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Questions and Answers
The primary lesion of pulmonary tuberculosis in childhood is known as a gumla focus.
The primary lesion of pulmonary tuberculosis in childhood is known as a gumla focus.
False (B)
In emphysema, the destruction of alveolar walls leads to increased air space size distal to the terminal bronchiole.
In emphysema, the destruction of alveolar walls leads to increased air space size distal to the terminal bronchiole.
True (A)
Proteases and antiproteases contribute to the pathogenesis of emphysema by producing protease.
Proteases and antiproteases contribute to the pathogenesis of emphysema by producing protease.
False (B)
Asthma is characterized by paroxysmal constriction of the bronchial airways and occlusion by thin mucous plugs.
Asthma is characterized by paroxysmal constriction of the bronchial airways and occlusion by thin mucous plugs.
Chronic bronchitis involves persistent cough with sputum production.
Chronic bronchitis involves persistent cough with sputum production.
Non-small cell carcinoma accounts for 70-80% of epithelial lung tumours.
Non-small cell carcinoma accounts for 70-80% of epithelial lung tumours.
Squamous cell carcinoma of the lung primarily arises in the peripheral bronchi.
Squamous cell carcinoma of the lung primarily arises in the peripheral bronchi.
Cigarette smoking is a recognized cause of primary bronchial carcinoma.
Cigarette smoking is a recognized cause of primary bronchial carcinoma.
Small cell carcinoma accounts for 10-15% of malignant lung tumours.
Small cell carcinoma accounts for 10-15% of malignant lung tumours.
Histamine release in allergic asthma results from the activation of mast cells and basophils.
Histamine release in allergic asthma results from the activation of mast cells and basophils.
Peripheral tumours of the lung are typically adenocarcinomas.
Peripheral tumours of the lung are typically adenocarcinomas.
Finger clubbing is a common metastatic effect of bronchial carcinoma.
Finger clubbing is a common metastatic effect of bronchial carcinoma.
Secondary lung tumours usually manifest as a solitary mass within the lung.
Secondary lung tumours usually manifest as a solitary mass within the lung.
A benign tumor cannot metastasize but can still be lethal, such as in the central nervous system.
A benign tumor cannot metastasize but can still be lethal, such as in the central nervous system.
Malignant tumors are incapable of invading and spreading from their original site.
Malignant tumors are incapable of invading and spreading from their original site.
Carcinomas primarily spread through blood.
Carcinomas primarily spread through blood.
Differentiation refers to how closely cancer resembles its original site of origin.
Differentiation refers to how closely cancer resembles its original site of origin.
Epithelium refers to tissues that line external or internal surfaces of the body.
Epithelium refers to tissues that line external or internal surfaces of the body.
Anaplasia describes cells with a uniform appearance.
Anaplasia describes cells with a uniform appearance.
Oncogenes suppress tumor growth and prevent cancer formation.
Oncogenes suppress tumor growth and prevent cancer formation.
Germ cell tumors may affect reproductive systems such as testes and ovaries.
Germ cell tumors may affect reproductive systems such as testes and ovaries.
The primary cause of infections in the upper respiratory tract is typically bacterial.
The primary cause of infections in the upper respiratory tract is typically bacterial.
The lower respiratory tract can be affected by secondary bacterial infections following a viral infection.
The lower respiratory tract can be affected by secondary bacterial infections following a viral infection.
Acute laryngitis can be caused by Streptococcus Pyogenes.
Acute laryngitis can be caused by Streptococcus Pyogenes.
Pneumonia is a result of infection in the bronchial tree rather than in the alveolar spaces.
Pneumonia is a result of infection in the bronchial tree rather than in the alveolar spaces.
Lobar pneumonia inflammation starts in the bronchus and spreads to adjacent alveolar spaces.
Lobar pneumonia inflammation starts in the bronchus and spreads to adjacent alveolar spaces.
The defence mechanisms of the respiratory organs include nasal hairs and the cough reflex.
The defence mechanisms of the respiratory organs include nasal hairs and the cough reflex.
