Psychopharmacology and Pharmacokinetics

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Questions and Answers

Which of the following best describes the focus of psychopharmacology?

  • The study of all drugs and their effects on the body.
  • The study of the psychological effects of illegal drugs exclusively.
  • The study of how drugs affect the nervous system and behavior. (correct)
  • The study of drugs that affect body systems other than the nervous system.

Which category includes drugs like heroin and cocaine?

  • Drugs of abuse. (correct)
  • Blood pressure medications.
  • Antibiotics.
  • Therapeutic drugs.

Antidepressants and antipsychotics are examples of what kind of drugs?

  • Drugs of abuse.
  • Recreational drugs.
  • Therapeutic drugs. (correct)
  • Experimental drugs.

Which of the following best describes pharmacokinetics?

<p>What the body does to the drug. (A)</p> Signup and view all the answers

Which of the following is NOT a component of pharmacokinetics (ADME)?

<p>Efficacy (D)</p> Signup and view all the answers

What does 'ADME' stand for in the context of pharmacokinetics?

<p>Absorption, Distribution, Metabolism, Excretion. (B)</p> Signup and view all the answers

Which of the following is the study of 'what the drug does to the body'?

<p>Pharmacodynamics. (D)</p> Signup and view all the answers

Affinity, efficacy, and potency are components of?

<p>Pharmacodynamics (PD) (C)</p> Signup and view all the answers

Which of the following drug classes is known for causing general suppression and relaxation?

<p>CNS Depressants (D)</p> Signup and view all the answers

Which drug class is primarily associated with pain relief and altered psychological experiences?

<p>Analgesics (B)</p> Signup and view all the answers

Which drug class is best known for altering perceptual experiences?

<p>Hallucinogens (D)</p> Signup and view all the answers

Which route of administration generally leads to a faster effect compared to oral administration?

<p>Inhalation (A)</p> Signup and view all the answers

Which route of administration has a bioavailability of 100% by definition?

<p>Intravenous (A)</p> Signup and view all the answers

What is the primary reason that smoking cannabis leads to a stronger effect compared to ingesting it in a brownie?

<p>Smoking leads to faster absorption and bypasses first-pass liver metabolism. (D)</p> Signup and view all the answers

If a drug is administered orally, where does it go before entering systemic circulation?

<p>Through the liver. (B)</p> Signup and view all the answers

What is the impact of grapefruit juice on certain drugs that undergo first-pass metabolism?

<p>Decreases the activity of P450 enzymes, potentially increasing drug bioavailability. (B)</p> Signup and view all the answers

What is the blood-brain barrier's (BBB) primary function?

<p>To protect the brain by restricting the entry of water-soluble molecules. (C)</p> Signup and view all the answers

Which type of molecule can typically cross the blood-brain barrier more easily?

<p>Lipid-soluble molecules (D)</p> Signup and view all the answers

Why might drugs that are administered via inhalation or injection have a greater risk of addiction compared to those taken orally?

<p>They lead to faster delivery and more powerful associations with the reward pathway. (A)</p> Signup and view all the answers

Where do psychoactive drugs typically exert their effects in the body?

<p>Brain Regions (A)</p> Signup and view all the answers

What does the term 'bioavailability' refer to in pharmacokinetics?

<p>The proportion of a drug that enters the circulation and is able to have an active effect. (B)</p> Signup and view all the answers

Which of the following factors can influence a drug's bioavailability?

<p>All of the above. (D)</p> Signup and view all the answers

What is the primary role of the liver in pharmacokinetics?

<p>Metabolism. (C)</p> Signup and view all the answers

Besides the liver, which of the following is a key organ involved in the elimination of drugs from the body?

<p>Kidneys (A)</p> Signup and view all the answers

What is meant by the 'half-life' of a drug?

<p>The time required for the amount of drug in the body to be reduced by half. (C)</p> Signup and view all the answers

Roughly how many half-lives does it typically take to effectively remove a drug from the body?

<p>5.5 (B)</p> Signup and view all the answers

Which of the following would NOT impact a drug's effectiveness?

<p>Ligand size (B)</p> Signup and view all the answers

Which term refers to the strength of binding between a drug and its receptor?

<p>Affinity (C)</p> Signup and view all the answers

What distinguishes an agonist from an antagonist?

