Podcast
Questions and Answers
What mean pulmonary artery pressure (PAP) is indicative of pulmonary hypertension at rest?
What mean pulmonary artery pressure (PAP) is indicative of pulmonary hypertension at rest?
- >30 mmHg
- >20 mmHg
- >25 mmHg (correct)
- >35 mmHg
A patient presents with dyspnea on exertion, fatigue, and lower extremity edema. Which of the following physical exam findings would MOST strongly suggest pulmonary hypertension?
A patient presents with dyspnea on exertion, fatigue, and lower extremity edema. Which of the following physical exam findings would MOST strongly suggest pulmonary hypertension?
- Carotid bruit
- Diffuse wheezing
- Accentuated pulmonary component of S2 (correct)
- Left ventricular heave
Which of the following is a common symptom associated with pulmonary hypertension?
Which of the following is a common symptom associated with pulmonary hypertension?
- Pleuritic chest pain
- Productive cough
- Hemoptysis
- Syncope (correct)
Which murmur is MOST suggestive of pulmonary hypertension on physical exam?
Which murmur is MOST suggestive of pulmonary hypertension on physical exam?
Cor pulmonale is best defined as:
Cor pulmonale is best defined as:
According to the WHO classification, which of the following conditions is associated with pulmonary hypertension due to left heart disease (Group 2)?
According to the WHO classification, which of the following conditions is associated with pulmonary hypertension due to left heart disease (Group 2)?
A patient with a long history of COPD is diagnosed with pulmonary hypertension. According to the WHO classification, which group does this patient MOST likely belong to?
A patient with a long history of COPD is diagnosed with pulmonary hypertension. According to the WHO classification, which group does this patient MOST likely belong to?
Which of the following diagnostic tests is typically used in the initial evaluation of a patient with suspected pulmonary hypertension?
Which of the following diagnostic tests is typically used in the initial evaluation of a patient with suspected pulmonary hypertension?
A patient with suspected pulmonary hypertension undergoes an ECG. Which of the following findings would be MOST suggestive of this condition?
A patient with suspected pulmonary hypertension undergoes an ECG. Which of the following findings would be MOST suggestive of this condition?
Which test is considered the gold standard for diagnosing pulmonary arterial hypertension (PAH)?
Which test is considered the gold standard for diagnosing pulmonary arterial hypertension (PAH)?
During a right heart catheterization, a patient with suspected PAH is given a vasodilator. A significant drop in pulmonary artery pressure suggests?
During a right heart catheterization, a patient with suspected PAH is given a vasodilator. A significant drop in pulmonary artery pressure suggests?
What is the rationale for avoiding pregnancy in patients with pulmonary arterial hypertension (PAH)?
What is the rationale for avoiding pregnancy in patients with pulmonary arterial hypertension (PAH)?
Which of the following interventions is generally recommended for patients with pulmonary hypertension secondary to hypoxemia?
Which of the following interventions is generally recommended for patients with pulmonary hypertension secondary to hypoxemia?
A patient is diagnosed with idiopathic pulmonary arterial hypertension (IPAH). According to treatment guidelines, which of the following medications might be considered, if the patient responds favorably to vasoreactivity testing?
A patient is diagnosed with idiopathic pulmonary arterial hypertension (IPAH). According to treatment guidelines, which of the following medications might be considered, if the patient responds favorably to vasoreactivity testing?
A 35-year-old female presents with progressive dyspnea and fatigue. Echocardiography reveals a pulmonary artery pressure of 60 mmHg. Further workup identifies Raynaud's phenomenon and sclerodactyly. Which of the following is the MOST likely underlying cause of her pulmonary hypertension?
A 35-year-old female presents with progressive dyspnea and fatigue. Echocardiography reveals a pulmonary artery pressure of 60 mmHg. Further workup identifies Raynaud's phenomenon and sclerodactyly. Which of the following is the MOST likely underlying cause of her pulmonary hypertension?
A patient with known IPAH presents with worsening dyspnea and signs of right heart failure. Which of the following would be MOST appropriate initial management?
A patient with known IPAH presents with worsening dyspnea and signs of right heart failure. Which of the following would be MOST appropriate initial management?
In the diagnostic evaluation of pulmonary hypertension, a V/Q scan is MOST useful for identifying which of the following associated conditions?
In the diagnostic evaluation of pulmonary hypertension, a V/Q scan is MOST useful for identifying which of the following associated conditions?
What is the normal range for mean pulmonary artery pressure (PAP) at rest?
What is the normal range for mean pulmonary artery pressure (PAP) at rest?
According to the WHO classification of pulmonary hypertension, which group includes pulmonary hypertension due to congenital systemic-to-pulmonary shunts?
According to the WHO classification of pulmonary hypertension, which group includes pulmonary hypertension due to congenital systemic-to-pulmonary shunts?
