Pulmonary Hypertension & ARDS

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Questions and Answers

What mean pulmonary artery pressure (PAP) is indicative of pulmonary hypertension at rest?

  • >30 mmHg
  • >20 mmHg
  • >25 mmHg (correct)
  • >35 mmHg

A patient presents with dyspnea on exertion, fatigue, and lower extremity edema. Which of the following physical exam findings would MOST strongly suggest pulmonary hypertension?

  • Carotid bruit
  • Diffuse wheezing
  • Accentuated pulmonary component of S2 (correct)
  • Left ventricular heave

Which of the following is a common symptom associated with pulmonary hypertension?

  • Pleuritic chest pain
  • Productive cough
  • Hemoptysis
  • Syncope (correct)

Which murmur is MOST suggestive of pulmonary hypertension on physical exam?

<p>Tricuspid regurgitation (B)</p> Signup and view all the answers

Cor pulmonale is best defined as:

<p>Enlargement of the right ventricle due to pulmonary hypertension (A)</p> Signup and view all the answers

According to the WHO classification, which of the following conditions is associated with pulmonary hypertension due to left heart disease (Group 2)?

<p>Left ventricular heart failure (B)</p> Signup and view all the answers

A patient with a long history of COPD is diagnosed with pulmonary hypertension. According to the WHO classification, which group does this patient MOST likely belong to?

<p>Group 3 (D)</p> Signup and view all the answers

Which of the following diagnostic tests is typically used in the initial evaluation of a patient with suspected pulmonary hypertension?

<p>Echocardiogram (A)</p> Signup and view all the answers

A patient with suspected pulmonary hypertension undergoes an ECG. Which of the following findings would be MOST suggestive of this condition?

<p>Right ventricular hypertrophy (A)</p> Signup and view all the answers

Which test is considered the gold standard for diagnosing pulmonary arterial hypertension (PAH)?

<p>Right heart catheterization (B)</p> Signup and view all the answers

During a right heart catheterization, a patient with suspected PAH is given a vasodilator. A significant drop in pulmonary artery pressure suggests?

<p>The patient is likely to respond to calcium channel blockers (A)</p> Signup and view all the answers

What is the rationale for avoiding pregnancy in patients with pulmonary arterial hypertension (PAH)?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following interventions is generally recommended for patients with pulmonary hypertension secondary to hypoxemia?

<p>Supplemental oxygen (B)</p> Signup and view all the answers

A patient is diagnosed with idiopathic pulmonary arterial hypertension (IPAH). According to treatment guidelines, which of the following medications might be considered, if the patient responds favorably to vasoreactivity testing?

<p>Calcium channel blockers (D)</p> Signup and view all the answers

A 35-year-old female presents with progressive dyspnea and fatigue. Echocardiography reveals a pulmonary artery pressure of 60 mmHg. Further workup identifies Raynaud's phenomenon and sclerodactyly. Which of the following is the MOST likely underlying cause of her pulmonary hypertension?

<p>Pulmonary hypertension associated with connective tissue disease (B)</p> Signup and view all the answers

A patient with known IPAH presents with worsening dyspnea and signs of right heart failure. Which of the following would be MOST appropriate initial management?

<p>Referral to a pulmonologist specializing in PAH (C)</p> Signup and view all the answers

In the diagnostic evaluation of pulmonary hypertension, a V/Q scan is MOST useful for identifying which of the following associated conditions?

<p>Chronic thromboembolic pulmonary hypertension (D)</p> Signup and view all the answers

What is the normal range for mean pulmonary artery pressure (PAP) at rest?

<p>8-20 mmHg (D)</p> Signup and view all the answers

According to the WHO classification of pulmonary hypertension, which group includes pulmonary hypertension due to congenital systemic-to-pulmonary shunts?

<p>Group 1 (B)</p> Signup and view all the answers

In a patient with pulmonary hypertension, which of the following physical exam findings is MOST suggestive of right ventricular dysfunction?

<p>Jugular venous distension (B)</p> Signup and view all the answers

A 45-year-old male with a history of intravenous drug use is diagnosed with pulmonary hypertension. Which of the following etiologies is MOST likely associated with his condition?

<p>HIV infection (C)</p> Signup and view all the answers

Which of the following is a common finding on chest X-ray in patients with pulmonary arterial hypertension (PAH)?

<p>Enlarged pulmonary arteries (A)</p> Signup and view all the answers

What is the primary goal of vasoreactivity testing during right heart catheterization in patients with pulmonary arterial hypertension (PAH)?

