QSEN Alert: Nitroglycerin Tolerance and Safety

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Questions and Answers

What is the effect of dilation of the veins on blood flow?

  • Decreases filling pressure (preload) (correct)
  • Decreases blood pressure
  • Increases cardiac output
  • Increases blood return to the heart

How do nitrates affect the systemic arteriolar bed?

  • They have no effect on arterioles
  • They relax the arteriolar bed, lowering blood pressure (correct)
  • They increase afterload
  • They constrict the arterioles

What is the purpose of applying topical nitroglycerin patches in the morning and removing them at bedtime?

  • To prevent the development of tolerance (correct)
  • To decrease myocardial oxygen requirements
  • To achieve a continuous high level of nitrate in the body
  • To alleviate pain of ischemia within 3 minutes

How do beta-blockers reduce myocardial oxygen consumption?

<p>By blocking beta-adrenergic sympathetic stimulation to the heart (C)</p> Signup and view all the answers

Why should beta-blocker therapy not be stopped abruptly?

<p>Because it may worsen angina and lead to MI (B)</p> Signup and view all the answers

What is the primary effect of calcium channel blockers on the ischemic myocardium?

<p>Decrease the workload of the heart (B)</p> Signup and view all the answers

Which drug is commonly prescribed in addition to aspirin in patients at high risk for MI?

<p>Heparin (A)</p> Signup and view all the answers

What is the main mechanism by which nitroglycerin relieves angina?

<p>Venous dilation (C)</p> Signup and view all the answers

What is the risk associated with both clopidogrel and newer oral agents such as prasugrel and ticagrelor?

<p>Bleeding from the GI tract or other sites (D)</p> Signup and view all the answers

What is the indication for IV administration of glycoprotein IIb/IIIa agents, such as abciximab or eptifibatide?

<p>As adjunct therapy for PCI (C)</p> Signup and view all the answers

How is heparin therapy considered therapeutic?

<p>When the activated partial thromboplastin time (aPTT) is 2 to 2.5 times the normal value (C)</p> Signup and view all the answers

How are organic nitrates like nitroglycerin converted in the body?

<p>Converted to a vasodilator (D)</p> Signup and view all the answers

Which of the following best describes the action of antianginal drugs?

<p>Dilating blood vessels to increase oxygen supply (C)</p> Signup and view all the answers

What influences the demand for oxygen by the heart muscle?

<p>Heart rate and preload (B)</p> Signup and view all the answers

Which drug is described as a potent vasodilator that improves blood flow to the heart muscle?

<p>Nitrates (C)</p> Signup and view all the answers

What type of vessels does nitroglycerin primarily dilate?

<p>Veins (A)</p> Signup and view all the answers

Which of the following is NOT an influence on the demand for oxygen by the heart muscle?

<p>Body temperature (B)</p> Signup and view all the answers

What is the primary purpose of nitrates in angina treatment?

<p>Improving blood flow to the heart muscle (A)</p> Signup and view all the answers

What is the purpose of observing a 10- to 12-hour nitrate-free interval?

<p>To prevent the development of tolerance to nitroglycerin (C)</p> Signup and view all the answers

When is the oral form of nitroglycerin useful?

<p>For prophylactic use in chronic chest pain (B)</p> Signup and view all the answers

In which situation is IV nitroglycerin useful according to the text?

<p>Controlling blood pressure in perioperative or emergency situations (C)</p> Signup and view all the answers

What is the most common adverse effect of nitroglycerin?

<p>Severe headache (C)</p> Signup and view all the answers

What are the contraindications to nitroglycerin according to the text?

<p>Hypersensitivity reactions and hypotension (C)</p> Signup and view all the answers

What should the nurse do if a patient has hypotension and tachycardia prior to administering nitroglycerin?

<p>Withhold the medication (A)</p> Signup and view all the answers

What is the recommended action if chest pain is not relieved within 5 minutes of taking sublingual nitroglycerin tablets?

<p>Dissolve a second tablet under the tongue (B)</p> Signup and view all the answers

What should be done if withdrawal of a beta-adrenergic blocker is planned?