Viral sore throat can be caused by the Adenovirus.
Viral sore throat can be caused by the Adenovirus.
Bronchopneumonia is characterized by interstitial pneumonia with initial atypical inflammation.
Bronchopneumonia is characterized by interstitial pneumonia with initial atypical inflammation.
Which of the following is a common causative agent of community-acquired pneumonia?
Which of the following is a common causative agent of community-acquired pneumonia?
Nosocomial pneumonia is defined as pneumonia acquired outside of a hospital setting.
Nosocomial pneumonia is defined as pneumonia acquired outside of a hospital setting.
Name two gram-negative rod bacteria that are commonly associated with nosocomial pneumonia.
Name two gram-negative rod bacteria that are commonly associated with nosocomial pneumonia.
Pneumococcal pneumonia often presents with an abrupt onset including symptoms like high fever, chills, and ______ chest pain.
Pneumococcal pneumonia often presents with an abrupt onset including symptoms like high fever, chills, and ______ chest pain.
Match the type of pneumonia with its associated characteristics or causative agents:
Match the type of pneumonia with its associated characteristics or causative agents:
Which of the following is typically associated with upper respiratory tract infections?
Which of the following is typically associated with upper respiratory tract infections?
The lower respiratory tract includes the nose, larynx, and trachea.
The lower respiratory tract includes the nose, larynx, and trachea.
Name two defense mechanisms of the respiratory tract that can be impaired leading to pneumonia.
Name two defense mechanisms of the respiratory tract that can be impaired leading to pneumonia.
Common cold is most frequently caused by different serotypes of _________.
Common cold is most frequently caused by different serotypes of _________.
Match the type of pneumonia with its description:
Match the type of pneumonia with its description:
Which of these is NOT a typical cause of lower respiratory tract sepsis?
Which of these is NOT a typical cause of lower respiratory tract sepsis?
Secondary bacterial infections can occur following a viral infection in the respiratory tract.
Secondary bacterial infections can occur following a viral infection in the respiratory tract.
What is the primary host reaction in pneumonia, leading to consolidation?
What is the primary host reaction in pneumonia, leading to consolidation?
Acute laryngitis or epiglottitis can be caused by _ _ _ _ _ _ _ _ _ _ _ _ _ _ influenza type B or _ _ _ _ _ _ _ _ _ _ _ _ _ pyogenes.
Acute laryngitis or epiglottitis can be caused by _ _ _ _ _ _ _ _ _ _ _ _ _ _ influenza type B or _ _ _ _ _ _ _ _ _ _ _ _ _ pyogenes.
Which defense mechanism is impaired by cigarette smoke, hot gases, corrosives, and viruses?
Which defense mechanism is impaired by cigarette smoke, hot gases, corrosives, and viruses?
Lobar pneumonia typically heals with fibrosis.
Lobar pneumonia typically heals with fibrosis.
Name one bacterial genus commonly associated with bronchopneumonia.
Name one bacterial genus commonly associated with bronchopneumonia.
Influenza mainly involves the _________ respiratory tract and is accompanied by fever, lassitude, and depression.
Influenza mainly involves the _________ respiratory tract and is accompanied by fever, lassitude, and depression.
What is a crucial step in managing pneumonia according to the text?
What is a crucial step in managing pneumonia according to the text?
Upper respiratory tract bacterial infections are common in healthy individuals in developed countries.
Upper respiratory tract bacterial infections are common in healthy individuals in developed countries.
Which type of hypersensitivity reaction is classically associated with atopic asthma?
Which type of hypersensitivity reaction is classically associated with atopic asthma?
Squamous cell carcinoma of the lung typically originates in peripheral lung tissue.
Squamous cell carcinoma of the lung typically originates in peripheral lung tissue.
Name two environmental antigens that can trigger atopic asthma.
Name two environmental antigens that can trigger atopic asthma.
Bronchial carcinoma is strongly associated with smoking, particularly the use of ______.
Bronchial carcinoma is strongly associated with smoking, particularly the use of ______.