<p>To identify patients who may respond to calcium channel blockers (A)</p> Signup and view all the answers

According to the 2014 CHEST guidelines, what is a crucial step in managing patients with suspected pulmonary arterial hypertension (PAH) before initiating treatment?

<p>Confirm the diagnosis with right heart catheterization (B)</p> Signup and view all the answers

A 60-year-old male with a history of chronic venous thromboembolism presents with progressive dyspnea. Echocardiography reveals elevated pulmonary artery pressures. Which of the following is the MOST appropriate next step in management?

<p>Refer for pulmonary thromboendarterectomy (PTE) (A)</p> Signup and view all the answers

A patient is diagnosed with Group 1 pulmonary arterial hypertension (PAH) and demonstrates a positive response to vasoreactivity testing during right heart catheterization. Six months later, despite being on maximum doses of calcium channel blockers, the patient's symptoms have worsened. Which is the MOST appropriate next step in management?

<p>Add a phosphodiesterase-5 inhibitor or endothelin receptor antagonist to the calcium channel blocker (B)</p> Signup and view all the answers

You are evaluating a patient for possible pulmonary hypertension. The echocardiogram reveals right ventricular hypertrophy and an estimated PA systolic pressure of 55 mmHg. The patient has no history of lung disease or left heart dysfunction. Which of the following findings would be MOST suggestive of pulmonary veno-occlusive disease (PVOD) rather than idiopathic pulmonary arterial hypertension (IPAH)?

<p>Evidence of mosaic attenuation on high-resolution CT scan (B)</p> Signup and view all the answers

A patient with pulmonary hypertension and right heart failure is being considered for diuretic therapy. Which of the following is the MOST important consideration when initiating diuretics in this patient population?

<p>All of the above (D)</p> Signup and view all the answers

Which statement regarding exercise and pulmonary hypertension is MOST accurate?

<p>Regular aerobic exercise, with medical supervision, may be beneficial for patients with pulmonary hypertension. (D)</p> Signup and view all the answers

A patient presents with dyspnea on exertion. Which of the following additional symptoms would MOST likely lead to suspicion of pulmonary hypertension?

<p>Unexplained fatigue (B)</p> Signup and view all the answers

Which of the following physical exam findings is MOST commonly associated with pulmonary hypertension?

<p>Left parasternal lift (A)</p> Signup and view all the answers

What heart sound abnormality is MOST likely to be auscultated in a patient with pulmonary hypertension?

<p>Accentuated pulmonary component of S2 (D)</p> Signup and view all the answers

Which of the following findings is MOST indicative of right ventricular dysfunction in a patient with pulmonary hypertension?

<p>Jugular vein distension (B)</p> Signup and view all the answers

Which of the following best describes the pathophysiology of Cor Pulmonale?

<p>Enlargement of the right ventricle due to pulmonary hypertension (D)</p> Signup and view all the answers

A patient with chronic obstructive pulmonary disease (COPD) develops pulmonary hypertension. According to the WHO classification, this is classified as which group?

<p>Group 3: Pulmonary hypertension associated with lung diseases and/or hypoxemia (C)</p> Signup and view all the answers

According to the WHO classification, which of the following is included in Group 1 pulmonary arterial hypertension (PAH)?

<p>Idiopathic pulmonary arterial hypertension (IPAH) (B)</p> Signup and view all the answers

A patient has pulmonary hypertension secondary to mitral valve stenosis. According to the WHO classification, which group does this patient belong to?

<p>Group 2 (B)</p> Signup and view all the answers

A patient is suspected of having pulmonary hypertension. Which of the following diagnostic tests should be performed FIRST in the evaluation?

<p>Echocardiogram (B)</p> Signup and view all the answers

A patient with suspected pulmonary hypertension undergoes an ECG. Which ECG finding would raise suspicion for pulmonary hypertension?

<p>Right ventricular hypertrophy (A)</p> Signup and view all the answers

Which of the following diagnostic procedures provides the MOST definitive confirmation of pulmonary arterial hypertension (PAH)?

<p>Right heart catheterization (A)</p> Signup and view all the answers

During right heart catheterization for PAH, what hemodynamic parameter is assessed to determine vasoreactivity?

<p>Mean pulmonary artery pressure (mPAP) (A)</p> Signup and view all the answers

During a workup for pulmonary hypertension, when is a V/Q scan MOST appropriate?

<p>To rule out chronic thromboembolic pulmonary hypertension (CTEPH) (A)</p> Signup and view all the answers

According to the 2014 CHEST guidelines, what MUST be done before starting treatment for pulmonary arterial hypertension?

