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Questions and Answers
Which of the following statements is TRUE about alpha particles?
Which of the following statements is TRUE about alpha particles?
What is the primary reason why alpha particles are considered harmless as an external source?
What is the primary reason why alpha particles are considered harmless as an external source?
Which of the following is NOT characteristic of low-LET radiation?
Which of the following is NOT characteristic of low-LET radiation?
The term "LET" refers to:
The term "LET" refers to:
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Which of the following statements is TRUE about the biological effect of radiation?
Which of the following statements is TRUE about the biological effect of radiation?
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What is the primary difference between X-rays and gamma rays?
What is the primary difference between X-rays and gamma rays?
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Which of the following is a key factor in determining the degree of penetration and energy transfer of ionizing radiation?
Which of the following is a key factor in determining the degree of penetration and energy transfer of ionizing radiation?
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Why are X-rays and gamma rays considered less harmful than alpha particles as external sources?
Why are X-rays and gamma rays considered less harmful than alpha particles as external sources?
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Which of the following accurately reflects the relationship between deterministic and stochastic effects?
Which of the following accurately reflects the relationship between deterministic and stochastic effects?
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Which of the following is an example of a stochastic effect?
Which of the following is an example of a stochastic effect?
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What is the primary reason for the 50 mSv whole-body dose limit?
What is the primary reason for the 50 mSv whole-body dose limit?
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Which of the following does the vertical axis represent on a dose-response curve?
Which of the following does the vertical axis represent on a dose-response curve?
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What is the main difference between a threshold curve and a non-threshold curve on a dose-response graph?
What is the main difference between a threshold curve and a non-threshold curve on a dose-response graph?
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Which type of dose-response curve would best represent the effect of cataracts from radiation exposure?
Which type of dose-response curve would best represent the effect of cataracts from radiation exposure?
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Why would Curve A on a dose-response graph start out higher on the vertical axis compared to Curve B?
Why would Curve A on a dose-response graph start out higher on the vertical axis compared to Curve B?
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Which of the following statements is TRUE about the ALARA philosophy?
Which of the following statements is TRUE about the ALARA philosophy?
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What is the primary function of carbohydrates in the human body?
What is the primary function of carbohydrates in the human body?
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Which of the following correctly describes the composition of lipids?
Which of the following correctly describes the composition of lipids?
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What are enzymes primarily responsible for in the body?
What are enzymes primarily responsible for in the body?
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Which molecule is considered the most abundant in the human body?
Which molecule is considered the most abundant in the human body?
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What is the role of DNA in cells?
What is the role of DNA in cells?
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What ratio of hydrogen to oxygen atoms is found in carbohydrates?
What ratio of hydrogen to oxygen atoms is found in carbohydrates?
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Where is DNA predominantly located within a cell?
Where is DNA predominantly located within a cell?
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How are proteins synthesized in the body?
How are proteins synthesized in the body?
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What are the two types of RNA involved in protein synthesis?
What are the two types of RNA involved in protein synthesis?
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Which statement is true about the metabolic processes in the human body?
Which statement is true about the metabolic processes in the human body?
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Which factor does NOT determine the radiosensitivity of a cell or organ?
Which factor does NOT determine the radiosensitivity of a cell or organ?
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What is the term used when genetic cells undergo division?
What is the term used when genetic cells undergo division?
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What effect can excessive radiation exposure to gonads cause?
What effect can excessive radiation exposure to gonads cause?
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Which type of cell division do somatic cells undergo?
Which type of cell division do somatic cells undergo?
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How can ionizing radiation affect future generations?
How can ionizing radiation affect future generations?
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What describes the effects of radiation that impact the individual exposed to it?
What describes the effects of radiation that impact the individual exposed to it?
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What does RBE stand for in radiation biology?
What does RBE stand for in radiation biology?
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How does the linear energy transfer (LET) of radiation affect biological damage?
How does the linear energy transfer (LET) of radiation affect biological damage?
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What is the RBE of diagnostic x-rays?
What is the RBE of diagnostic x-rays?
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What happens when a large dose of radiation is delivered quickly to the whole body?
What happens when a large dose of radiation is delivered quickly to the whole body?
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What characteristic of the radiation influences RBE?
What characteristic of the radiation influences RBE?
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If radiation is delivered over a prolonged period, how is its effect altered?
If radiation is delivered over a prolonged period, how is its effect altered?
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Which of the following has a lower RBE than diagnostic x-rays?
Which of the following has a lower RBE than diagnostic x-rays?
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What is a consequence of increasing the time between irradiations?
What is a consequence of increasing the time between irradiations?
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What is the primary effect of hyperbaric therapy on avascular tumors?
What is the primary effect of hyperbaric therapy on avascular tumors?
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What is the maximum oxygen enhancement ratio (OER) observed with low LET radiation?
What is the maximum oxygen enhancement ratio (OER) observed with low LET radiation?
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How does the sensitivity to radiation change with age in humans?
How does the sensitivity to radiation change with age in humans?
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Which of the following statements about gender sensitivity to radiation is accurate?
Which of the following statements about gender sensitivity to radiation is accurate?
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What type of chemicals enhance radiation effects in tissues?
What type of chemicals enhance radiation effects in tissues?
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What is the primary drawback of radioprotectors in human applications?
What is the primary drawback of radioprotectors in human applications?
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How does higher LET radiation impact biological damage in tissues?
How does higher LET radiation impact biological damage in tissues?
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Which statement about the photoelectric effect and x-radiation is accurate?