Match the following lung cancer types with their characteristics:
Match the following lung cancer types with their characteristics:
What is the most common type of primary malignant lung tumour?
What is the most common type of primary malignant lung tumour?
The incidence of bronchial carcinoma is currently higher in females than in males in the US.
The incidence of bronchial carcinoma is currently higher in females than in males in the US.
List two common sites of blood metastasis for bronchial carcinoma.
List two common sites of blood metastasis for bronchial carcinoma.
Neuroendocrine carcinomas of the lung can produce hormones such as ACTH, ADH, and ______.
Neuroendocrine carcinomas of the lung can produce hormones such as ACTH, ADH, and ______.
Which of the following is NOT considered a non-metastatic systemic effect of bronchial carcinoma?
Which of the following is NOT considered a non-metastatic systemic effect of bronchial carcinoma?
Which conditions are encompassed by the clinical term Chronic Obstructive Pulmonary Disease (COPD)?
Which conditions are encompassed by the clinical term Chronic Obstructive Pulmonary Disease (COPD)?
Chronic bronchitis is defined by a persistent cough with sputum production for at least six months in one year.
Chronic bronchitis is defined by a persistent cough with sputum production for at least six months in one year.
What is the primary characteristic of emphysema related to the lung's air spaces?
What is the primary characteristic of emphysema related to the lung's air spaces?
In emphysema, the destruction of alveolar walls is primarily due to an imbalance between increased ______ and decreased antiproteases.
In emphysema, the destruction of alveolar walls is primarily due to an imbalance between increased ______ and decreased antiproteases.
Match the type of asthma with its precipitating mechanism:
Match the type of asthma with its precipitating mechanism:
Which of the following is a typical symptom of asthma?
Which of the following is a typical symptom of asthma?
Emphysema is more commonly observed in women between 50-80 years old.
Emphysema is more commonly observed in women between 50-80 years old.
Name one factor that predisposes individuals to chronic bronchitis by interfering with ciliary action.
Name one factor that predisposes individuals to chronic bronchitis by interfering with ciliary action.
Status asthmaticus, an unremitting attack of asthma, can be potentially ______.
Status asthmaticus, an unremitting attack of asthma, can be potentially ______.
In the pathogenesis of emphysema, what is the role of neutrophils and macrophages in smokers?
In the pathogenesis of emphysema, what is the role of neutrophils and macrophages in smokers?
Flashcards
Upper Respiratory Tract Infection
Upper Respiratory Tract Infection
Infection that affects the nose, sinuses, larynx, trachea, and main bronchi. Usually caused by a virus.
Lower Respiratory Tract Infection
Lower Respiratory Tract Infection
Infection that affects the bronchi, lungs, and terminal bronchi. Often more serious, caused by bacteria, viruses, irritants, fungi, or atypical pathogens.
Bronchopneumonia
Bronchopneumonia
An inflammation of the bronchus that spreads to the surrounding alveoli, characterized by white-yellowish foci of condensation.
Lobar Pneumonia
Lobar Pneumonia
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Common Cold
Common Cold
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Viral Sore Throat
Viral Sore Throat
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Influenza
Influenza
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Pneumonia
Pneumonia
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Primary Tuberculosis
Primary Tuberculosis
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Secondary Tuberculosis
Secondary Tuberculosis
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Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD)
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Chronic Bronchitis
Chronic Bronchitis
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Emphysema
Emphysema
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Neoplasia
Neoplasia
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Tumor
Tumor
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Cancer
Cancer
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Oncology
Oncology
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Pathologist
Pathologist
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Oncologist
Oncologist
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Benign Tumor
Benign Tumor
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Malignant Tumor
Malignant Tumor
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Allergic Asthma (Type 1)
Allergic Asthma (Type 1)
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Bronchial Carcinoma
Bronchial Carcinoma
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Metastasis
Metastasis
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Local Spread
Local Spread
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Lymphatic Spread
Lymphatic Spread
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Bloodborne Spread
Bloodborne Spread
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Paraneoplastic Syndromes
Paraneoplastic Syndromes
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Adenocarcinoma
Adenocarcinoma
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Nosocomial Pneumonia
Nosocomial Pneumonia
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Methicillin-Resistant Staphylococcus Aureus (MRSA)
Methicillin-Resistant Staphylococcus Aureus (MRSA)
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Streptococcus Pneumoniae
Streptococcus Pneumoniae
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Pleural Adhesions
Pleural Adhesions
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Defenses of the Respiratory Tract
Defenses of the Respiratory Tract
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Secondary Bacterial Infection
Secondary Bacterial Infection
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Identify the Organism
Identify the Organism
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Aetiology of Pneumonia
Aetiology of Pneumonia
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Community-Acquired Acute Pneumonia (CA-Pneumonia)
Community-Acquired Acute Pneumonia (CA-Pneumonia)
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Impaired Respiratory Defenses
Impaired Respiratory Defenses
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Aspiration Pneumonia
Aspiration Pneumonia
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Allergic Pneumonia
Allergic Pneumonia
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Viral Pneumonia
Viral Pneumonia
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What is COPD?
