PHARMACODYNAMIC AND PHARMACOKINETIC T Or F PAPER 01 ANSWER & EXPLANATIONs
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Questions and Answers

Pharmacodynamics is the study of how the body affects drugs.

False

Pharmacokinetics is the study of how drugs affect the body.

False

The therapeutic window is the range of drug doses that are effective and safe.

True

The therapeutic index measures the safety of a drug by comparing its effective dose to its lethal dose.

<p>True</p> Signup and view all the answers

Onset of action refers to the time it takes for a drug to start producing its effects.

<p>True</p> Signup and view all the answers

Termination of action refers to the process by which the body eliminates a drug.

<p>False</p> Signup and view all the answers

Duration of action is the length of time a drug remains in the body at therapeutic levels.

<p>True</p> Signup and view all the answers

: Absorption is the process by which a drug enters the bloodstream from its site of administration.

<p>True</p> Signup and view all the answers

Distribution refers to how a drug is spread throughout the body's tissues.

<p>True</p> Signup and view all the answers

Metabolism involves the transformation of drugs in the body, often in the liver.

<p>True</p> Signup and view all the answers

Elimination is the removal of drugs from the body, primarily through urine and feces.

<p>True</p> Signup and view all the answers

The therapeutic window can vary among individuals due to genetic factors.

<p>True</p> Signup and view all the answers

A narrow therapeutic index indicates a small margin of safety for a drug.

<p>True</p> Signup and view all the answers

Rapid onset of action is typically seen with intravenous drug administration.

<p>True</p> Signup and view all the answers

The liver plays a key role in drug absorption.

<p>False</p> Signup and view all the answers

Some drugs can be absorbed through the skin, bypassing the digestive system.

<p>True</p> Signup and view all the answers

Distribution is affected by factors such as blood flow and tissue binding.

<p>True</p> Signup and view all the answers

Drug interactions can alter the metabolism of certain medications.

<p>True</p> Signup and view all the answers

Renal excretion is an example of drug elimination through the kidneys.

<p>True</p> Signup and view all the answers

The half-life of a drug is the time it takes for half of the drug to be eliminated from the body.

<p>True</p> Signup and view all the answers

Tolerance to a drug can develop over time, requiring higher doses for the same effect.

<p>True</p> Signup and view all the answers

Drug bioavailability is influenced by factors such as food intake.

<p>True</p> Signup and view all the answers

Some drugs can cross the blood-brain barrier, affecting the central nervous system.

<p>True</p> Signup and view all the answers

Cytochrome P450 enzymes are involved in drug metabolism.

<p>True</p> Signup and view all the answers

Renal impairment can lead to altered drug elimination.

<p>True</p> Signup and view all the answers

Topical medications are primarily absorbed through the gastrointestinal tract.

<p>False</p> Signup and view all the answers

The therapeutic window of a drug is always the same for every patient.

<p>False</p> Signup and view all the answers

Drug-drug interactions can result in increased or decreased therapeutic effects.

<p>True</p> Signup and view all the answers

Sublingual administration allows for rapid absorption through the oral mucosa.

<p>True</p> Signup and view all the answers

The peak plasma concentration of a drug occurs when absorption equals elimination.

<p>True</p> Signup and view all the answers

First-pass metabolism occurs when a drug is metabolized before entering the systemic circulation.

<p>True</p> Signup and view all the answers

Intramuscular injections have a slower onset of action compared to intravenous injections.

<p>True</p> Signup and view all the answers

Biotransformation of drugs can lead to the formation of active or inactive metabolites.

<p>True</p> Signup and view all the answers

Some drugs require specific pH conditions in the stomach for optimal absorption.

<p>True</p> Signup and view all the answers

The therapeutic index is a static measurement that does not change with dose.

<p>False</p> Signup and view all the answers

Drug excretion can occur through the lungs via exhaled air.

<p>True</p> Signup and view all the answers

Drug absorption is typically slower when taken with a full meal.

<p>True</p> Signup and view all the answers

The volume of distribution is a measure of how extensively a drug is distributed in the body.

<p>True</p> Signup and view all the answers

Drug elimination is the same for all individuals, regardless of their health status.

<p>False</p> Signup and view all the answers

Some drugs can be eliminated in their unchanged form through bile.

<p>True</p> Signup and view all the answers

Intranasal drug administration can lead to rapid drug absorption through the nasal mucosa.

<p>True</p> Signup and view all the answers

Drug metabolism is primarily a function of the kidneys.

<p>False</p> Signup and view all the answers

The therapeutic window is wider for drugs with a high therapeutic index.

<p>True</p> Signup and view all the answers

Drug accumulation can occur with repeated dosing if elimination is slower than absorption.

<p>True</p> Signup and view all the answers

In pharmacokinetics, the "Cmax" represents the maximum drug concentration in the bloodstream.

<p>True</p> Signup and view all the answers

The bioavailability of a drug is 100% when administered intravenously.

<p>True</p> Signup and view all the answers

Drug interactions can be both pharmacokinetic and pharmacodynamic in nature.

<p>True</p> Signup and view all the answers

Lipophilic drugs tend to have longer durations of action.

<p>True</p> Signup and view all the answers

Drug half-life is the same for all drugs, regardless of their properties.

<p>False</p> Signup and view all the answers

Drug transporters in the body can influence drug distribution and elimination.

<p>True</p> Signup and view all the answers

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