<p>Confirm the diagnosis of PAH with right heart catheterization (B)</p> Signup and view all the answers

A patient is diagnosed with Group 3 pulmonary hypertension. Which of the following is MOST likely to be part of the management strategy?

<p>Supplemental oxygen (C)</p> Signup and view all the answers

A patient with IPAH has a positive vasoreactivity test during right heart catheterization. Which medication class may be considered for long-term treatment?

<p>Calcium channel blockers (B)</p> Signup and view all the answers

Which of the following tests is MOST useful in differentiating between pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease (PVOD)?

<p>High-resolution CT scan of the chest (C)</p> Signup and view all the answers

In a patient with pulmonary hypertension and right heart failure, initiation of diuretic therapy requires careful consideration of:

<p>Monitoring for excessive diuresis, leading to decreased preload and reduced cardiac output. (A)</p> Signup and view all the answers

Which of the following statements is MOST accurate regarding exercise recommendations for patients with pulmonary hypertension?

<p>Regular aerobic exercise, with medical supervision, can be beneficial. (B)</p> Signup and view all the answers

A 30-year-old female with a history of Raynaud's phenomenon and sclerodactyly presents with new onset dyspnea on exertion. Which of the following underlying conditions is MOST likely the cause of her pulmonary hypertension?

<p>Systemic sclerosis (B)</p> Signup and view all the answers

A patient with pulmonary hypertension presents with signs of right heart failure. Which medication is CONTRAINDICATED if the patient does not respond to vasodilators during right heart catheterization?

<p>Calcium channel blockers (C)</p> Signup and view all the answers

Following the 2019 CHEST guidelines update for PAH treatment, which of the following actions is MOST strongly recommended?

<p>Immediate referral to a pulmonologist specializing in PAH. (B)</p> Signup and view all the answers

A patient with known Group 1 PAH presents with worsening dyspnea and signs of right heart failure despite being on tadalafil. Which is the MOST appropriate next step in management?

<p>Initiate dual therapy with ambrisentan. (D)</p> Signup and view all the answers

Which of the following disorders is LEAST likely to be associated with pulmonary hypertension?

<p>Hyperthyroidism. (B)</p> Signup and view all the answers

You are reviewing a chest X-ray of a patient suspected of having pulmonary hypertension. Which finding would strongly suggest pulmonary hypertension?

<p>Pruning of the peripheral pulmonary vessels with enlarged central pulmonary arteries (D)</p> Signup and view all the answers

A patient with pulmonary hypertension asks about the safety of pregnancy. What is the MOST accurate and appropriate counseling?

<p>Pregnancy is contraindicated due to high risk of maternal mortality (D)</p> Signup and view all the answers

Which medication is recommended for patients with idiopathic pulmonary hypertension, who demonstrate a positive response during right heart catheterization testing, meaning can tolerate the medication well long term??

<p>Calcium Channel Blockers (B)</p> Signup and view all the answers

A patient is diagnosed with pulmonary hypertension caused by chronic thromboembolic pulmonary hypertension (CTEPH), who is the patient mostly to be classified under according to the WHO?

<p>Group 4 (B)</p> Signup and view all the answers

What testing result diagnoses pulmonary hypertension and its subclasses?

<p>Right heart Catheter (A)</p> Signup and view all the answers

A patient presents with acute dyspnea and hypoxemia. According to the definition of ARDS, how quickly do these symptoms typically manifest following an inciting event?

<p>Hours to days (C)</p> Signup and view all the answers

Which of the following conditions is LEAST likely to be an inciting event for ARDS?

<p>Chronic hypertension (D)</p> Signup and view all the answers

The primary mechanism behind ARDS involves:

<p>Increased permeability of the alveolar-capillary barrier (A)</p> Signup and view all the answers

A chest radiograph of a patient with ARDS is most likely to show:

<p>Bilateral opacities (D)</p> Signup and view all the answers

According to the Berlin definition, ARDS is classified based on the PaO2/FiO2 ratio. A PaO2/FiO2 ratio of 150 mmHg indicates:

<p>Moderate ARDS (A)</p> Signup and view all the answers

Which of the following is a common manifestation of ARDS?

<p>Dyspnea (D)</p> Signup and view all the answers

The primary goal of ARDS treatment is:

<p>Treating the underlying condition and supporting breathing (B)</p> Signup and view all the answers

Which of the following ventilator strategies is a key component of the ARDSnet protocol?

<p>Low tidal volumes (C)</p> Signup and view all the answers

The exudative phase of diffuse alveolar damage in ARDS is characterized by:

<p>Hyaline membrane formation (C)</p> Signup and view all the answers

Which of the following is an important consideration when evaluating a patient with ARDS?