In a patient with pulmonary hypertension, which of the following physical exam findings is MOST suggestive of right ventricular dysfunction?
In a patient with pulmonary hypertension, which of the following physical exam findings is MOST suggestive of right ventricular dysfunction?
A 45-year-old male with a history of intravenous drug use is diagnosed with pulmonary hypertension. Which of the following etiologies is MOST likely associated with his condition?
A 45-year-old male with a history of intravenous drug use is diagnosed with pulmonary hypertension. Which of the following etiologies is MOST likely associated with his condition?
Which of the following is a common finding on chest X-ray in patients with pulmonary arterial hypertension (PAH)?
Which of the following is a common finding on chest X-ray in patients with pulmonary arterial hypertension (PAH)?
What is the primary goal of vasoreactivity testing during right heart catheterization in patients with pulmonary arterial hypertension (PAH)?
What is the primary goal of vasoreactivity testing during right heart catheterization in patients with pulmonary arterial hypertension (PAH)?
According to the 2014 CHEST guidelines, what is a crucial step in managing patients with suspected pulmonary arterial hypertension (PAH) before initiating treatment?
According to the 2014 CHEST guidelines, what is a crucial step in managing patients with suspected pulmonary arterial hypertension (PAH) before initiating treatment?
A 60-year-old male with a history of chronic venous thromboembolism presents with progressive dyspnea. Echocardiography reveals elevated pulmonary artery pressures. Which of the following is the MOST appropriate next step in management?
A 60-year-old male with a history of chronic venous thromboembolism presents with progressive dyspnea. Echocardiography reveals elevated pulmonary artery pressures. Which of the following is the MOST appropriate next step in management?
A patient is diagnosed with Group 1 pulmonary arterial hypertension (PAH) and demonstrates a positive response to vasoreactivity testing during right heart catheterization. Six months later, despite being on maximum doses of calcium channel blockers, the patient's symptoms have worsened. Which is the MOST appropriate next step in management?
A patient is diagnosed with Group 1 pulmonary arterial hypertension (PAH) and demonstrates a positive response to vasoreactivity testing during right heart catheterization. Six months later, despite being on maximum doses of calcium channel blockers, the patient's symptoms have worsened. Which is the MOST appropriate next step in management?
You are evaluating a patient for possible pulmonary hypertension. The echocardiogram reveals right ventricular hypertrophy and an estimated PA systolic pressure of 55 mmHg. The patient has no history of lung disease or left heart dysfunction. Which of the following findings would be MOST suggestive of pulmonary veno-occlusive disease (PVOD) rather than idiopathic pulmonary arterial hypertension (IPAH)?
You are evaluating a patient for possible pulmonary hypertension. The echocardiogram reveals right ventricular hypertrophy and an estimated PA systolic pressure of 55 mmHg. The patient has no history of lung disease or left heart dysfunction. Which of the following findings would be MOST suggestive of pulmonary veno-occlusive disease (PVOD) rather than idiopathic pulmonary arterial hypertension (IPAH)?
A patient with pulmonary hypertension and right heart failure is being considered for diuretic therapy. Which of the following is the MOST important consideration when initiating diuretics in this patient population?
A patient with pulmonary hypertension and right heart failure is being considered for diuretic therapy. Which of the following is the MOST important consideration when initiating diuretics in this patient population?
Which statement regarding exercise and pulmonary hypertension is MOST accurate?
Which statement regarding exercise and pulmonary hypertension is MOST accurate?
A patient presents with dyspnea on exertion. Which of the following additional symptoms would MOST likely lead to suspicion of pulmonary hypertension?
A patient presents with dyspnea on exertion. Which of the following additional symptoms would MOST likely lead to suspicion of pulmonary hypertension?
Which of the following physical exam findings is MOST commonly associated with pulmonary hypertension?
Which of the following physical exam findings is MOST commonly associated with pulmonary hypertension?
What heart sound abnormality is MOST likely to be auscultated in a patient with pulmonary hypertension?
What heart sound abnormality is MOST likely to be auscultated in a patient with pulmonary hypertension?
Which of the following findings is MOST indicative of right ventricular dysfunction in a patient with pulmonary hypertension?
Which of the following findings is MOST indicative of right ventricular dysfunction in a patient with pulmonary hypertension?
Which of the following best describes the pathophysiology of Cor Pulmonale?
Which of the following best describes the pathophysiology of Cor Pulmonale?
A patient with chronic obstructive pulmonary disease (COPD) develops pulmonary hypertension. According to the WHO classification, this is classified as which group?
A patient with chronic obstructive pulmonary disease (COPD) develops pulmonary hypertension. According to the WHO classification, this is classified as which group?
According to the WHO classification, which of the following is included in Group 1 pulmonary arterial hypertension (PAH)?
According to the WHO classification, which of the following is included in Group 1 pulmonary arterial hypertension (PAH)?
