Respiratory Tract Infections

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Questions and Answers

Where does Q fever come from?

  • Farm animals (correct)
  • Wild animals
  • Insects
  • Humans

What does Psittacosis come from?

  • Mammals
  • Parrots and other birds (correct)
  • Reptiles
  • Fish

Which of the following are frequent sites of infection? (Select all that apply)

  • Mastoid cavity (correct)
  • Middle ear (correct)
  • Nasal sinuses (correct)
  • Nasopharynx (correct)

What are the most dangerous fungal infections? (Select all that apply)

<p>Aspergillus (A), Pneumocystis jirovecii (D)</p> Signup and view all the answers

Which bacterial species can cause otitis, sinusitis, and mastoiditis?

<p>Streptococcus pneumoniae (A), Hemophilius influenzae (B), Staphylococcus aureus (C), Group A streptococci (D)</p> Signup and view all the answers

What organisms can cause Pharyngitis? (Select all that apply)

<p>Streptococci (Group A and C) (A), Cornyebacterium diphtheriae (B), Chlamydophilia pneumoniae (C), Mycoplasma pneumoniae (D)</p> Signup and view all the answers

Which organism causes strep throat?

<p>Streptococcus pyogenes (A)</p> Signup and view all the answers

Which organism has the following description:

  • Contains M proteins which inhibit phagocytosis
  • Produces pyrogenic toxins which cause the symptoms seen with pharyngitis?

<p>Streptococcus pyogenes (A)</p> Signup and view all the answers

What does Group A streptococcus cause on the tonsils?

<p>abscesses (B)</p> Signup and view all the answers

What causes scarlet fever and scarlet syndrome?

<p>S. pyogenes (A)</p> Signup and view all the answers

What else can streptococcal pyrogenic toxin cause? (Select all that apply)

<p>Scarlet fever rash (A), Toxic shock syndrome (B)</p> Signup and view all the answers

Which of the following are streptolysins? (Select all that apply)

<p>Streptolysin O (B), Streptolysin S (D)</p> Signup and view all the answers

Which population is scarlet fever usually seen in?

<p>Children under 18 years of age (C)</p> Signup and view all the answers

What do scarlet fever symptoms begin with?

<p>Rash (C)</p> Signup and view all the answers

Which of the following pathologies has the listed symptoms:

-Sore throat with yellow or white papules

  • Fever 101 degrees or higher
  • Lymphadenopathy in neck
  • Headache, body aches and nausea?

<p>Scarlet fever (A)</p> Signup and view all the answers

What makes diphtheria life threatening?

<p>Toxemia (B)</p> Signup and view all the answers

What can diphtheria toxemia cause?

<p>Acute myocarditis (A)</p> Signup and view all the answers

How is diphtheria transmitted?

<p>Droplet aerosol (A), Direct contact with skin (B), Fomites (C)</p> Signup and view all the answers

What are the components of the diphtheria exotoxins?

<p>B chain (A), A chain (C)</p> Signup and view all the answers

Which of the following organisms has the following description: small gram-positive bacillus and poorly invasive (effects due to exotoxin)?

<p>Corynebacterium diphtheriae (D)</p> Signup and view all the answers

Which diphtheria exotoxin is used for entry into the target cell?

<p>B chain (A)</p> Signup and view all the answers

Which diphtheria exotoxin displays inhibition of protein synthesis?

<p>A chain (B)</p> Signup and view all the answers

What is the pseudomembrane of diphtheria composed of? (Select all that apply)

<p>Fibrin (A), Leukocytes (B), Cell debris (C)</p> Signup and view all the answers

What does diphtheria present with? (Select all that apply)

<p>pharyngitis (A), tonsillitis (B), fever (C)</p> Signup and view all the answers

Where does the diphtheria pseudomembrane develop? (Select all that apply)

<p>Tonsils (A), Uvula (B), Soft palate (C), Pharyngeal wall (D)</p> Signup and view all the answers

What are complicated diphtheria cases due to?

<p>Respiratory obstruction (A)</p> Signup and view all the answers

What is a systemic infection associated with diphtheria?

<p>myocarditis (B)</p> Signup and view all the answers

What are characteristics of diphtheria skin infections?

<p>Pustules or chronic non-healing ulceration (A)</p> Signup and view all the answers

What is most important in diphtheria treatment?

<p>Toxin neutralization (A)</p> Signup and view all the answers

What can neutralize the free toxin in Diphtheria?

<p>Antitoxin (C)</p> Signup and view all the answers

Corynebacterium diphtheriae is sensitive to many antibiotics.

<p>False (B)</p> Signup and view all the answers

Which of the following are viral infections of the upper respiratory tract?

<p>Rhinovirus (A), Parainfluenza virus (B)</p> Signup and view all the answers

What is the most common cold virus?