<p>All of the above (D)</p> Signup and view all the answers

Prone positioning is utilized in ARDS management to improve oxygenation primarily by:

<p>Reducing atelectasis (C)</p> Signup and view all the answers

Which I:E ratio is appropriate for ARDS ventilation strategy?

<p>1:3 (C)</p> Signup and view all the answers

Consider a patient with ARDS secondary to sepsis. Initial ventilator settings include a tidal volume of 6 mL/kg, FiO2 of 60%, and PEEP of 10 cm H2O. The PaO2 is 65 mmHg. According to ARDSnet protocols, what is the MOST appropriate next step in ventilator management?

<p>Increase PEEP (B)</p> Signup and view all the answers

A patient with ARDS is being mechanically ventilated. Despite optimal ventilator settings, including appropriate tidal volume and PEEP, the patient's PaO2 remains critically low. All of the following interventions may be considered EXCEPT:

<p>Administration of high-dose corticosteroids (A)</p> Signup and view all the answers

A patient with ARDS is on mechanical ventilation. The plateau pressure is trending upwards despite stable tidal volumes. Which of the following is LEAST likely to be contributing to the rising plateau pressure?

<p>Improved lung compliance (C)</p> Signup and view all the answers

Which of the following best describes the early phase of diffuse alveolar damage in ARDS?

<p>Exudative (A)</p> Signup and view all the answers

A patient is diagnosed with ARDS following a septic episode. According to diagnostic criteria, within what timeframe should the onset of respiratory symptoms typically occur?

<p>Within 1 week (D)</p> Signup and view all the answers

What is the underlying cause of ARDS?

<p>Fluid leaked from the smallest blood vessels in the lungs into the tiny air sacs (D)</p> Signup and view all the answers

A patient with ARDS has a PaO2/FiO2 ratio of 150 mmHg while on a PEEP of 5 cm H2O. How would this patient's ARDS be classified according to the Berlin criteria?

<p>Moderate (A)</p> Signup and view all the answers

Which of the following is an expected finding on a chest X-ray of a patient with ARDS?

<p>Bilateral opacities (B)</p> Signup and view all the answers

Which of the following is considered a key component of the ARDSnet protocol for mechanical ventilation?

<p>Low tidal volumes (B)</p> Signup and view all the answers

A patient with ARDS is being mechanically ventilated. What is the primary goal of this intervention?

<p>Improve oxygenation (C)</p> Signup and view all the answers

A patient with ARDS is on mechanical ventilation with a PEEP of 10 cm H2O. What is the primary purpose of using PEEP in this setting?

<p>Prevent alveolar collapse (A)</p> Signup and view all the answers

Which of the following is the most common underlying mechanism that leads to ARDS??

<p>Increased alveolar-capillary permeability (D)</p> Signup and view all the answers

Which of the following is NOT typically considered an inciting event for ARDS?

<p>Pneumothorax (B)</p> Signup and view all the answers

A patient with ARDS is being mechanically ventilated. The physician is considering prone positioning. What is the primary physiological rationale for this intervention?

<p>To improve V/Q matching (D)</p> Signup and view all the answers

While adhering to ARDSnet protocols, a patient's PaO2 remains inadequate despite optimal FiO2 and PEEP settings. What pharmacological intervention might be considered as an adjunct to improve oxygenation?

<p>Neuromuscular blockade (D)</p> Signup and view all the answers

Which of the following Initial ventilator settings would be most ideal in a patient diagnosed with ARDS?

<p>Tidal volume of 4-6 mL/kg, Increase PEEP rather than FiO2, Consider increasing sedation to promote synchrony with ventilator (B)</p> Signup and view all the answers

A patient with severe ARDS is being mechanically ventilated. Despite optimizing tidal volume, PEEP, and FiO2, the patient's PaO2 remains critically low, and plateau pressures are elevated. Which of the following interventions is LEAST likely to improve oxygenation and lung mechanics in this scenario?

<p>Administering a high dose of intravenous corticosteroids (A)</p> Signup and view all the answers

A 55-year-old male is intubated for ARDS secondary to aspiration pneumonia. His initial vent settings are TV 6ml/kg, RR 20, FiO2 60%, and PEEP 10. His ABG shows pH 7.20, PaCO2 60, PaO2 60. The physician increases the respiratory rate to 28, but the pH only improves to 7.24 and the PaCO2 remains elevated at 58. The PaO2 also remains unchanged at 60. What would be the MOST appropriate next step according to ARDSnet protocols?