What is COPD?
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What is Emphysema?
What is Emphysema?
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What is Chronic Bronchitis?
What is Chronic Bronchitis?
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What is Asthma?
What is Asthma?
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What is Status Asthmaticus?
What is Status Asthmaticus?
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What's the primary cause of Emphysema?
What's the primary cause of Emphysema?
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What is Allergic Asthma?
What is Allergic Asthma?
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What are Bronchi?
What are Bronchi?
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What are Alveoli?
What are Alveoli?
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What is Cor Pulmonale?
What is Cor Pulmonale?
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Atopic Asthma
Atopic Asthma
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Occupational Asthma
Occupational Asthma
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Type I Hypersensitivity
Type I Hypersensitivity
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Squamous Cell Carcinoma
Squamous Cell Carcinoma
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Neuroendocrine Carcinoma
Neuroendocrine Carcinoma
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Local Spread (Lung Cancer)
Local Spread (Lung Cancer)
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Lymphatic Spread (Lung Cancer)
Lymphatic Spread (Lung Cancer)
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Bloodborne Spread (Lung Cancer)
Bloodborne Spread (Lung Cancer)
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Study Notes
The Respiratory System
- The upper respiratory tract (upper RT) includes the nose, sinuses, larynx, trachea, and main bronchi.
- The lower respiratory tract (lower RT) includes the bronchi, terminal bronchi, and lung parenchyma.
- Upper RT Symptoms (Mild/Transient): Viral infections are common, causing often trivial or mild and transient conditions.
- Lower RT Symptoms (Serious/Mortality): Bacteria, viruses, or atypical fungi can cause more serious conditions, frequently associated with morbidity and mortality, and often secondary to irritants.
- Lower RT Infections: Respiratory syncytial virus (RSV), influenza virus, adenovirus, SARS-CoV-2, and various bacterial species (e.g., S. pneumoniae, S. aureus, H. influenzae type b, K. pneumoniae, P. aeruginosa) are possible causes. Upper respiratory tract infections may also be viral and bacterial.
Respiratory Organs' Defense Mechanisms
- Cough reflex (aspiration)
- Nasal hairs
- Ciliary apparatus
- Secretion of IgA antibodies
- Phagocytic activity by alveolar macrophages
- Accumulation of secretions
- Alveolar fluid
- Cell-mediated immunity (chronic diseases)
- Virulent infections
- Primary infections (viral, bacterial, mycoplasma, fungal)
- Secondary bacterial infections (following a viral infection)
- Secondary to irritants
Viral Infections
- Common Cold: Acute inflammation of eyes and throat, with watery exudate. Secondary bacterial infection is possible.
- Viral Sore Throat: Adenovirus causes pharyngitis; secondary bacterial infection (purulent pus) is possible.
- Influenza: Primarily affects the upper respiratory tract; accompanied by fever, fatigue, and in serious cases, progresses to pneumonia.
Bacterial Infections
- Streptococcus Pyogenes: Can cause acute laryngitis/epiglottitis and pneumonia.
