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Questions and Answers
What is the primary cause of autoimmune PAP?
What is the primary cause of autoimmune PAP?
- Deficient surfactant production
- Overexpression of GM-CSF
- Impaired alveolar macrophage migration
- Autoantibodies binding and neutralizing GM-CSF (correct)
Which class of PAP lacks familial predisposition?
Which class of PAP lacks familial predisposition?
- Secondary
- Congenital
- Autoimmune (correct)
- All classes have familial predisposition
What is the effect of GM-CSF gene knockout in mice?
What is the effect of GM-CSF gene knockout in mice?
- No effect on PAP
- Induces PAP (correct)
- Increases surfactant production
- Cures PAP
What is the characteristic radiological feature of PAP?
What is the characteristic radiological feature of PAP?
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How does loss of GM-CSF signaling affect alveolar macrophages?
How does loss of GM-CSF signaling affect alveolar macrophages?
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