<p>Agonists bind to a receptor and activate it; antagonists bind and block activation. (B)</p> Signup and view all the answers

If a drug blocks the reuptake of a neurotransmitter, what effect would that have on synaptic transmission?

<p>Increase. (A)</p> Signup and view all the answers

If a drug inactivates acetylcholinesterase, what effect does that have on synaptic activity?

<p>Increase (A)</p> Signup and view all the answers

Which of the following neurotransmitters is primarily associated with feelings of pleasure, motivation, and addiction?

<p>Dopamine (A)</p> Signup and view all the answers

What is the primary function of GABA in the central nervous system?

<p>Inhibition (B)</p> Signup and view all the answers

What is the function of an allosteric modulator at a receptor site?

<p>Enhance or inhibit the response of the receptor to an endogenous ligand. (B)</p> Signup and view all the answers

What is meant by the term 'potency' in pharmacology?

<p>The amount of drug needed to produce a certain response. (B)</p> Signup and view all the answers

What is meant by the term 'efficacy' in pharmacology?

<p>The ability of a drug to produce a desired effect. (D)</p> Signup and view all the answers

Which of the following is true of a drug with high efficacy and low potency?

<p>Requires a large dose to achieve the desired effect but can produce a large maximal effect. (D)</p> Signup and view all the answers

What is a partial agonist?

<p>A drug that, no matter the dose, cannot elicit a maximal response. (C)</p> Signup and view all the answers

If a partial agonist and a full agonist are available and compete for the same receptor, what result would you expect?

<p>The partial agonist would decrease the effect of the full agonist. (A)</p> Signup and view all the answers

What is the therapeutic index?

<p>A ratio of the dose that produces the desired effect to the dose that produces a toxic effect. (B)</p> Signup and view all the answers

Which statement best describes tolerance?

<p>Decreasing response to a drug. (C)</p> Signup and view all the answers

What best describes sensitization?

<p>Increased response to a drug. (D)</p> Signup and view all the answers

What is a key difference between drug tolerance and drug sensitization?

<p>Tolerance involves a decreased response to a drug, while sensitization involves an increased response. (C)</p> Signup and view all the answers

If a drug has a high affinity for a receptor but doesn't activate it, what is it classified as?

<p>Antagonist (D)</p> Signup and view all the answers

How do allosteric modulators affect receptor activity?

<p>By binding to a different site on the receptor, altering its response to the endogenous ligand (D)</p> Signup and view all the answers

What is the primary effect of a CNS stimulant?

<p>General activation and arousal (B)</p> Signup and view all the answers

Which of the following best describes the function of an analgesic?

<p>To provide pain relief and potentially alter psychological experience (A)</p> Signup and view all the answers

What is the most direct route of drug administration that bypasses the stomach?

<p>Intravenous (C)</p> Signup and view all the answers

How does the rate of drug delivery typically influence addiction potential?

<p>Faster delivery is associated with a greater risk of addiction. (B)</p> Signup and view all the answers

What property allows molecules to cross the blood-brain barrier more easily?

<p>Lipid solubility (B)</p> Signup and view all the answers

What is the role of the liver in drug metabolism?

<p>To chemically modify drugs, often inactivating them (B)</p> Signup and view all the answers

After approximately how many half-lives is a drug considered effectively eliminated from the body?

<p>5-6 (C)</p> Signup and view all the answers

Which of the following describes the relationship between drug potency and the amount of drug needed for an effect?

<p>High potency means a small amount of drug is needed. (D)</p> Signup and view all the answers

What happens when a partial agonist competes with a full agonist for the same receptor?

<p>The partial agonist will reduce the effect of the full agonist. (B)</p> Signup and view all the answers

What does a large therapeutic index indicate about a drug?

<p>The drug has a large margin of safety. (A)</p> Signup and view all the answers

How does metabolic tolerance typically affect drug dosage over time?

<p>The required dosage increases to achieve the same effect. (D)</p> Signup and view all the answers

Which of the following is a key characteristic of drug sensitization?

<p>Increased response to the same dose of a drug (B)</p> Signup and view all the answers

How does activation of GABA receptors typically affect neuronal activity in the central nervous system?

<p>It decreases neuronal firing and causes inhibition. (B)</p> Signup and view all the answers

If a drug prevents the storage of a neurotransmitter in vesicles, what effect would that have on synaptic transmission?