<p>Gradually decrease the dose under prescriber's guidance (D)</p> Signup and view all the answers

How should transmucosal tablets of nitroglycerin be administered?

<p>Place them under the upper lip or between the cheek and gum and allow them to dissolve slowly (C)</p> Signup and view all the answers

What is important to remember about applying nitroglycerin patches and ointment?

<p>Rotate application sites to promote effective and consistent drug absorption (A)</p> Signup and view all the answers

What should be avoided when taking nitroglycerin and other nitrate preparations?

<p>Taking medications for erectile dysfunction (D)</p> Signup and view all the answers

How should oral nitrates be taken?

<p>On an empty stomach with a glass of water (A)</p> Signup and view all the answers

What should be done if heart rate falls below 55 beats/min while taking beta-adrenergic blockers?

<p>Report to the health care provider (D)</p> Signup and view all the answers

How should atenolol be taken?

<p>At the same time each day (C)</p> Signup and view all the answers

What should be done if withdrawal of a beta-adrenergic blocker is planned by the prescriber?

<p>Gradually decrease the dose under prescriber's guidance (D)</p> Signup and view all the answers

What should be done when taking drugs for heart disease on a regular schedule?

<p>Take them at evenly spaced intervals to increase drug effectiveness in preventing acute attacks of angina (D)</p> Signup and view all the answers

What should patients avoid while using nitrate drugs?

<p>Alcohol consumption (D)</p> Signup and view all the answers

How should nitroglycerin ointment be applied to the skin?

<p>By spreading in a thin, even layer on a nonhairy area of the skin (B)</p> Signup and view all the answers

What is the recommended administration route for IV nitroglycerin?

<p>Infusion pump (C)</p> Signup and view all the answers

When should extended-release oral nitrate preparations be used post-MI?

<p>If angina persists after revascularization (B)</p> Signup and view all the answers

What happens if sublingual nitroglycerin tablets are exposed to body heat for a prolonged period?

<p>They become ineffective (A)</p> Signup and view all the answers

What effect may occur with nitrate antianginal drugs, especially sublingual nitroglycerin?

<p>Headache and dizziness (C)</p> Signup and view all the answers

Which of the following is the primary effect of nitroglycerin?

<p>Dilating veins and arteries (C)</p> Signup and view all the answers

What is the primary influence on the demand for oxygen by the heart muscle?

<p>Heart rate (B)</p> Signup and view all the answers

What is the main mechanism by which beta-adrenergic blockers reduce myocardial oxygen consumption?

<p>Decreasing the work of the heart (C)</p> Signup and view all the answers

What is the purpose of observing a 10- to 12-hour nitrate-free interval?

<p>To avoid tolerance to nitrates (B)</p> Signup and view all the answers

Which drug is commonly prescribed in addition to aspirin in patients at high risk for MI?

<p>Calcium channel blockers (B)</p> Signup and view all the answers

How do antianginal drugs primarily work to improve blood delivery to the heart muscle?

<p>By dilating blood vessels or decreasing the work of the heart (B)</p> Signup and view all the answers

Which effect do beta-blockers have on the heart?

<p>Decrease heart rate and myocardial contractility (A)</p> Signup and view all the answers

What is the primary purpose of calcium channel blockers in the treatment of angina?

<p>Decrease workload of the heart and decrease myocardial oxygen demand (C)</p> Signup and view all the answers

What is the recommended dose of aspirin for a patient with a new diagnosis of angina?

<p>162 mg daily (A)</p> Signup and view all the answers

What is a common adverse effect of nitroglycerin?

<p>Headache (D)</p> Signup and view all the answers

What should patients taking beta-blockers do if the prescriber plans to discontinue the medication?

<p>Gradually decrease the dose over several days (B)</p> Signup and view all the answers

Which patient condition is a contraindication for IV administration of nitroglycerin?

<p>Systolic blood pressure less than 90 mm Hg (B)</p> Signup and view all the answers

What is the primary purpose of administering IV administration of glycoprotein IIb/IIIa agents, such as abciximab or eptifibatide?

<p>To block the GP IIb/IIIa receptors on platelets and prevent adhesion of fibrinogen (D)</p> Signup and view all the answers

What is the main risk associated with both clopidogrel and newer oral agents such as prasugrel and ticagrelor?