A patient has pulmonary hypertension secondary to mitral valve stenosis. According to the WHO classification, which group does this patient belong to?
A patient has pulmonary hypertension secondary to mitral valve stenosis. According to the WHO classification, which group does this patient belong to?
A patient is suspected of having pulmonary hypertension. Which of the following diagnostic tests should be performed FIRST in the evaluation?
A patient is suspected of having pulmonary hypertension. Which of the following diagnostic tests should be performed FIRST in the evaluation?
A patient with suspected pulmonary hypertension undergoes an ECG. Which ECG finding would raise suspicion for pulmonary hypertension?
A patient with suspected pulmonary hypertension undergoes an ECG. Which ECG finding would raise suspicion for pulmonary hypertension?
Which of the following diagnostic procedures provides the MOST definitive confirmation of pulmonary arterial hypertension (PAH)?
Which of the following diagnostic procedures provides the MOST definitive confirmation of pulmonary arterial hypertension (PAH)?
During right heart catheterization for PAH, what hemodynamic parameter is assessed to determine vasoreactivity?
During right heart catheterization for PAH, what hemodynamic parameter is assessed to determine vasoreactivity?
During a workup for pulmonary hypertension, when is a V/Q scan MOST appropriate?
During a workup for pulmonary hypertension, when is a V/Q scan MOST appropriate?
According to the 2014 CHEST guidelines, what MUST be done before starting treatment for pulmonary arterial hypertension?
According to the 2014 CHEST guidelines, what MUST be done before starting treatment for pulmonary arterial hypertension?
A patient is diagnosed with Group 3 pulmonary hypertension. Which of the following is MOST likely to be part of the management strategy?
A patient is diagnosed with Group 3 pulmonary hypertension. Which of the following is MOST likely to be part of the management strategy?
A patient with IPAH has a positive vasoreactivity test during right heart catheterization. Which medication class may be considered for long-term treatment?
A patient with IPAH has a positive vasoreactivity test during right heart catheterization. Which medication class may be considered for long-term treatment?
Which of the following tests is MOST useful in differentiating between pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease (PVOD)?
Which of the following tests is MOST useful in differentiating between pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease (PVOD)?
In a patient with pulmonary hypertension and right heart failure, initiation of diuretic therapy requires careful consideration of:
In a patient with pulmonary hypertension and right heart failure, initiation of diuretic therapy requires careful consideration of:
Which of the following statements is MOST accurate regarding exercise recommendations for patients with pulmonary hypertension?
Which of the following statements is MOST accurate regarding exercise recommendations for patients with pulmonary hypertension?
A 30-year-old female with a history of Raynaud's phenomenon and sclerodactyly presents with new onset dyspnea on exertion. Which of the following underlying conditions is MOST likely the cause of her pulmonary hypertension?
A 30-year-old female with a history of Raynaud's phenomenon and sclerodactyly presents with new onset dyspnea on exertion. Which of the following underlying conditions is MOST likely the cause of her pulmonary hypertension?
A patient with pulmonary hypertension presents with signs of right heart failure. Which medication is CONTRAINDICATED if the patient does not respond to vasodilators during right heart catheterization?
A patient with pulmonary hypertension presents with signs of right heart failure. Which medication is CONTRAINDICATED if the patient does not respond to vasodilators during right heart catheterization?
Following the 2019 CHEST guidelines update for PAH treatment, which of the following actions is MOST strongly recommended?
Following the 2019 CHEST guidelines update for PAH treatment, which of the following actions is MOST strongly recommended?
A patient with known Group 1 PAH presents with worsening dyspnea and signs of right heart failure despite being on tadalafil. Which is the MOST appropriate next step in management?
A patient with known Group 1 PAH presents with worsening dyspnea and signs of right heart failure despite being on tadalafil. Which is the MOST appropriate next step in management?
Which of the following disorders is LEAST likely to be associated with pulmonary hypertension?
Which of the following disorders is LEAST likely to be associated with pulmonary hypertension?
You are reviewing a chest X-ray of a patient suspected of having pulmonary hypertension. Which finding would strongly suggest pulmonary hypertension?
You are reviewing a chest X-ray of a patient suspected of having pulmonary hypertension. Which finding would strongly suggest pulmonary hypertension?
A patient with pulmonary hypertension asks about the safety of pregnancy. What is the MOST accurate and appropriate counseling?
A patient with pulmonary hypertension asks about the safety of pregnancy. What is the MOST accurate and appropriate counseling?
Which medication is recommended for patients with idiopathic pulmonary hypertension, who demonstrate a positive response during right heart catheterization testing, meaning can tolerate the medication well long term??
Which medication is recommended for patients with idiopathic pulmonary hypertension, who demonstrate a positive response during right heart catheterization testing, meaning can tolerate the medication well long term??