<p>Decreased neurotransmitter release (D)</p> Signup and view all the answers

What is a primary mechanism of action for alcohol as a depressant?

<p>Allosteric agonist for GABA receptors (D)</p> Signup and view all the answers

How do stimulant drugs like methamphetamine primarily exert their effects at the synapse?

<p>By inducing the release of monoamines and reversing reuptake transporters (D)</p> Signup and view all the answers

A drug is found to have a higher efficacy but lower potency than another drug. What can be concluded?

<p>It requires a higher dose to achieve maximal effect but can produce a larger overall effect. (A)</p> Signup and view all the answers

Why might drugs that bypass first-pass metabolism, such as those administered intravenously or by inhalation, have a higher addiction potential?

<p>They lead to higher peak drug concentrations in the brain more quickly. (A)</p> Signup and view all the answers

If a drug has a very short half-life, how does this affect how frequently it must be administered?

<p>It must be administered more frequently to maintain therapeutic levels. (C)</p> Signup and view all the answers

Which of the following occurs during sensitization?

<p>An increased response to the drug (A)</p> Signup and view all the answers

Which of the following is an example of distribution?

<p>Drug molecules being transported across the blood-brain barrier to reach target sites. (C)</p> Signup and view all the answers

If someone's body is better able to eliminate a drug, what effect does that have on the half-life?

<p>The half-life decreases. (C)</p> Signup and view all the answers

How does heroin impact the body as an analgesic?

<p>Stimulates endogenous opioids (A)</p> Signup and view all the answers

How does the potency and efficacy of Drug A compare to Drug B? - Drug A: ED50 = 10mg, Emax = 80% - Drug B: ED50 = 5mg, Emax = 60%

<p>Drug A is less potent and more efficacious (C)</p> Signup and view all the answers

What happens when a patient is experiencing metabolic tolerance.

<p>Both B &amp; C (A)</p> Signup and view all the answers

Methamphetamine has one specific effect in the synapse, which is?

<p>Inducing the release of monoamines, reversing reuptake transporters (C)</p> Signup and view all the answers

What is a reason that one might feel a stronger affect from smoking cannabis versus eating it in a brownie?

<p>All the above (A)</p> Signup and view all the answers

How do drugs act agonist or antagonistic?

<p>Both (C)</p> Signup and view all the answers

Which route of administration has the slowest effect?

<p>Oral (A)</p> Signup and view all the answers

A drug preventing storage of neurotransmitters in vesicles has which effect?

<p>Decreased neurotransmitter release (D)</p> Signup and view all the answers

How is a drug able to achieve a effect on the brain?

<p>Lipid Solubility (A)</p> Signup and view all the answers

GABA receptors typically have what effect on the central nervous system?

<p>Decrease neuronal firing (A)</p> Signup and view all the answers

Drug A: ED50 = 20mg Which of the following statements are true?

<p>A &amp; B (B)</p> Signup and view all the answers

A drug prevents degradation of a neurotransmitter. What effect will you observe?

<p>More neurotransmitter in the synapse (C)</p> Signup and view all the answers

Flashcards

What is psychopharmacology?

The study of the effects of drugs on the nervous system and behavior.

What is Pharmacokinetics (ADME)?

The process that involves absorption, distribution, metabolism, and elimination of drugs, describing what the body does to the drug.

What is Pharmacodynamics (PD)?

The study of the sites of action of drugs, including affinity, efficacy, potency, how effectiveness is measured, and the effects of repeated administration. It describes what the drug does to the body.

What are CNS stimulants?

General activation and arousal are functions of this drug class, including (meth)amphetamine, cocaine, caffeine, and nicotine.

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What are CNS depressants?

General suppression and relaxation are functions of this drug class, including alcohol, barbiturates, and benzodiazepines.

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What are Analgesics?

This drug class provides pain relief and altered psychological experience, including opium, morphine, codeine, and heroin.

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What are Hallucinogens?

This drug class alters perceptual experience, including mescaline, LSD, psilocybin, and ecstasy (MDMA).

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What are Diverse CNS effects?

This drug class have medicinal and psychoactive effects, exemplified by marijuana.

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What are Psychotherapeutics?

This drug class therapy target for various mental illnesses, including Ritalin and Thorazine.

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What is Bioavailability?

The proportion of a drug or other substance which enters the circulation when introduced into the body and so is able to have an active effect.

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What is the first pass metabolism?