<p>Permissive hypercapnia (B)</p> Signup and view all the answers

A 55-year-old woman presents with progressive dyspnea on exertion, fatigue, and syncope. Exam reveals loud P2, a systolic murmur of tricuspid regurgitation, and right ventricular heave. What is the most likely diagnosis?

<p>Pulmonary hypertension (D)</p> Signup and view all the answers

Which of the following is the gold standard test for diagnosing pulmonary arterial hypertension (PAH)?

<p>Right heart catheterization (A)</p> Signup and view all the answers

A patient with idiopathic PAH undergoes a vasoreactivity test during right heart catheterization. He has a positive response. What is the next best treatment step?

<p>Calcium channel blocker (nifedipine) (B)</p> Signup and view all the answers

A patient with pulmonary hypertension due to left-sided heart failure (PH Group 2) is best managed with:

<p>Diuretics and afterload reduction (C)</p> Signup and view all the answers

Which of the following pulmonary hypertension groups is most associated with chronic thromboembolic disease (CTEPH)?

<p>Group 4 (Thromboembolic disease) (B)</p> Signup and view all the answers

A patient with pulmonary hypertension and signs of right ventricular failure should receive which initial therapy?

<p>IV loop diuretics and oxygen (C)</p> Signup and view all the answers

A patient with pulmonary hypertension and chronic hypoxemia due to COPD should receive:

<p>Long-term supplemental oxygen (B)</p> Signup and view all the answers

Which of the following is a contraindication to calcium channel blockers in PAH?

<p>Negative vasoreactivity test on right heart catheterization (C)</p> Signup and view all the answers

A patient with severe ARDS is placed on mechanical ventilation. What is the recommended tidal volume setting to minimize ventilator-induced lung injury?

<p>4-6 mL/kg of ideal body weight (C)</p> Signup and view all the answers

Which of the following is the most effective strategy to improve oxygenation in ARDS while avoiding ventilator-induced lung injury?

<p>Increase PEEP (Positive End-Expiratory Pressure) (B)</p> Signup and view all the answers

A patient with ARDS is placed in prone positioning. What is the primary benefit of this intervention?

<p>Improves V/Q matching and oxygenation (B)</p> Signup and view all the answers

Which of the following is the best initial step in managing ARDS?

<p>Initiate lung-protective mechanical ventilation (B)</p> Signup and view all the answers

Which of the following is a hallmark feature of ARDS?

<p>PaO2/FiO2 ratio ≤ 300 mmHg (B)</p> Signup and view all the answers

A 45-year-old woman with systemic sclerosis presents with progressive dyspnea and exertional fatigue. Echocardiogram shows right ventricular hypertrophy and an estimated pulmonary artery pressure of 50 mmHg. Right heart catheterization confirms PAH with a mean pulmonary artery pressure (mPAP) of 30 mmHg at rest. What is the most likely classification of this patient's pulmonary hypertension?

<p>Group 1: Pulmonary Arterial Hypertension (PAH) (D)</p> Signup and view all the answers

A patient with severe idiopathic pulmonary arterial hypertension (IPAH) is placed on epoprostenol (IV prostacyclin therapy). What is the primary mechanism of this medication?

<p>Directly vasodilates pulmonary arteries and inhibits platelet aggregation (C)</p> Signup and view all the answers

Which diagnostic test is most useful in differentiating pulmonary hypertension (PH) due to left heart disease (Group 2) from PAH (Group 1)?

<p>Right heart catheterization with pulmonary capillary wedge pressure (PCWP) (C)</p> Signup and view all the answers

A patient with chronic thromboembolic pulmonary hypertension (CTEPH) is not a candidate for pulmonary thromboendarterectomy. What is the next best pharmacologic therapy?

<p>Riociguat (Soluble Guanylate Cyclase Stimulator) (B)</p> Signup and view all the answers

A patient with severe pulmonary arterial hypertension (PAH) and right ventricular failure develops worsening hypotension and shock. Which of the following interventions is contraindicated?

<p>IV beta-blockers for rate control (C)</p> Signup and view all the answers

Which of the following is a key pathophysiologic feature of ARDS?

<p>Increased capillary permeability leading to alveolar flooding (D)</p> Signup and view all the answers

A patient with ARDS is on mechanical ventilation with the following settings: • Tidal volume: 6 mL/kg IBW • FiO2: 70% • PEEP: 10 cm H₂O His PaO2 remains at 55 mmHg. What is the next best step?

