Podcast
Questions and Answers
What is the first cell type in the formation of agranulocytes?
What is the first cell type in the formation of agranulocytes?
- Myeloid Stem Cell
- Lymphoblast
- Monocyte
- Hemocytoblast (correct)
Which type of stem cell gives rise to monocytes?
Which type of stem cell gives rise to monocytes?
- Mesenchymal Stem Cell
- Erythroid Stem Cell
- Myeloid Stem Cell (correct)
- Lymphoid Stem Cell
What is the primary characteristic of leukemia?
What is the primary characteristic of leukemia?
- Cancerous conditions involving leukocytes (correct)
- Normal function of bone marrow
- Increased red blood cell production
- Increase in platelet count
What is the hormone that regulates platelet formation?
What is the hormone that regulates platelet formation?
Which of the following is a symptom of infectious mononucleosis?
Which of the following is a symptom of infectious mononucleosis?
What role do platelets play in the body?
What role do platelets play in the body?
What is a known effect of leukopenia?
What is a known effect of leukopenia?
What type of cell fragments form thrombocytes?
What type of cell fragments form thrombocytes?
What initiates the extrinsic pathway of coagulation?
What initiates the extrinsic pathway of coagulation?
Which phase of coagulation involves the conversion of prothrombin into thrombin?
Which phase of coagulation involves the conversion of prothrombin into thrombin?
What is the primary role of fibrin threads in the clotting process?
What is the primary role of fibrin threads in the clotting process?
Which proteins do platelets contain that contribute to clot retraction?
Which proteins do platelets contain that contribute to clot retraction?
What enzyme is responsible for digesting blood clots during the fibrinolysis process?
What enzyme is responsible for digesting blood clots during the fibrinolysis process?
How long after clot formation does fibrinolysis typically begin?
How long after clot formation does fibrinolysis typically begin?
What is the main function of the fibrin threads during clot formation?
What is the main function of the fibrin threads during clot formation?
Which mechanism helps to maintain homeostasis and prevent excessive clotting?
Which mechanism helps to maintain homeostasis and prevent excessive clotting?
What is the first stage in the development of blood cells from hemocytoblasts?
What is the first stage in the development of blood cells from hemocytoblasts?
Which statement is true about normoblasts?
Which statement is true about normoblasts?
What role do reticulocytes play in the bloodstream?
What role do reticulocytes play in the bloodstream?
What effect does excess oxygen or too many erythrocytes have on erythropoietin production?
What effect does excess oxygen or too many erythrocytes have on erythropoietin production?
How long does it take for reticulocytes to mature into erythrocytes?
How long does it take for reticulocytes to mature into erythrocytes?
What percentage of all erythrocytes do reticulocytes account for in a healthy human?
What percentage of all erythrocytes do reticulocytes account for in a healthy human?
What can cause hypoxia, leading to an increase in erythropoietin production?
What can cause hypoxia, leading to an increase in erythropoietin production?
What is the typical rate of erythrocyte production in healthy individuals?
What is the typical rate of erythrocyte production in healthy individuals?
What is the primary function of the conducting zone in the respiratory system?
What is the primary function of the conducting zone in the respiratory system?
Which of the following structures does NOT belong to the conducting zone?
Which of the following structures does NOT belong to the conducting zone?
What is the primary role of goblet cells in the respiratory mucosa?
What is the primary role of goblet cells in the respiratory mucosa?
How does the respiratory mucosa help in preparing air for the lungs?
How does the respiratory mucosa help in preparing air for the lungs?
What is the relationship between flow rate and resistance in the cardiovascular system?
What is the relationship between flow rate and resistance in the cardiovascular system?
Which bones contain the paranasal sinuses that aid in warming and moistening incoming air?
Which bones contain the paranasal sinuses that aid in warming and moistening incoming air?
What drives blood flow from one region to another in the cardiovascular system?
What drives blood flow from one region to another in the cardiovascular system?
What occurs during rhinitis?
What occurs during rhinitis?
What is the function of capillaries located beneath the respiratory mucosa?