The process where the concentration of a drug is reduced by the liver before it reaches the systemic circulation

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What is the half-life of a drug?

The time required for the amount of drug in the body to be reduced by one-half.

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What are Agonists?

Drugs that bind to receptors and activate them, mimicking the effects of a neurotransmitter.

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What are Antagonists?

Drugs that bind to receptors but do not activate them; instead, they block the action of agonists or neurotransmitters.

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Name some Neurotransmitters.

Includes adrenaline, noradrenaline, acetylcholine, dopamine, glutamate, serotonin, and endorphins.

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What is Affinity?

The strength of binding between a drug and its receptor.

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What is Efficacy?

The strength of the functional response produced by a drug, compared to an endogenous ligand.

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What is Potency?

How much drug is required to provide a certain response.

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What is a partial agonist?

A drug that binds to the receptor active site but has weak effectiveness in receptor activation.

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What is an allosteric drug?

A drug that binds to a site on the receptor other than where the endogenous ligand binds.

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Describe Dose Response Curve:

Located at the point that relates Dose and maximum effect

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What is Margin of safety?

The dose-response curve for the analgesic effect versus the depressive effect.

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What is Therapeutic Index?

The ratio of the dose that produces the desired therapeutic effect to the dose that produces a toxic effect.

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What is Tolerance?

Decreased response to a drug, where one must take a larger amount to get the same effect.

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What is Withdrawal?

A physiological response opposite to the drug's effects that occurs upon cessation of repeated drug exposure.

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What is Sensitization?

Increased response to the same dose with repeated exposure.

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Study Notes

Here are some study notes.

Psychopharmacology Overview

  • This is the study of drugs affecting the nervous system and behavior
  • It includes drugs for both therapeutic and recreational abuse

Pharmacokinetics (ADME)

  • ADME consists of: Administration, Distribution, Metabolism, and Excretion
  • Administration describes how drugs enter the body
  • Distribution describes how drugs reach the target sites
  • Metabolism and Excretion refers to how drugs are inactivated / removed
  • Route of administration affects the rate of addiction, you are more likely to get addicted smoking vs taking a pill orally
  • The fastest route of administration is IV, while the slowest is oral
  • Bioavailability refers to the proportion of a drug that enters the circulation
  • This is impacted by route of administration, hydrophobic properties, and enzymes as well as diet, personal metabolism and digestive state
  • The blood brain barrier (BBB) is a barrier to water soluble molecules, but lipid soluble molecules can easily pass
  • Repeated administration can lead to tolerance, withdrawal and sensitization
  • Tolerance is when the response to a drug decreases, and one must take a larger amount to get the same effect
  • There are multiple types of tolerance: Metabolic, Cellular, and Behavioral
  • Withdrawal is when one experiences the opposite response to the drug when not taking it; this can be physical and/or psychological
  • Sensitization describes the amplification of a drug's effects after repeated administration

Pharmacodynamics

  • Pharmacodynamics is the study of the molecular, biochemical, and physiological effects of drugs
  • It has various elements: Sites of Action, Affinity, efficacy, potency, Measuring drug effectiveness, Repeated administration effects and Categorization of psychoactive drugs
  • Agonists bind to receptors and activate them
  • Antagonists bind to receptors and block them

Affinity and Efficacy

  • Affinity describes the strength of binding between a drug and its target
  • Efficacy describes the strength of the functional response of a drug, compared to an endogenous ligand
  • A full agonist has an efficacy of 1
  • A partial agonist has an efficacy greater than 0 but less than 1
  • An antagonist has an efficacy of 0
  • The therapeutic index has correlation to safety.

Psychoactive Drug Classes

  • CNS stimulants generally activate and arouse the nervous system; examples include (meth)amphetamine, cocaine, caffeine, and nicotine
  • CNS depressants generally suppress and relax the nervous system; examples include alcohol, barbiturates (Nembutal, aspirin), and benzodiazepines (Xanax, valium)
  • Analgesics relieve pain and alter psychological experience; examples include opium, morphine, codeine, and heroin
  • Hallucinogens alter perceptual experience; examples include mescaline, LSD, psilocybin, and (Ecstasy/MDMA)
  • Diverse CNS effects can be medicinal and psychoactive like Marijuana
  • Psychotherapeutics target various mental illnesses examples: Prozac, Ritalin Thorazine

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