<p>Increase PEEP (A)</p> Signup and view all the answers

A patient with ARDS is placed in prone positioning. What is the primary reason for this intervention?

<p>Improves ventilation-perfusion (V/Q) matching and oxygenation (B)</p> Signup and view all the answers

Which of the following patients is at highest risk for developing ARDS?

<p>A 55-year-old septic patient with multi-organ dysfunction (C)</p> Signup and view all the answers

Which of the following ventilator settings is most important to prevent ventilator-induced lung injury (VILI) in ARDS?

<p>Low tidal volume (4-6 mL/kg IBW) (A)</p> Signup and view all the answers

A patient with ARDS is found to have worsening hypoxemia despite maximal ventilator support. Which of the following is the best next step?

<p>Initiate extracorporeal membrane oxygenation (ECMO) (D)</p> Signup and view all the answers

A patient with chronic thromboembolic pulmonary hypertension (CTEPH) is being evaluated for definitive therapy. Which of the following interventions offers the best chance for cure?

<p>Pulmonary thromboendarterectomy (PTE) (A)</p> Signup and view all the answers

Which of the following is the most common presenting symptom in patients with pulmonary hypertension?

<p>Dyspnea on exertion (B)</p> Signup and view all the answers

A patient with pulmonary arterial hypertension (PAH) due to connective tissue disease (scleroderma) is started on initial therapy. Which class of medications is the first-line treatment for most PAH patients without a positive vasoreactivity test?

<p>Endothelin receptor antagonists (ERA) (e.g., ambrisentan, bosentan) (C)</p> Signup and view all the answers

Which diagnostic test should be performed in a patient with suspected pulmonary hypertension due to chronic thromboembolism (Group 4 PH)?

<p>V/Q scan (B)</p> Signup and view all the answers

Which of the following findings on echocardiogram is most suggestive of pulmonary hypertension?

<p>Right ventricular hypertrophy and dilation (C)</p> Signup and view all the answers

Which of the following is most characteristic of ARDS-related hypoxemia?

<p>Refractory hypoxemia despite high FiO2 (A)</p> Signup and view all the answers

A 50-year-old patient with sepsis-induced ARDS is on mechanical ventilation. Which ventilator setting most reduces barotrauma risk?

<p>Tidal volume of 4-6 mL/kg IBW (A)</p> Signup and view all the answers

A patient with ARDS is on mechanical ventilation with a PaO2 of 52 mmHg despite FiO2 of 60% and PEEP of 10 cm H2O. What is the next best step?

<p>Increase PEEP to improve oxygenation (B)</p> Signup and view all the answers

Which of the following interventions has been shown to improve survival in severe ARDS?

<p>Prone positioning (B)</p> Signup and view all the answers

Which of the following arterial blood gas (ABG) findings is most consistent with early ARDS?

<p>Hypoxemia with respiratory alkalosis (C)</p> Signup and view all the answers

A patient with severe ARDS is placed on extracorporeal membrane oxygenation (ECMO). Which of the following is the most common indication for ECMO in ARDS?

<p>Refractory hypoxemia despite maximal ventilator settings (A)</p> Signup and view all the answers

Which of the following ventilation strategies is most appropriate for ARDS patients with persistent hypercapnia?

<p>Allow permissive hypercapnia with lung-protective ventilation (C)</p> Signup and view all the answers

Flashcards

Pulmonary hypertension definition

Mean pulmonary artery pressure (PAP) greater than 25 mmHg at rest.

Symptoms of pulmonary hypertension

Dyspnea with exertion or at rest (advanced disease), fatigue, weakness, angina, syncope, signs of right-sided heart failure.

Physical exam findings in pulmonary hypertension

Left parasternal lift, accentuated pulmonary component of S2, pansystolic murmur of tricuspid regurgitation, diastolic murmur of pulmonary insufficiency, right ventricular S3/S4.

Cor Pulmonale

Enlargement of the right ventricle caused by pulmonary hypertension leading to right-sided heart failure and dyspnea.

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WHO Group 2 Pulmonary Hypertension

Pulmonary hypertension due to left ventricular heart failure or left ventricular heart disease.

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WHO Group 3 Pulmonary Hypertension

Chronic obstructive pulmonary disease, interstitial lung disease, and sleep-disordered breathing.

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WHO Group 4 Pulmonary Hypertension

Pulmonary hypertension due to chronic thrombotic or embolic disease.

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Initial diagnostic steps of pulmonary hypertension

History and physical, ECG, CXR, and echocardiogram.

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Further diagnostic Pulmonary HTN testing

Pulmonary function tests and ABGs, sleep study, and V/Q scan or CT.