<p>Bleeding from the gastrointestinal tract or other sites (A)</p> Signup and view all the answers

What is the primary effect of calcium channel blockers on the ischemic myocardium?

<p>Vasodilation and reduction in peripheral vascular resistance (D)</p> Signup and view all the answers

How is heparin therapy considered therapeutic?

<p>When the activated partial thromboplastin time (aPTT) is 2 to 2.5 times the normal value (B)</p> Signup and view all the answers

What is the main mechanism by which nitroglycerin relieves angina?

<p>By reducing venous pressure and decreasing venous return to the heart (C)</p> Signup and view all the answers

What should be done if a patient has received heparin within the past 3 months or has been receiving unfractionated heparin for 4 to 14 days?

<p>Switch to low-molecular-weight heparin (LMWH) (A)</p> Signup and view all the answers

What is the purpose of observing a 10- to 12-hour nitrate-free interval?

<p>To prevent the development of tolerance to nitroglycerin (D)</p> Signup and view all the answers

In which situation is IV nitroglycerin useful according to the text?

<p>To manage pain associated with an MI when unresponsive to other forms of nitrates (A)</p> Signup and view all the answers

What is the most common adverse effect of nitroglycerin?

<p>Severe headache (D)</p> Signup and view all the answers

What should be done if a patient has hypotension and tachycardia prior to administering nitroglycerin?

<p>Withhold the medication and monitor the patient closely (C)</p> Signup and view all the answers

What is important to remember about administering SL nitroglycerin or translingual spray?

<p>It should be used as soon as chest pain develops (C)</p> Signup and view all the answers

What drugs interact with nitroglycerin, increasing or decreasing its effects?

<p>Calcium channel blockers and alcohol (B)</p> Signup and view all the answers

Why should nitroglycerin ointment not be massaged into the patient's skin?

<p>It increases the absorption of the ointment (A)</p> Signup and view all the answers

Why do patients take PO nitrates in the morning after a nitrate-free interval?

<p>To prevent tolerance development (D)</p> Signup and view all the answers

Why should extended-release oral nitrate preparations be used post-MI if angina persists after revascularization?

<p>To maintain long-term control of angina (B)</p> Signup and view all the answers

Why is it important to avoid PVC tubing when administering IV nitroglycerin?

<p>PVC tubing absorbs a significant amount of the drug (C)</p> Signup and view all the answers

What should patients do if rest and three sublingual tablets or oral sprays do not relieve chest pain?

<p>Seek emergency care immediately (D)</p> Signup and view all the answers

What is a potential side effect that may occur with nitrate antianginal drugs, especially sublingual nitroglycerin?

<p>Temporary headache (B)</p> Signup and view all the answers

What should be done if chest pain is not relieved within 5 minutes of taking sublingual nitroglycerin tablets?

<p>Dissolve a second tablet under the tongue (D)</p> Signup and view all the answers

What should patients avoid while using nitrate drugs?

<p>Erectile dysfunction medications (B)</p> Signup and view all the answers

How should transmucosal tablets of nitroglycerin be administered?

<p>Place them under the tongue until they dissolve (C)</p> Signup and view all the answers

Why should beta-blocker therapy not be stopped abruptly?

<p>To avoid rebound tachycardia (A)</p> Signup and view all the answers

What is the primary influence on the demand for oxygen by the heart muscle?

<p>Myocardial oxygen consumption (C)</p> Signup and view all the answers

How are organic nitrates like nitroglycerin converted in the body?

<p>They are converted to nitric oxide (A)</p> Signup and view all the answers

What is the main mechanism by which nitroglycerin relieves angina?

<p>Dilating blood vessels (D)</p> Signup and view all the answers

What is the primary purpose of nitrates in angina treatment?

<p>To reduce myocardial oxygen demand (D)</p> Signup and view all the answers

Which drug is commonly prescribed in addition to aspirin in patients at high risk for MI?

<p>Clopidogrel (D)</p> Signup and view all the answers

What are the contraindications to nitroglycerin according to the text?

<p>Use of erectile dysfunction medications (D)</p> Signup and view all the answers

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