<p>Rhinovirus (A)</p> Signup and view all the answers

What are 50% of rhinoviruses characterized as?

<p>Picornavirus (A)</p> Signup and view all the answers

Which of the following is described below: Very small, non-enveloped, ssRNA virus?

<p>Rhinovirus (C)</p> Signup and view all the answers

How many types of parainfluenza viruses are there?

<p>4 (D)</p> Signup and view all the answers

What do all parainfluenza viruses have in common?

<p>Paramyxovirus group (A), ssRNA (B), Contain hemagglutinin and neuraminidase (C)</p> Signup and view all the answers

What differentiates parainfluenza from influenza?

<p>It replicates in the cytoplasm (A), More stable than influenza: no shift or drift, no mutations (B)</p> Signup and view all the answers

There is no treatment for parainfluenza viruses.

<p>True (A)</p> Signup and view all the answers

Which parainfluenza type has the following description:

-Major cause of laryngotracheitis (acute croup) in infants and young children

  • Causes severe upper respiratory illness (pharyngitis and tracheobronchitis) in all age groups
  • Outbreaks usually occur in fall?

<p>Type 1 (A)</p> Signup and view all the answers

Which parainfluenza virus type has the following description:

-Major cause of severe lower respiratory infection in infants and young children

  • Causes bronchitis and pneumonia in children less than one year of age
  • Infections occur throughout the year
  • 50% of all children are exposed to virus during 1st year of life?

<p>Type 3 (C)</p> Signup and view all the answers

What are the 4 stages of classic lobar pneumonia?

<p>Acute, red, grey, resolution (A)</p> Signup and view all the answers

Match each classic lobar pneumonia stage to its description

<p>Acute congestion = Local capillaries engorged with neutrophils Red hepatization = RBC from capillaries flow into alveolar spaces Grey hepatization = Dead neutrophils and degenerating RBC Resolution = Antibodies produced and help control infection</p> Signup and view all the answers

What does community-acquired pneumonia usually present as?

<p>Lobar pneumonia (B)</p> Signup and view all the answers

What can community acquired pneumonia progress into?

<p>Abscesses (C)</p> Signup and view all the answers

Which species cause typical community-acquired pneumonia? (Select all that apply)

<p>Haemophilus influenzae (B), Streptococcus pneumoniae (C), Staphylococcus aureus (D)</p> Signup and view all the answers

Which species cause atypical community acquired pneumonia? (Select all that apply)

<p>Mycoplasma pneumoniae (A), Legionella pneumophilia (B), Chlamydophilia pneumoniae and Chlamydophilia psittaci (C), Coxiella burnetti (D)</p> Signup and view all the answers

What are some characteristics of atypical pneumonia? (Select all that apply)

<p>Milder symptoms (A), Coughing without sputum (C)</p> Signup and view all the answers

Match each pneumonia type to its description

<h1>Lobar pneumonia = Involves single lobe; unilateral; air bronchogram Interstitial pneumonia = Involves interstitial space; Ground glass appearance; bilateral; symmetrical Bronchopneumonia = central bronchi involved; patchy bilateral disease; asymmetrical; peribronchial cuffing</h1> Signup and view all the answers

Which species can cause both community-acquired and nosocomial pneumonia?

<p>Chlamydia pneumoniae (A)</p> Signup and view all the answers

What is the treatment for Chlamydia pneumoniae? (Select all that apply)

<p>Tetracycline (A), Erythromycin (B)</p> Signup and view all the answers

What causes walking pneumonia and 30% of all teenage pneumonias?

<p>Mycoplasma pneumoniae (C)</p> Signup and view all the answers

What can mycoplasma pneumonia cause?

<p>Mild tracheobronchitis (A)</p> Signup and view all the answers

Which of the following is described: -Gram negative rod -Ubiquitous in fresh water -Transmitted to humans as a humidified aerosol -Facultative intracellular parasite?

<p>Legionella pneumophila (C)</p> Signup and view all the answers

Which of the following uses Acanthamoeba as a reservoir?

<p>Legionella pneumophila (B)</p> Signup and view all the answers

Which pathogen enters alveoli to infect macrophages and produces endocytic vesicles?

<p>Legionella pneumophila (B)</p> Signup and view all the answers

What does debilitation in nosocomial pneumonia cause?

<p>Increase in proteolytic enzymes in saliva (A)</p> Signup and view all the answers

What is there a rapid turnover of in the pathogenesis of nosocomial pneumonia?

<p>Fibronectin layer (A)</p> Signup and view all the answers

Which organism is nosocomial pneumonia usually associated with?

<p>Staphylococcus aureus (C)</p> Signup and view all the answers

What organism causes whooping cough?

<p>Bordetella pertussis (A)</p> Signup and view all the answers

Which of the following is described as a Gram-negative coccobacillus with humans as its reservoir?