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Management of Group 2-4 Pulmonary HTN

Diuretics, supplemental O2, and treatment of the underlying disorder.

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Initial evaluation of PAH

Tests include blood work and HIV tests and abdominal ultrasound.

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Exercise capacity evaluation in PAH

Six-minute walk test.

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Gold Standard

You need a right-heart catheterization to diagnose Group 1: Pulmonary Arterial Hypertension (PAH)

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iPAH vasoreactivity

iPAH (idiopathic pulmonary arterial hypertension) will usually have a positive vasoreactivity.

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2014 CHEST PAH treatment guidelines

Make sure the patient really has PAH (rather than another form of pulmonary hypertension Group 2-4) and has had a right heart catheterization including vasoreactivity testing if indicated.

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Supportive care for Pulmonary HTN

Diuretics for right ventricular failure, and giving oxygen if hypoxemic.

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Things patients with PAH shouldn't do

Avoid pregnancy; hemodynamic changes are dangerous. Vaccines, and sometimes anticoagulation with warfarin are important.

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Pulmonologist expertise

The disease severity and the patient's symptoms determine treatment.

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Pulmonary Hypertension

Elevated blood pressure in the pulmonary arteries. Mean pulmonary artery pressure >25 mmHg.

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Echocardiogram in PH

A non-invasive test used to assess heart structure and function; used to estimate pulmonary artery pressure.

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RVH in Pulmonary HTN

Right ventricular hypertrophy due to pulmonary hypertension that can lead to right sided heart failure.

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Pulmonary Arterial Hypertension (PAH)

Group 1 pulmonary hypertension; can be idiopathic, familial, or associated with other conditions.

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Pulmonary Angiography for Pulmonary HTN

Further PAH diagnostic testing to further evaluate for thromboembolic disease.

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Polysomnography in Pulmonary HTN

Used to evaluate for sleep apnea, can cause or exacerbate pulmonary hypertension.

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CTD Serologies

To evaluate the presence of connective tissue diseases that may be associated with pulmonary hypertension.

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ARDS Definition

Acute dyspnea and hypoxemia occurring within hours to days of an inciting event.

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Common ARDS Inciting Events

Septic shock, trauma, burns, aspiration, drug overdose and fat embolisms (long bone fractures).

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ARDS Pathophysiology

Increased permeability of the alveolar-capillary barrier leading to fluid leakage into the alveoli.

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ARDS Lung Injury

Diffuse alveolar damage and lung capillary endothelial injury.

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ARDS Chest X-ray Findings

Bilateral opacities on chest radiograph not fully explained by effusions.

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Mild ARDS

PaO2/FiO2 ≤ 300 mmHg

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Moderate ARDS

PaO2/FiO2 ≤ 200 mmHg

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Severe ARDS

PaO2/FIO2 ≤ 100 mmHg

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ARDS Manifestations

Dyspnea, hypoxemia, and potential need for intubation and mechanical ventilation.

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ARDS Treatment

Supportive care, managing hypoxemia, and treating the underlying condition.

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ARDS Treatment Considerations

Evaluation of respiratory, cardiac, and renal status, ventilator settings, and lung sounds.

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Prone Positioning in ARDS

Turning patient prone to improve oxygenation.

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ARDS Ventilator Protocol

ARDSNet protocol (NIH – NHLBI).

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ARDS Ventilator Settings

Lower tidal volumes and increase PEEP rather than FiO2.

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Common ARDS Causes

Shock, trauma, burns, aspiration, drug overdose, DIC, fat emboli.

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ARDS: Mechanical Cause

Increased fluid leaks from lung capillaries to the air sacs.

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ARDS: X-Ray Findings

Bilateral opacities on chest X-ray, not due to heart failure.

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ARDS - Clinical features

Dyspnea, Hypoxemia, potential intubation and ventilation.

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ARDS - Primary treatment

Address hypoxemia & underlying cause.

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Monitoring ARDS

Ventilator settings, ABGs, volume status, lung sounds.

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PaO2/FiO2 ratio

The ratio of PaO2 to FiO2. Used to determine ARDS severity.

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Signs of pulmonary hypertension

A systolic murmur, loud P2, and right ventricular heave suggests increased pulmonary artery pressure.

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Gold standard test for PAH

Right heart catheterization is the definitive diagnostic tool, showing a mean pulmonary artery pressure > 25 mmHg.

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PAH vasoreactivity treatment

Calcium channel blockers (CCBs) are effective in PAH patients exhibiting a positive response during the vasoreactivity test.