What is the function of capillaries located beneath the respiratory mucosa?
What defines the Mean Arterial Pressure (MAP)?
What defines the Mean Arterial Pressure (MAP)?
What is epistaxis and what commonly causes it?
What is epistaxis and what commonly causes it?
If the Central Venous Pressure (CVP) is 5 mmHg and the Mean Arterial Pressure (MAP) is 85 mmHg, what is the pressure gradient driving blood flow through the systemic circulation?
If the Central Venous Pressure (CVP) is 5 mmHg and the Mean Arterial Pressure (MAP) is 85 mmHg, what is the pressure gradient driving blood flow through the systemic circulation?
What role does the heart play in the cardiovascular system?
What role does the heart play in the cardiovascular system?
What happens to blood flow if the pressure gradient driving it is low?
What happens to blood flow if the pressure gradient driving it is low?
Which statement accurately describes pressure in the cardiovascular system?
Which statement accurately describes pressure in the cardiovascular system?
What is the likely effect of increased resistance on blood flow rate?
What is the likely effect of increased resistance on blood flow rate?
What happens when the net filtration pressure (NFP) is positive?
What happens when the net filtration pressure (NFP) is positive?
Which of the following best describes the primary function of the valves in veins?
Which of the following best describes the primary function of the valves in veins?
What is true about the walls of veins compared to arteries?
What is true about the walls of veins compared to arteries?
Which condition is least likely to affect fluid levels in tissues?
Which condition is least likely to affect fluid levels in tissues?
What does high compliance in veins mean?
What does high compliance in veins mean?
Which pressure is primarily related to fluid outside of a capillary?
Which pressure is primarily related to fluid outside of a capillary?
What do veins primarily serve as within the circulatory system?
What do veins primarily serve as within the circulatory system?
At which end of a capillary does absorption occur?
At which end of a capillary does absorption occur?
Flashcards
Capillary Hydrostatic Pressure (PCAP)
Capillary Hydrostatic Pressure (PCAP)
The pressure exerted by blood within a capillary, essentially the capillary blood pressure.
Interstitial Fluid Hydrostatic Pressure (PIF)
Interstitial Fluid Hydrostatic Pressure (PIF)
The pressure exerted by fluid outside of a capillary.
Colloid Osmotic Pressure
Colloid Osmotic Pressure
The pressure created by proteins in the blood, drawing fluid back into the capillaries.
Net Filtration Pressure (NFP)
Net Filtration Pressure (NFP)
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Positive NFP
Positive NFP
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Negative NFP
Negative NFP
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Venules
Venules
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Veins
Veins
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Erythropoiesis
Erythropoiesis
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Hemocytoblast
Hemocytoblast
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Proerythroblast
Proerythroblast
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Erythroblast
Erythroblast
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Normoblast
Normoblast
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Reticulocyte
Reticulocyte
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Erythropoietin (EPO)
Erythropoietin (EPO)
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Hypoxia
Hypoxia
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Blood Flow Rate
Blood Flow Rate
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Pressure Gradient
Pressure Gradient
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Resistance
Resistance
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How does resistance affect flow?
How does resistance affect flow?
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Mean Arterial Pressure (MAP)
Mean Arterial Pressure (MAP)
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Central Venous Pressure (CVP)
Central Venous Pressure (CVP)
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How does the heart create blood flow?
How does the heart create blood flow?
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What is the pressure gradient in systemic circulation?
What is the pressure gradient in systemic circulation?
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Agranulocyte Formation
Agranulocyte Formation
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Lymphoid Stem Cell
Lymphoid Stem Cell
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Leukopenia
Leukopenia
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Leukemia
Leukemia
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Infectious Mononucleosis
Infectious Mononucleosis
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Thrombocyte Formation
Thrombocyte Formation
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Thrombopoietin
Thrombopoietin
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Platelets & Blood Clotting
Platelets & Blood Clotting
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Respiratory Zone
Respiratory Zone
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Conducting Zone
Conducting Zone
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What do goblet cells do?
