Radiation Biology: Oxygen Effect and Reoxygenation Chapter 6
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Questions and Answers

What is the approximate Oxygen Enhancement Ratio (OER) for neutrons?

  • 2.0
  • 1.6 (correct)
  • 2.5
  • 1.2

What is the primary factor that determines the extent of radiation-induced DNA damage?

  • Phase of cell cycle
  • Linear energy transfer (LET)
  • Type of radiation (X-rays or neutrons)
  • Presence or absence of oxygen (correct)

What is the minimum time required for oxygen to be present after irradiation to produce the oxygen effect?

  • 1 second
  • 1 microsecond
  • 5 milliseconds (correct)
  • 1 minute

What is the primary mechanism by which oxygen acts to produce the oxygen effect?

<p>Acting at the level of free radicals (C)</p> Signup and view all the answers

What is the characteristic of chronic hypoxia in tumors?

<p>Results from the limited diffusion distance of oxygen through tissue (B)</p> Signup and view all the answers

What is the reason for the smaller OER at low doses compared to high doses in rapidly growing cells?

<p>G1 cells are more radiosensitive than G2 cells and dominate the low-dose region (B)</p> Signup and view all the answers

What is the primary mechanism by which oxygen enhances the effect of radiation?

<p>By 'fixing' the radiation-induced DNA damage (D)</p> Signup and view all the answers

What is the effect of hypoxia on chemoresistance?

<p>It decreases the sensitivity of cells to chemotherapy (B)</p> Signup and view all the answers

What is the Oxygen Enhancement Ratio (OER) equal to?

<p>The ratio of hypoxic to aerobic doses required to achieve the same biological effect (C)</p> Signup and view all the answers

Which of the following types of radiation has an OER of unity?

<p>Alpha particle (A)</p> Signup and view all the answers

What is the effect of linear energy transfer on OER?

<p>It has no effect on the OER (B)</p> Signup and view all the answers

Which of the following cells have a higher OER?

<p>Radiation-resistant cells (B)</p> Signup and view all the answers

What is the primary reason for the development of acute hypoxia in tumors?

<p>Malformed vasculature of the tumor (B)</p> Signup and view all the answers

What is the phenomenon by which hypoxic cells become oxygenated after a dose of radiation?

<p>Reoxygenation (B)</p> Signup and view all the answers

What is the primary mechanism by which hypoxia cell sensitizers increase radiosensitivity of hypoxic cells?

<p>Free-radical formation that mimics oxygen fixation of damage (B)</p> Signup and view all the answers

What is the primary benefit of fractionation in reducing hypoxia in tumors?

<p>Limiting damage to normal tissue (A)</p> Signup and view all the answers

What is the approximate proportion of hypoxic cells in an untreated tumor, as observed by Van Putten and Kallman in mouse sarcoma?

<p>14% (A)</p> Signup and view all the answers

What is the primary advantage of using hypoxia cell sensitizers over increasing oxygen delivery to tumor cells?

<p>Sensitizers are more metabolically stable than O2 (D)</p> Signup and view all the answers

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