidosis is a possible associated condition.
Investigations
- General investigations for RCC include:
- Complete Blood Count (CBC)
- Erythrocyte Sedimentation Rate (ESR)
- Liver Function Tests (LFTs)
Hereditary Papillary Renal Cell Cancer
- Associated with activating mutations of the MET proto-oncogene
- Characterized by a papillary growth pattern
Types of Renal Cell Carcinoma
- Sporadic RCC: accounts for approximately 96% of cases
- Familial RCC: accounts for approximately 4% of cases, characterized by:
- Multifocal tumors
- Bilateral tumors
Other Associated Conditions
- Chronic renal failure
- Acquired cystic disease
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Description
This quiz covers the presentation of metastatic disease in Renal Cell Carcinoma (RCC) patients, including common metastasis locations and necessary investigations.