A patient is diagnosed with pulmonary hypertension caused by chronic thromboembolic pulmonary hypertension (CTEPH), who is the patient mostly to be classified under according to the WHO?
A patient is diagnosed with pulmonary hypertension caused by chronic thromboembolic pulmonary hypertension (CTEPH), who is the patient mostly to be classified under according to the WHO?
What testing result diagnoses pulmonary hypertension and its subclasses?
What testing result diagnoses pulmonary hypertension and its subclasses?
A patient presents with acute dyspnea and hypoxemia. According to the definition of ARDS, how quickly do these symptoms typically manifest following an inciting event?
A patient presents with acute dyspnea and hypoxemia. According to the definition of ARDS, how quickly do these symptoms typically manifest following an inciting event?
Which of the following conditions is LEAST likely to be an inciting event for ARDS?
Which of the following conditions is LEAST likely to be an inciting event for ARDS?
The primary mechanism behind ARDS involves:
The primary mechanism behind ARDS involves:
A chest radiograph of a patient with ARDS is most likely to show:
A chest radiograph of a patient with ARDS is most likely to show:
According to the Berlin definition, ARDS is classified based on the PaO2/FiO2 ratio. A PaO2/FiO2 ratio of 150 mmHg indicates:
According to the Berlin definition, ARDS is classified based on the PaO2/FiO2 ratio. A PaO2/FiO2 ratio of 150 mmHg indicates:
Which of the following is a common manifestation of ARDS?
Which of the following is a common manifestation of ARDS?
The primary goal of ARDS treatment is:
The primary goal of ARDS treatment is:
Which of the following ventilator strategies is a key component of the ARDSnet protocol?
Which of the following ventilator strategies is a key component of the ARDSnet protocol?
The exudative phase of diffuse alveolar damage in ARDS is characterized by:
The exudative phase of diffuse alveolar damage in ARDS is characterized by:
Which of the following is an important consideration when evaluating a patient with ARDS?
Which of the following is an important consideration when evaluating a patient with ARDS?
Prone positioning is utilized in ARDS management to improve oxygenation primarily by:
Prone positioning is utilized in ARDS management to improve oxygenation primarily by:
Which I:E ratio is appropriate for ARDS ventilation strategy?
Which I:E ratio is appropriate for ARDS ventilation strategy?
Consider a patient with ARDS secondary to sepsis. Initial ventilator settings include a tidal volume of 6 mL/kg, FiO2 of 60%, and PEEP of 10 cm H2O. The PaO2 is 65 mmHg. According to ARDSnet protocols, what is the MOST appropriate next step in ventilator management?
Consider a patient with ARDS secondary to sepsis. Initial ventilator settings include a tidal volume of 6 mL/kg, FiO2 of 60%, and PEEP of 10 cm H2O. The PaO2 is 65 mmHg. According to ARDSnet protocols, what is the MOST appropriate next step in ventilator management?
A patient with ARDS is being mechanically ventilated. Despite optimal ventilator settings, including appropriate tidal volume and PEEP, the patient's PaO2 remains critically low. All of the following interventions may be considered EXCEPT:
A patient with ARDS is being mechanically ventilated. Despite optimal ventilator settings, including appropriate tidal volume and PEEP, the patient's PaO2 remains critically low. All of the following interventions may be considered EXCEPT:
A patient with ARDS is on mechanical ventilation. The plateau pressure is trending upwards despite stable tidal volumes. Which of the following is LEAST likely to be contributing to the rising plateau pressure?
A patient with ARDS is on mechanical ventilation. The plateau pressure is trending upwards despite stable tidal volumes. Which of the following is LEAST likely to be contributing to the rising plateau pressure?
Which of the following best describes the early phase of diffuse alveolar damage in ARDS?
Which of the following best describes the early phase of diffuse alveolar damage in ARDS?
A patient is diagnosed with ARDS following a septic episode. According to diagnostic criteria, within what timeframe should the onset of respiratory symptoms typically occur?
A patient is diagnosed with ARDS following a septic episode. According to diagnostic criteria, within what timeframe should the onset of respiratory symptoms typically occur?
What is the underlying cause of ARDS?
What is the underlying cause of ARDS?
A patient with ARDS has a PaO2/FiO2 ratio of 150 mmHg while on a PEEP of 5 cm H2O. How would this patient's ARDS be classified according to the Berlin criteria?
A patient with ARDS has a PaO2/FiO2 ratio of 150 mmHg while on a PEEP of 5 cm H2O. How would this patient's ARDS be classified according to the Berlin criteria?
Which of the following is an expected finding on a chest X-ray of a patient with ARDS?
Which of the following is an expected finding on a chest X-ray of a patient with ARDS?
Which of the following is considered a key component of the ARDSnet protocol for mechanical ventilation?
Which of the following is considered a key component of the ARDSnet protocol for mechanical ventilation?
A patient with ARDS is being mechanically ventilated. What is the primary goal of this intervention?
