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Questions and Answers
Where is the major site for the synthesis of purine nucleotides?
Where is the major site for the synthesis of purine nucleotides?
- Heart
- Lungs
- Liver (correct)
- Kidney
What is the final degradation product of purine nucleotides?
What is the final degradation product of purine nucleotides?
- Creatinine
- Urea
- Uric acid (correct)
- Glucose
What is the role of Adenine phosphoribosyl transferase and hypoxanthine guanine phosphoribosyl transferase?
What is the role of Adenine phosphoribosyl transferase and hypoxanthine guanine phosphoribosyl transferase?
- Salvage free purines (correct)
- Excrete uric acid
- Degrade purine nucleotides
- Synthesize purine nucleotides
What can cause hyperuricemia?
What can cause hyperuricemia?
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What is gout?
What is gout?
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Study Notes
- Genetic information for protein synthesis is transcribed from DNA to mRNA.
- Translation turns the three-base code in mRNA into a 20-unit code for amino acid sequence.
- Purine nucleotides are synthesized in most tissues, with the major site being the liver.
- The de novo synthesis pathway for purine nucleotides has ten steps and occurs in the liver.
- The salvage pathway recycles purines formed by nucleotide degradation.
- Adenine phosphoribosyl transferase and hypoxanthine guanine phosphoribosyl transferase salvage free purines.
- Uric acid is the final degradation product of purine nucleotides.
- Uric acid is a normal component of urine, but hyperuricemia can occur.
- Hyperuricemia can result from increased production or decreased excretion of uric acid.
- Hyperuricemia can lead to gout, which can be primary or secondary.
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