What do goblet cells do?
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What is rhinitis?
What is rhinitis?
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What is sinusitis?
What is sinusitis?
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What can happen if the adenoids are enlarged?
What can happen if the adenoids are enlarged?
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Nasopharynx
Nasopharynx
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Pharynx
Pharynx
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Coagulation Phases
Coagulation Phases
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Intrinsic Pathway
Intrinsic Pathway
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Extrinsic Pathway
Extrinsic Pathway
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Prothrombin Activator
Prothrombin Activator
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Thrombin
Thrombin
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Fibrin
Fibrin
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Clot Retraction
Clot Retraction
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Fibrinolysis
Fibrinolysis
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Study Notes
Blood Vessels, Blood Pressure and Blood Flow
- Blood flow rate is determined by the pressure gradient across the vessel and inversely related to resistance.
- Flow = Pressure gradient/Resistance
- Increased resistance decreases flow rate.
- Decreased resistance increases flow rate.
- Pressure gradient drives blood flow from higher to lower pressure.
- The heart is the primary pump, creating pressure gradients.
- Mean Arterial Pressure (MAP) — average pressure in the aorta (approximately 85 mm Hg).
- Central Venous Pressure (CVP) — pressure in large veins returning to the heart (approximately 2-8 mmHg).
Pressure Gradient Differences
- Pressure gradient drives blood flow in the systemic circulation.
- The pressure gradient is equated to the Mean Arterial Pressure (MAP).
- Resistance in the cardiovascular system must be low to have a sufficient pressure gradient.
Resistance in the Cardiovascular System
- Resistance refers to any condition that reduces blood flow.
- Vessel radius; a decrease increases resistance (vasoconstriction), and an increase decreases resistance (vasodilation).
- Vessel length.
- Blood viscosity.
- The primary determinant of blood velocity is the total cross-sectional area of the vessel.
Overview of Blood Vessels
- Blood vessels are classified by their direction (away from or toward the heart) and size.
- Arteries and arterioles carry oxygenated blood away from the heart.
- Venules and veins carry deoxygenated blood to the heart.
Arteries
- Arterial walls have three layers (tunics):
- Tunica interna (intima).
- Tunica media.
- Tunica externa (adventitia).
- Tunica media is largely composed of smooth muscle and elastic connective tissue.
Capillaries
- Capillaries are the smallest blood vessels (1µm in diameter).
- They are thin walled, making them highly permeable to substances.
- There are three types of capillaries: continuous, fenestrated, and sinusoidal.
- The density of capillaries in a tissue is related to its metabolic activity.
Veins
- Veins have a larger diameter than arteries.
- The walls of veins are thinner than artery walls.
- Veins typically contain valves to prevent backflow of blood.
- Veins serve as volume reservoirs, holding more blood than arteries.
Blood Pressure and Blood Flow to Organs
- Blood flow to organs is regulated locally based on their metabolic needs.
- Intrinsic control regulates blood flow based on metabolic activity. This is done using locally secreted chemical messengers.
- Active hyperemia involves increased blood flow to an organ in response to increased metabolic activity.
- Active hyperemia causes vasodilation-increasing blood flow.
Regulation of Blood Flow and Pressure
- Intrinsic control of blood flow:
- Blood flow to an organ is locally regulated by chemical messengers, such as nitric oxide, adenosine and prostacyclin.
- Extrinsic control:
- Blood flow is regulated by the autonomic nervous system and hormones.
- Epinephrine/norepinephrine constricts peripheral arterioles.
- Epinephrine/norepinephrine dilates coronary blood vessels.
- Vasopressin constricts many blood vessels.
- Angiotensin II constricts many blood vessels.
Blood Composition
- Plasma (liquid component):
- Primarily water (over 90%).
- Proteins (e.g., albumin, globulins)
- Other substances (e.g., electrolytes, nutrients).
- Formed elements (cells):
- Erythrocytes (red blood cells): Transport oxygen.
- Leukocytes (white blood cells): Defend against infection.
- Platelets: Involved in clotting.
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