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PH due to left heart failure management

Treat the underlying heart failure with diuretics, ACE inhibitors, and beta-blockers to manage pulmonary hypertension secondary to left heart failure.

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Right ventricular failure 1st line treatment

IV loop diuretics and oxygen support are key interventions, aiming to manage fluid overload and improve oxygenation.

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COPD & Pulmonary Hypertension treatment

Addresses hypoxemia to prevent further pulmonary vasoconstriction and disease progression.

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CCB contraindication in PAH

Negative vasoreactivity makes you NOT a candidate for CCBs

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Key indicator for ARDS

ARDS is hallmarked by a PaO2/FiO2 ratio of ≤ 300 mmHg, indicating a significant impairment in oxygen exchange.

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Tidal volume with ARDS

Low tidal volume ventilation reduces the risk of barotrauma by minimizing overdistension of the alveoli.

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Prone positions for ARDS

Prone positioning redistributes lung perfusion, improving V/Q matching and thereby increasing oxygenation.

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Study Notes

Pulmonary Hypertension (PH) Overview

  • Pulmonary hypertension is suspected with a loud P2 heart sound, right ventricular heave, and tricuspid regurgitation murmur.
  • The gold standard for diagnosing pulmonary arterial hypertension (PAH) is right heart catheterization, with a mean pulmonary artery pressure (mPAP) > 25 mmHg.
  • Dyspnea on exertion is the most common presenting symptom with syncope occurring later in the disease.
  • Echocardiogram findings suggestive of PH include right ventricular hypertrophy and dilation, along with an elevated pulmonary artery pressure (PAP).

Pulmonary Arterial Hypertension (PAH) Treatment

  • Positive vasoreactivity during right heart catheterization indicates calcium channel blockers (CCBs) can be used.
  • If vasoreactivity test is negative, avoid CCBs and use other PAH drugs.
  • First-line medications for PAH patients without positive vasoreactivity include endothelin receptor antagonists (ERA) like ambrisentan or bosentan, PDE-5 inhibitors, and prostacyclins
  • Supportive care for right ventricular failure involves diuretics and oxygen. Also avoid beta-blockers.
  • In severe PAH with right ventricular failure, avoid beta-blockers due to their potential to reduce cardiac output.
  • Epoprostenol is a prostacyclin that directly vasodilates pulmonary arteries and inhibits platelet aggregation.

Pulmonary Hypertension Classification and Associated Conditions

  • PH due to left-sided heart failure (Group 2) is best managed with diuretics and afterload reduction and management of underlying conditions such as heart failure.
  • Pulmonary hypertension (PH) Group 3 associated with COPD is treated with long-term supplemental oxygen.
  • Chronic thromboembolic pulmonary hypertension (CTEPH) is classified as Group 4 PH.
  • For CTEPH, if the patient is not a candidate for pulmonary thromboendarterectomy, riociguat (Soluble Guanylate Cyclase Stimulator) is recommended, as it is the only FDA-approved drug.
  • A V/Q scan is the gold standard for diagnosing CTEPH.
  • Systemic sclerosis (connective tissue disease or scleroderma) is linked to Group 1: Pulmonary Arterial Hypertension (PAH).

Acute Respiratory Distress Syndrome (ARDS) Overview

  • A PaO2/FiO2 ratio ≤ 300 is indicative of ARDS.
  • Sepsis is the number one risk factor for ARDS.
  • ARDS is characterized by refractory hypoxemia (shunting, no response to O2).
  • A key feature of ARDS is increased capillary permeability that leads to alveolar flooding, causing non-cardiogenic pulmonary edema.

ARDS Management and Ventilation Strategies

  • Early intubation with low tidal volume ventilation is an important initial step in managing ARDS.
  • Low tidal volume ventilation (4-6 mL/kg of ideal body weight) is used to prevent barotrauma.
  • Increasing PEEP is preferred over increasing FiO2 to improve oxygenation in ARDS.
  • Prone positioning enhances oxygenation in ARDS by improving V/Q matching.
  • ARDS patients often need increased sedation to promote synchrony with the ventilator
  • Early ARDS is characterized by hypoxemia and respiratory alkalosis (hyperventilation response).
  • In ARDS, permissive hypercapnia is allowed to avoid barotrauma.
  • Optimal ventilator settings to prevent ventilator-induced lung injury (VILI) include low tidal volume (4-6 mL/kg IBW).

ARDS and Extracorporeal Membrane Oxygenation (ECMO)

  • ECMO is considered for refractory ARDS when hypoxemia persists despite maximal ventilator support.

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