A patient with ARDS is being mechanically ventilated. What is the primary goal of this intervention?
A patient with ARDS is on mechanical ventilation with a PEEP of 10 cm H2O. What is the primary purpose of using PEEP in this setting?
A patient with ARDS is on mechanical ventilation with a PEEP of 10 cm H2O. What is the primary purpose of using PEEP in this setting?
Which of the following is the most common underlying mechanism that leads to ARDS??
Which of the following is the most common underlying mechanism that leads to ARDS??
Which of the following is NOT typically considered an inciting event for ARDS?
Which of the following is NOT typically considered an inciting event for ARDS?
A patient with ARDS is being mechanically ventilated. The physician is considering prone positioning. What is the primary physiological rationale for this intervention?
A patient with ARDS is being mechanically ventilated. The physician is considering prone positioning. What is the primary physiological rationale for this intervention?
While adhering to ARDSnet protocols, a patient's PaO2 remains inadequate despite optimal FiO2 and PEEP settings. What pharmacological intervention might be considered as an adjunct to improve oxygenation?
While adhering to ARDSnet protocols, a patient's PaO2 remains inadequate despite optimal FiO2 and PEEP settings. What pharmacological intervention might be considered as an adjunct to improve oxygenation?
Which of the following Initial ventilator settings would be most ideal in a patient diagnosed with ARDS?
Which of the following Initial ventilator settings would be most ideal in a patient diagnosed with ARDS?
A patient with severe ARDS is being mechanically ventilated. Despite optimizing tidal volume, PEEP, and FiO2, the patient's PaO2 remains critically low, and plateau pressures are elevated. Which of the following interventions is LEAST likely to improve oxygenation and lung mechanics in this scenario?
A patient with severe ARDS is being mechanically ventilated. Despite optimizing tidal volume, PEEP, and FiO2, the patient's PaO2 remains critically low, and plateau pressures are elevated. Which of the following interventions is LEAST likely to improve oxygenation and lung mechanics in this scenario?
A 55-year-old male is intubated for ARDS secondary to aspiration pneumonia. His initial vent settings are TV 6ml/kg, RR 20, FiO2 60%, and PEEP 10. His ABG shows pH 7.20, PaCO2 60, PaO2 60. The physician increases the respiratory rate to 28, but the pH only improves to 7.24 and the PaCO2 remains elevated at 58. The PaO2 also remains unchanged at 60. What would be the MOST appropriate next step according to ARDSnet protocols?
A 55-year-old male is intubated for ARDS secondary to aspiration pneumonia. His initial vent settings are TV 6ml/kg, RR 20, FiO2 60%, and PEEP 10. His ABG shows pH 7.20, PaCO2 60, PaO2 60. The physician increases the respiratory rate to 28, but the pH only improves to 7.24 and the PaCO2 remains elevated at 58. The PaO2 also remains unchanged at 60. What would be the MOST appropriate next step according to ARDSnet protocols?
A 55-year-old woman presents with progressive dyspnea on exertion, fatigue, and syncope. Exam reveals loud P2, a systolic murmur of tricuspid regurgitation, and right ventricular heave. What is the most likely diagnosis?
A 55-year-old woman presents with progressive dyspnea on exertion, fatigue, and syncope. Exam reveals loud P2, a systolic murmur of tricuspid regurgitation, and right ventricular heave. What is the most likely diagnosis?
Which of the following is the gold standard test for diagnosing pulmonary arterial hypertension (PAH)?
Which of the following is the gold standard test for diagnosing pulmonary arterial hypertension (PAH)?
A patient with idiopathic PAH undergoes a vasoreactivity test during right heart catheterization. He has a positive response. What is the next best treatment step?
A patient with idiopathic PAH undergoes a vasoreactivity test during right heart catheterization. He has a positive response. What is the next best treatment step?
A patient with pulmonary hypertension due to left-sided heart failure (PH Group 2) is best managed with:
A patient with pulmonary hypertension due to left-sided heart failure (PH Group 2) is best managed with:
Which of the following pulmonary hypertension groups is most associated with chronic thromboembolic disease (CTEPH)?
Which of the following pulmonary hypertension groups is most associated with chronic thromboembolic disease (CTEPH)?
A patient with pulmonary hypertension and signs of right ventricular failure should receive which initial therapy?
A patient with pulmonary hypertension and signs of right ventricular failure should receive which initial therapy?
A patient with pulmonary hypertension and chronic hypoxemia due to COPD should receive:
A patient with pulmonary hypertension and chronic hypoxemia due to COPD should receive:
Which of the following is a contraindication to calcium channel blockers in PAH?
Which of the following is a contraindication to calcium channel blockers in PAH?
A patient with severe ARDS is placed on mechanical ventilation. What is the recommended tidal volume setting to minimize ventilator-induced lung injury?