- Haemophilus influenzae type B/Streptococcus Pyogenes: Associated with pneumonia.
- Pneumonia: Infection of alveolar spaces causing inflammation and exudates. Complications may include pleurisy. Bacterial pneumonia often leads to more serious illness.
Bronchopneumonia
- Inflammation in bronchi, spreading to adjacent alveolar spaces.
- Common bacterial causes include Streptococcus pneumoniae, Staphylococcus Aureus, Haemophilus influenzae, and other bacteria.
- Characterized by white, yellowish foci of condensation.
Lobar Pneumonia
- Inflammation within an entire lobe.
- Caused by Streptococcus pneumoniae (90-95% of cases).
- Characterized by congestion, red and grey hepatization.
- Viral pneumonia includes interstitial pneumonia, which is initially atypical. Viral causes can include Influenza A, B, Adenovirus, SARS-CoV, and other viruses; these infections are typically less severe than bacterial infections.
Pulmonary Tuberculosis
- Primary tuberculosis in childhood may occur but is rare.
- Caused by Mycobacterium tuberculosis. This typically spreads through airborne droplets and can be an infection in itself or a secondary infection.
The Respiratory System 2
- Chronic Bronchitis: Persistent cough with sputum production.
- Emphysema: Weakening of air spaces, often due to destruction of alveolar walls, contributing to COPD.
- COPD: Chronic bronchitis and emphysema frequently overlap; they can result in widespread air obstruction.
- The pathogenesis of emphysema involves an imbalance between proteases and antiproteases, damaging lung tissue.
- Asthma: Bronchial airways constrict, often through allergic reactions, irritant stimuli, or other triggers; airways are often clogged with thick mucous plugs.
Classification of Malignant Lung Tumors
- Epithelial (90-95%):
- Non-small cell carcinoma (70-80%): Squamous cell, Adenocarcinoma, Large cell carcinoma
- Small cell carcinoma (20-25%): Oat cell
Bronchial Carcinoma
- Incidence is high in the 40-70-year-old demographic.
- Cigarettes are a primary causal factor.
Prognosis of Lung Tumors
- Surgical resection, when possible, offers a better prognosis.
- 30-40% 5-year survival rate for patients who undergo surgical intervention.
Spread and Metastasis
- Lung tumors can spread locally, through lymphatics (e.g., hilar, cervical), and through blood vessels (e.g., causing lesions in the liver, adrenal glands).
- Non-metastatic systemic effects such as finger clubbing and cachexia may manifest.
- Secondary tumors may be found at multiple sites.
Secondary Lung Tumors
- Metastases from other primary cancers.
- Multiple nodules spread throughout the lungs.
- May arise from different organ systems (e.g., breast, kidney, testis).
Neoplasia
- Neoplasia: New growth, benign or malignant.
- Tumor: New growth (benign or malignant).
- Cancer: Malignant new growth.
- Oncology: Study of cancer.
- Pathologist: Studies disease in general.
- Oncologist: Treats cancer patients.
- Benign tumors (suffix -oma) cannot metastasize but can still be lethal (e.g., CNS tumors).
- Malignant tumors (e.g., -carcinoma) have the ability to invade and spread.
- Differentiation represents the resemblance of the cancer to its original tissue type.
- Pleomorphism: Variation in the size and shape of cancer cells.
- Mitotically Active: Rapid cell division and proliferation.
Cell Types
- Epithelium: Lining tissue
- Mesenchymal: Bone, cartilage, muscle
- Germ cell: Reproductive systems (e.g., testes, ovaries)
- Benign: Cannot metastasize (spread) but can be lethal.
- Malignant: Cancer spreads from original site.
Epidemiology
- Epidemiology: Study of disease occurrence in different populations. Factors like environment, age, and occupational exposures are key influences.
- Environmental Factors: A major factor in many diseases.
- Ageing Population: Increase in cancer cases, including lung cancers, with age.
- Iatrogenic Factors: Medical treatments, like chemotherapy, can provoke cancer as a side effect.
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