Which statement about the photoelectric effect and x-radiation is accurate?
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Flashcards
DNA sensitivity
DNA sensitivity
DNA is more sensitive to radiation than other cell structures.
Cytoplasm
Cytoplasm
The liquid inside the cell that contains water and organelles.
Types of RNA
Types of RNA
Two types: mRNA and tRNA play key roles in protein synthesis.
Radiosensitivity factors
Radiosensitivity factors
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Cell proliferation types
Cell proliferation types
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Somatic effects
Somatic effects
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Genetic effects
Genetic effects
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Reproductive organs radiosensitivity
Reproductive organs radiosensitivity
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Carbohydrates
Carbohydrates
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Proteins
Proteins
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Lipids
Lipids
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Nucleic Acids
Nucleic Acids
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DNA
DNA
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Homeostasis
Homeostasis
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Metabolism
Metabolism
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Catabolism
Catabolism
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Electromagnetic Radiations
Electromagnetic Radiations
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LET (Linear Energy Transfer)
LET (Linear Energy Transfer)
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Alpha Particles
Alpha Particles
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High LET Radiation
High LET Radiation
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Low LET Radiation
Low LET Radiation
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X-Rays vs Gamma Rays
X-Rays vs Gamma Rays
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Biological Effect of Radiation
Biological Effect of Radiation
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Energy Loss in Alpha Radiation
Energy Loss in Alpha Radiation
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Relative Biologic Effectiveness (RBE)
Relative Biologic Effectiveness (RBE)
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Linear Energy Transfer (LET)
Linear Energy Transfer (LET)
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Ionizing Radiation
Ionizing Radiation
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Radiation Damage Relationship
Radiation Damage Relationship
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RBE of X-rays
RBE of X-rays
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Fractionation
Fractionation
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Protraction
Protraction
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Radiation Dose Factors
Radiation Dose Factors
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Oxygen Enhancement Ratio (OER)
Oxygen Enhancement Ratio (OER)
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Radiosensitizers
Radiosensitizers
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Radioprotectors
Radioprotectors
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Human Age Sensitivity
Human Age Sensitivity
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Gender Sensitivity
Gender Sensitivity
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Interphase Death
Interphase Death
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Stochastic effects
Stochastic effects
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Non-stochastic effects
Non-stochastic effects
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Whole-body dose limit
Whole-body dose limit
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Cataracts induction dose
Cataracts induction dose
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Dose-response curves
Dose-response curves
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Types of dose-response curves
Types of dose-response curves
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Threshold effect
Threshold effect
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Linear dose-response curve
Linear dose-response curve
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Study Notes
Radiation Biology
- Radiation interacts with atoms, causing ionization or excitation, which changes chemical properties.
- Ionization of molecules can lead to breakage or relocation of atoms, potentially causing cell malfunction or death.
- Ionized atoms can revert to a neutral state by attracting free electrons.
- Cells and tissues can regenerate after radiation exposure.
Early Effects of Radiation
- Observed within minutes or days of exposure.
Late Effects of Radiation
- Appear months or years after exposure.
Radiobiology
- The study of radiation effects on biological tissues.
- Aims for accurate descriptions of effects for safer diagnostic and therapeutic use of radiation.
Composition of the Body
- Over 85% of the body is hydrogen and oxygen (H - 60%, O - 25.7%, C - 10.7%, N - 2.4%).
- Radiation interacts with the body at the atomic level.
The Cell Theory
- Cells are the structural and functional units in all plants and animals.
- Cells are composed of molecules such as water, proteins, lipids, carbohydrates, and nucleic acids.
Molecular Composition
- Water makes up approximately 80% of the human body.
- Proteins, lipids, carbohydrates, and nucleic acids are also essential components, at 15%, or approximately 22 types of amino acids linked together by peptide bonds.
- These molecules perform vital functions in the body.
Radiosensitivity of Cells
- Different cell types have different sensitivities to radiation.
- Stem cells and rapidly dividing cells are more sensitive than mature, non-dividing cells.
Law of Bergonie and Tribondeau
- Immature cells, cells with a high mitotic rate, and young tissues are more radiosensitive.
- Mature, specialized cells are less radiosensitive.
- The more highly specialized or mature cells are, and the lower their rate of mitosis(cell division), the more resistant they are to radiation. The more mitotic a cell, the more sensitive it is to radiation.
Linear Energy Transfer (LET)
- Measure of energy deposited by radiation per unit length of tissue.
- High LET radiation deposits energy densely along its path, often causing more damage than low LET radiation.
- Low LET radiation (e.g., X-rays, gamma rays) is highly penetrating but less damaging.
- High LET radiation (e.g., alpha particles, neutrons) deposits energy densely, is less penetrating but more damaging.
- LET is determined by the mass, charge, and velocity of the radiation particle.
Relative Biological Effectiveness (RBE)
- Ability of radiation with different LET to produce biological damage.
- Higher LET radiation has a higher RBE
Fractionation and Protraction
- Fractioning: delivering a dose of radiation in multiple smaller fractions over a longer time reduces damage compared to a single large dose.
Biological Factors Influencing Radiosensitivity
- Oxygen effect: oxygenated tissues are more sensitive to radiation compared with hypoxic tissues. This is because the radicals created due to radiation interact more with oxygen compared to other substances.
- Age, gender, metabolic rate
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Description
Test your knowledge on radiation biology with this quiz. Questions cover topics such as alpha particles, low-LET radiation, and the biological effects of radiation. Enhance your understanding of ionizing radiation and its characteristics.