A patient with severe ARDS is placed on mechanical ventilation. What is the recommended tidal volume setting to minimize ventilator-induced lung injury?
Which of the following is the most effective strategy to improve oxygenation in ARDS while avoiding ventilator-induced lung injury?
Which of the following is the most effective strategy to improve oxygenation in ARDS while avoiding ventilator-induced lung injury?
A patient with ARDS is placed in prone positioning. What is the primary benefit of this intervention?
A patient with ARDS is placed in prone positioning. What is the primary benefit of this intervention?
Which of the following is the best initial step in managing ARDS?
Which of the following is the best initial step in managing ARDS?
Which of the following is a hallmark feature of ARDS?
Which of the following is a hallmark feature of ARDS?
A 45-year-old woman with systemic sclerosis presents with progressive dyspnea and exertional fatigue. Echocardiogram shows right ventricular hypertrophy and an estimated pulmonary artery pressure of 50 mmHg. Right heart catheterization confirms PAH with a mean pulmonary artery pressure (mPAP) of 30 mmHg at rest. What is the most likely classification of this patient's pulmonary hypertension?
A 45-year-old woman with systemic sclerosis presents with progressive dyspnea and exertional fatigue. Echocardiogram shows right ventricular hypertrophy and an estimated pulmonary artery pressure of 50 mmHg. Right heart catheterization confirms PAH with a mean pulmonary artery pressure (mPAP) of 30 mmHg at rest. What is the most likely classification of this patient's pulmonary hypertension?
A patient with severe idiopathic pulmonary arterial hypertension (IPAH) is placed on epoprostenol (IV prostacyclin therapy). What is the primary mechanism of this medication?
A patient with severe idiopathic pulmonary arterial hypertension (IPAH) is placed on epoprostenol (IV prostacyclin therapy). What is the primary mechanism of this medication?
Which diagnostic test is most useful in differentiating pulmonary hypertension (PH) due to left heart disease (Group 2) from PAH (Group 1)?
Which diagnostic test is most useful in differentiating pulmonary hypertension (PH) due to left heart disease (Group 2) from PAH (Group 1)?
A patient with chronic thromboembolic pulmonary hypertension (CTEPH) is not a candidate for pulmonary thromboendarterectomy. What is the next best pharmacologic therapy?
A patient with chronic thromboembolic pulmonary hypertension (CTEPH) is not a candidate for pulmonary thromboendarterectomy. What is the next best pharmacologic therapy?
A patient with severe pulmonary arterial hypertension (PAH) and right ventricular failure develops worsening hypotension and shock. Which of the following interventions is contraindicated?
A patient with severe pulmonary arterial hypertension (PAH) and right ventricular failure develops worsening hypotension and shock. Which of the following interventions is contraindicated?
Which of the following is a key pathophysiologic feature of ARDS?
Which of the following is a key pathophysiologic feature of ARDS?
A patient with ARDS is on mechanical ventilation with the following settings:
• Tidal volume: 6 mL/kg IBW
• FiO2: 70%
• PEEP: 10 cm H₂O
His PaO2 remains at 55 mmHg. What is the next best step?
A patient with ARDS is on mechanical ventilation with the following settings: • Tidal volume: 6 mL/kg IBW • FiO2: 70% • PEEP: 10 cm H₂O His PaO2 remains at 55 mmHg. What is the next best step?
A patient with ARDS is placed in prone positioning. What is the primary reason for this intervention?
A patient with ARDS is placed in prone positioning. What is the primary reason for this intervention?
Which of the following patients is at highest risk for developing ARDS?
Which of the following patients is at highest risk for developing ARDS?
Which of the following ventilator settings is most important to prevent ventilator-induced lung injury (VILI) in ARDS?
Which of the following ventilator settings is most important to prevent ventilator-induced lung injury (VILI) in ARDS?
A patient with ARDS is found to have worsening hypoxemia despite maximal ventilator support. Which of the following is the best next step?
A patient with ARDS is found to have worsening hypoxemia despite maximal ventilator support. Which of the following is the best next step?
A patient with chronic thromboembolic pulmonary hypertension (CTEPH) is being evaluated for definitive therapy. Which of the following interventions offers the best chance for cure?
A patient with chronic thromboembolic pulmonary hypertension (CTEPH) is being evaluated for definitive therapy. Which of the following interventions offers the best chance for cure?
Which of the following is the most common presenting symptom in patients with pulmonary hypertension?
Which of the following is the most common presenting symptom in patients with pulmonary hypertension?
A patient with pulmonary arterial hypertension (PAH) due to connective tissue disease (scleroderma) is started on initial therapy. Which class of medications is the first-line treatment for most PAH patients without a positive vasoreactivity test?
A patient with pulmonary arterial hypertension (PAH) due to connective tissue disease (scleroderma) is started on initial therapy. Which class of medications is the first-line treatment for most PAH patients without a positive vasoreactivity test?