<p>Bordetella pertussis (B)</p> Signup and view all the answers

What group usually spreads whooping cough infections to schools and daycare centers?

<p>Infected adults (A)</p> Signup and view all the answers

What does Pertussis have an affinity for?

<p>Ciliated bronchial epithelium (A)</p> Signup and view all the answers

What does Pertussis produce once it attaches?

<p>tracheal toxin (A)</p> Signup and view all the answers

Match each stage of pertussis with its definition

<h1>Catarrhal stage (1-2 weeks) = Persistent perfuse and mucoid rhinorrhea (runny nose); Sneezing, malaise, anorexia; Most communicable during this phase Paroxysmal stage = Persistent coughing: up to 50x’s/day for 2-4 weeks; Characteristic whooping sound: patients try to catch breath; Apnea can follow coughing especially in infants Convalescent stage = Frequency and severity of coughing and other symptoms gradually decrease</h1> Signup and view all the answers

What are some complications that can occur with a pertussis infection? (Select all that apply)

<p>Superinfection with Strep pneumonia (A), Convulsions (B), Subconjunctival and cerebral bleeding and anoxia (C)</p> Signup and view all the answers

Which of the following is described as a Gram-positive rod that is spore-forming?

<p>Bacillus anthracis (B)</p> Signup and view all the answers

Which organism has the following symptoms:

  • 1-5 days of nonspecific malaise, mild fever, nonproductive cough
  • Progressive respiratory distress and cyanosis
  • Rapid and massive spread to CNS and blood followed by death?

<p>Bacillus anthracis (C)</p> Signup and view all the answers

What is the treatment for anthrax?

<p>Penicillin (B)</p> Signup and view all the answers

Which of the following species is described:

  • Rod shaped bacillus
  • Acid-fast staining
  • Nonspore forming
  • Produces mycolic acid?

<p>Mycobacterium tuberculosis (C)</p> Signup and view all the answers

What is a primary TB complex called?

<p>Ghon's complex (A)</p> Signup and view all the answers

What do 90% of primary TB infections end as?

<p>Quiescent (silent) (B)</p> Signup and view all the answers

What can secondary TB infection lead to?

<p>Caseation necrosis caverns (A)</p> Signup and view all the answers

Where does secondary tuberculosis usually manifest?

<p>Apices of lungs (B)</p> Signup and view all the answers

Which of the following are treatments for tuberculosis (TB)? (Select all that apply)

<p>Triple therapy (Isoniazid, pyrazinamide, rifampicin) (A), Direct observed therapy (DOT) (C)</p> Signup and view all the answers

What family does influenza belong to?

<p>Orthomyxovirus (B)</p> Signup and view all the answers

What are the three major influenza serotypes?

<p>Type A (A), Type B (B), Type C (C)</p> Signup and view all the answers

What organism is the host of influenza?

<p>Humans (A)</p> Signup and view all the answers

Which organism is the reservoir of influenza?

<p>Aquatic birds (A)</p> Signup and view all the answers

What is a serious complication of influenza infection?

<p>Bacterial superinfection (B)</p> Signup and view all the answers

Which bacteria are the common cause of influenza superinfections? (Select all that apply)

<p>Streptococcus pneumoniae (A), Haemophilus influenzae (B), Staphylococcus aureus (C)</p> Signup and view all the answers

What does Respiratory Syncytial Virus (RSV) form in infected cells?

<p>Syncytia (B)</p> Signup and view all the answers

Which of the following are clinical signs of Respiratory Syncytial Virus (RSV)? (Select all that apply)

<p>Hyperexpansion (A), Hypoxia (B), Hypercapnia (C), Pulmonary collapse (D)</p> Signup and view all the answers

What is an atypical feature of Pneumocystis jiroveci?

<p>Has cholesterol in plasma membrane (A)</p> Signup and view all the answers

What radiographic appearance is indicative of Pneumocystis jiroveci?

<p>Honeycomb appearance in the lungs (B)</p> Signup and view all the answers

What does blastomycosis spread to?

<p>Skin (A), Bones (B), Genitourinary tract (C)</p> Signup and view all the answers

Where is histoplasmosis typically found?

<p>Soil contaminated with bat or bird droppings (A)</p> Signup and view all the answers

What is a short-term treatment for histoplasmosis?

<p>Amphotericin B (A)</p> Signup and view all the answers

What are HIV patients with Histoplasma treated with? (Select all that apply)

<p>Itraconazole (A), Ketoconazole (B)</p> Signup and view all the answers

What causes valley fever?

<p>Coccidioidomycosis (A)</p> Signup and view all the answers

Which organism is difficult to diagnose as it is hard to distinguish it from other molds and causes infection in immunocompromised patients?

<p>Aspergillus (B)</p> Signup and view all the answers

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