Podcast
Questions and Answers
What is a genetic variant that alters gene function and affects only a small proportion of the population?
What is a genetic variant that alters gene function and affects only a small proportion of the population?
Rare variant
What type of genetic mutations occur after conception?
What type of genetic mutations occur after conception?
De novo mutations
In terms of complex traits, what does the comparison between twin and SNP heritability estimates provide?
In terms of complex traits, what does the comparison between twin and SNP heritability estimates provide?
Useful information
If SNP heritability estimate results are similar to twin results, what does this suggest?
If SNP heritability estimate results are similar to twin results, what does this suggest?
What does a small SNP heritability compared to twin heritability estimates indicate?
What does a small SNP heritability compared to twin heritability estimates indicate?
What is the fastest-moving area of science?
What is the fastest-moving area of science?
Why is it difficult to find associations in Genome-Wide Association studies (GWA)?
Why is it difficult to find associations in Genome-Wide Association studies (GWA)?
What is the 'missing heritability' gap in genetic studies?
What is the 'missing heritability' gap in genetic studies?
What percentage of variance is typically predicted by the largest Genome-Wide Association (GWA) associations per SNP?
What percentage of variance is typically predicted by the largest Genome-Wide Association (GWA) associations per SNP?
What methodology has been developed to address the 'missing heritability' issue in genetic studies?
What methodology has been developed to address the 'missing heritability' issue in genetic studies?
How does sample size impact the ability to detect effects of Single Nucleotide Polymorphisms (SNPs) in genetic studies?
How does sample size impact the ability to detect effects of Single Nucleotide Polymorphisms (SNPs) in genetic studies?
What would have been the conclusion about common SNPs' role in IQ and EA variation if scientists had not pooled resources for larger samples?
What would have been the conclusion about common SNPs' role in IQ and EA variation if scientists had not pooled resources for larger samples?
What is the difference between GCTA SNP heritability and twin study heritability for cognitive abilities?
What is the difference between GCTA SNP heritability and twin study heritability for cognitive abilities?
What does univariate genetic analysis using SNP heritability aim to identify?
What does univariate genetic analysis using SNP heritability aim to identify?
Why does GCTA SNP heritability need extremely large sample sizes?
Why does GCTA SNP heritability need extremely large sample sizes?
What are the limitations of SNP microarrays in univariate genetic analysis?
What are the limitations of SNP microarrays in univariate genetic analysis?
Why does GCTA SNP heritability underestimates heritability?
Why does GCTA SNP heritability underestimates heritability?
What genetic components are not covered by GCTA SNP heritability?
What genetic components are not covered by GCTA SNP heritability?