Which diagnostic test should be performed in a patient with suspected pulmonary hypertension due to chronic thromboembolism (Group 4 PH)?
Which diagnostic test should be performed in a patient with suspected pulmonary hypertension due to chronic thromboembolism (Group 4 PH)?
Which of the following findings on echocardiogram is most suggestive of pulmonary hypertension?
Which of the following findings on echocardiogram is most suggestive of pulmonary hypertension?
Which of the following is most characteristic of ARDS-related hypoxemia?
Which of the following is most characteristic of ARDS-related hypoxemia?
A 50-year-old patient with sepsis-induced ARDS is on mechanical ventilation. Which ventilator setting most reduces barotrauma risk?
A 50-year-old patient with sepsis-induced ARDS is on mechanical ventilation. Which ventilator setting most reduces barotrauma risk?
A patient with ARDS is on mechanical ventilation with a PaO2 of 52 mmHg despite FiO2 of 60% and PEEP of 10 cm H2O. What is the next best step?
A patient with ARDS is on mechanical ventilation with a PaO2 of 52 mmHg despite FiO2 of 60% and PEEP of 10 cm H2O. What is the next best step?
Which of the following interventions has been shown to improve survival in severe ARDS?
Which of the following interventions has been shown to improve survival in severe ARDS?
Which of the following arterial blood gas (ABG) findings is most consistent with early ARDS?
Which of the following arterial blood gas (ABG) findings is most consistent with early ARDS?
A patient with severe ARDS is placed on extracorporeal membrane oxygenation (ECMO). Which of the following is the most common indication for ECMO in ARDS?
A patient with severe ARDS is placed on extracorporeal membrane oxygenation (ECMO). Which of the following is the most common indication for ECMO in ARDS?
Which of the following ventilation strategies is most appropriate for ARDS patients with persistent hypercapnia?
Which of the following ventilation strategies is most appropriate for ARDS patients with persistent hypercapnia?
Flashcards
Pulmonary hypertension definition
Pulmonary hypertension definition
Mean pulmonary artery pressure (PAP) greater than 25 mmHg at rest.
Symptoms of pulmonary hypertension
Symptoms of pulmonary hypertension
Dyspnea with exertion or at rest (advanced disease), fatigue, weakness, angina, syncope, signs of right-sided heart failure.
Physical exam findings in pulmonary hypertension
Physical exam findings in pulmonary hypertension
Left parasternal lift, accentuated pulmonary component of S2, pansystolic murmur of tricuspid regurgitation, diastolic murmur of pulmonary insufficiency, right ventricular S3/S4.
Cor Pulmonale
Cor Pulmonale
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WHO Group 2 Pulmonary Hypertension
WHO Group 2 Pulmonary Hypertension
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WHO Group 3 Pulmonary Hypertension
WHO Group 3 Pulmonary Hypertension
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WHO Group 4 Pulmonary Hypertension
WHO Group 4 Pulmonary Hypertension
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Initial diagnostic steps of pulmonary hypertension
Initial diagnostic steps of pulmonary hypertension
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Further diagnostic Pulmonary HTN testing
Further diagnostic Pulmonary HTN testing
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Management of Group 2-4 Pulmonary HTN
Management of Group 2-4 Pulmonary HTN
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Initial evaluation of PAH
Initial evaluation of PAH
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Exercise capacity evaluation in PAH
Exercise capacity evaluation in PAH
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Gold Standard
Gold Standard
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iPAH vasoreactivity
iPAH vasoreactivity
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2014 CHEST PAH treatment guidelines
2014 CHEST PAH treatment guidelines
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Supportive care for Pulmonary HTN
Supportive care for Pulmonary HTN
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Things patients with PAH shouldn't do
Things patients with PAH shouldn't do
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Pulmonologist expertise
Pulmonologist expertise
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Pulmonary Hypertension
Pulmonary Hypertension
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Echocardiogram in PH
Echocardiogram in PH
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RVH in Pulmonary HTN
RVH in Pulmonary HTN
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Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension (PAH)
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Pulmonary Angiography for Pulmonary HTN
Pulmonary Angiography for Pulmonary HTN
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Polysomnography in Pulmonary HTN
Polysomnography in Pulmonary HTN
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CTD Serologies
CTD Serologies
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ARDS Definition
ARDS Definition
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Common ARDS Inciting Events
Common ARDS Inciting Events
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ARDS Pathophysiology
ARDS Pathophysiology
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ARDS Lung Injury
ARDS Lung Injury
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ARDS Chest X-ray Findings
ARDS Chest X-ray Findings
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Mild ARDS
Mild ARDS
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Moderate ARDS
Moderate ARDS
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Severe ARDS
Severe ARDS
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ARDS Manifestations
