Pulmonary Alveolar Proteinosis (PAP) Quiz
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Questions and Answers

What is the primary cause of autoimmune PAP?

  • Deficient surfactant production
  • Overexpression of GM-CSF
  • Impaired alveolar macrophage migration
  • Autoantibodies binding and neutralizing GM-CSF (correct)

    • Which class of PAP lacks familial predisposition?

  • Secondary
  • Congenital
  • Autoimmune (correct)
  • All classes have familial predisposition

    • What is the effect of GM-CSF gene knockout in mice?

  • No effect on PAP
  • Induces PAP (correct)
  • Increases surfactant production
  • Cures PAP

    • What is the characteristic radiological feature of PAP?

    <p>Bilateral patchy asymmetric pulmonary opacifications</p> Signup and view all the answers

    How does loss of GM-CSF signaling affect alveolar macrophages?

    <p>Blocks their terminal differentiation</p> Signup and view all the answers

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