ARDS Manifestations
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ARDS Treatment
ARDS Treatment
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ARDS Treatment Considerations
ARDS Treatment Considerations
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Prone Positioning in ARDS
Prone Positioning in ARDS
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ARDS Ventilator Protocol
ARDS Ventilator Protocol
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ARDS Ventilator Settings
ARDS Ventilator Settings
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Common ARDS Causes
Common ARDS Causes
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ARDS: Mechanical Cause
ARDS: Mechanical Cause
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ARDS: X-Ray Findings
ARDS: X-Ray Findings
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ARDS - Clinical features
ARDS - Clinical features
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ARDS - Primary treatment
ARDS - Primary treatment
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Monitoring ARDS
Monitoring ARDS
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PaO2/FiO2 ratio
PaO2/FiO2 ratio
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Signs of pulmonary hypertension
Signs of pulmonary hypertension
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Gold standard test for PAH
Gold standard test for PAH
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PAH vasoreactivity treatment
PAH vasoreactivity treatment
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PH due to left heart failure management
PH due to left heart failure management
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Right ventricular failure 1st line treatment
Right ventricular failure 1st line treatment
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COPD & Pulmonary Hypertension treatment
COPD & Pulmonary Hypertension treatment
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CCB contraindication in PAH
CCB contraindication in PAH
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Key indicator for ARDS
Key indicator for ARDS
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Tidal volume with ARDS
Tidal volume with ARDS
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Prone positions for ARDS
Prone positions for ARDS
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Study Notes
Pulmonary Hypertension (PH) Overview
- Pulmonary hypertension is suspected with a loud P2 heart sound, right ventricular heave, and tricuspid regurgitation murmur.
- The gold standard for diagnosing pulmonary arterial hypertension (PAH) is right heart catheterization, with a mean pulmonary artery pressure (mPAP) > 25 mmHg.
- Dyspnea on exertion is the most common presenting symptom with syncope occurring later in the disease.
- Echocardiogram findings suggestive of PH include right ventricular hypertrophy and dilation, along with an elevated pulmonary artery pressure (PAP).
Pulmonary Arterial Hypertension (PAH) Treatment
- Positive vasoreactivity during right heart catheterization indicates calcium channel blockers (CCBs) can be used.
- If vasoreactivity test is negative, avoid CCBs and use other PAH drugs.
- First-line medications for PAH patients without positive vasoreactivity include endothelin receptor antagonists (ERA) like ambrisentan or bosentan, PDE-5 inhibitors, and prostacyclins
- Supportive care for right ventricular failure involves diuretics and oxygen. Also avoid beta-blockers.
- In severe PAH with right ventricular failure, avoid beta-blockers due to their potential to reduce cardiac output.
- Epoprostenol is a prostacyclin that directly vasodilates pulmonary arteries and inhibits platelet aggregation.
Pulmonary Hypertension Classification and Associated Conditions
- PH due to left-sided heart failure (Group 2) is best managed with diuretics and afterload reduction and management of underlying conditions such as heart failure.
- Pulmonary hypertension (PH) Group 3 associated with COPD is treated with long-term supplemental oxygen.
- Chronic thromboembolic pulmonary hypertension (CTEPH) is classified as Group 4 PH.
- For CTEPH, if the patient is not a candidate for pulmonary thromboendarterectomy, riociguat (Soluble Guanylate Cyclase Stimulator) is recommended, as it is the only FDA-approved drug.
- A V/Q scan is the gold standard for diagnosing CTEPH.
- Systemic sclerosis (connective tissue disease or scleroderma) is linked to Group 1: Pulmonary Arterial Hypertension (PAH).
Acute Respiratory Distress Syndrome (ARDS) Overview
- A PaO2/FiO2 ratio ≤ 300 is indicative of ARDS.
- Sepsis is the number one risk factor for ARDS.
- ARDS is characterized by refractory hypoxemia (shunting, no response to O2).
- A key feature of ARDS is increased capillary permeability that leads to alveolar flooding, causing non-cardiogenic pulmonary edema.
ARDS Management and Ventilation Strategies
- Early intubation with low tidal volume ventilation is an important initial step in managing ARDS.
- Low tidal volume ventilation (4-6 mL/kg of ideal body weight) is used to prevent barotrauma.
- Increasing PEEP is preferred over increasing FiO2 to improve oxygenation in ARDS.
- Prone positioning enhances oxygenation in ARDS by improving V/Q matching.
- ARDS patients often need increased sedation to promote synchrony with the ventilator
- Early ARDS is characterized by hypoxemia and respiratory alkalosis (hyperventilation response).
- In ARDS, permissive hypercapnia is allowed to avoid barotrauma.
- Optimal ventilator settings to prevent ventilator-induced lung injury (VILI) include low tidal volume (4-6 mL/kg IBW).
ARDS and Extracorporeal Membrane Oxygenation (ECMO)
- ECMO is considered for refractory ARDS when hypoxemia persists despite maximal ventilator support.
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