Podcast
Questions and Answers
Which of the following best describes the focus of psychopharmacology?
Which of the following best describes the focus of psychopharmacology?
- The study of all drugs and their effects on the body.
- The study of the psychological effects of illegal drugs exclusively.
- The study of how drugs affect the nervous system and behavior. (correct)
- The study of drugs that affect body systems other than the nervous system.
Which category includes drugs like heroin and cocaine?
Which category includes drugs like heroin and cocaine?
- Drugs of abuse. (correct)
- Blood pressure medications.
- Antibiotics.
- Therapeutic drugs.
Antidepressants and antipsychotics are examples of what kind of drugs?
Antidepressants and antipsychotics are examples of what kind of drugs?
- Drugs of abuse.
- Recreational drugs.
- Therapeutic drugs. (correct)
- Experimental drugs.
Which of the following best describes pharmacokinetics?
Which of the following best describes pharmacokinetics?
Which of the following is NOT a component of pharmacokinetics (ADME)?
Which of the following is NOT a component of pharmacokinetics (ADME)?
What does 'ADME' stand for in the context of pharmacokinetics?
What does 'ADME' stand for in the context of pharmacokinetics?
Which of the following is the study of 'what the drug does to the body'?
Which of the following is the study of 'what the drug does to the body'?
Affinity, efficacy, and potency are components of?
Affinity, efficacy, and potency are components of?
Which of the following drug classes is known for causing general suppression and relaxation?
Which of the following drug classes is known for causing general suppression and relaxation?
Which drug class is primarily associated with pain relief and altered psychological experiences?
Which drug class is primarily associated with pain relief and altered psychological experiences?
Which drug class is best known for altering perceptual experiences?
Which drug class is best known for altering perceptual experiences?
Which route of administration generally leads to a faster effect compared to oral administration?
Which route of administration generally leads to a faster effect compared to oral administration?
Which route of administration has a bioavailability of 100% by definition?
Which route of administration has a bioavailability of 100% by definition?
What is the primary reason that smoking cannabis leads to a stronger effect compared to ingesting it in a brownie?
What is the primary reason that smoking cannabis leads to a stronger effect compared to ingesting it in a brownie?
If a drug is administered orally, where does it go before entering systemic circulation?
If a drug is administered orally, where does it go before entering systemic circulation?
What is the impact of grapefruit juice on certain drugs that undergo first-pass metabolism?
What is the impact of grapefruit juice on certain drugs that undergo first-pass metabolism?
What is the blood-brain barrier's (BBB) primary function?
What is the blood-brain barrier's (BBB) primary function?
Which type of molecule can typically cross the blood-brain barrier more easily?
Which type of molecule can typically cross the blood-brain barrier more easily?
Why might drugs that are administered via inhalation or injection have a greater risk of addiction compared to those taken orally?
Why might drugs that are administered via inhalation or injection have a greater risk of addiction compared to those taken orally?
Where do psychoactive drugs typically exert their effects in the body?
Where do psychoactive drugs typically exert their effects in the body?
What does the term 'bioavailability' refer to in pharmacokinetics?
What does the term 'bioavailability' refer to in pharmacokinetics?
Which of the following factors can influence a drug's bioavailability?
Which of the following factors can influence a drug's bioavailability?
What is the primary role of the liver in pharmacokinetics?
What is the primary role of the liver in pharmacokinetics?
Besides the liver, which of the following is a key organ involved in the elimination of drugs from the body?
Besides the liver, which of the following is a key organ involved in the elimination of drugs from the body?
What is meant by the 'half-life' of a drug?
What is meant by the 'half-life' of a drug?
Roughly how many half-lives does it typically take to effectively remove a drug from the body?
Roughly how many half-lives does it typically take to effectively remove a drug from the body?
Which of the following would NOT impact a drug's effectiveness?
Which of the following would NOT impact a drug's effectiveness?
Which term refers to the strength of binding between a drug and its receptor?
Which term refers to the strength of binding between a drug and its receptor?
What distinguishes an agonist from an antagonist?
What distinguishes an agonist from an antagonist?
If a drug blocks the reuptake of a neurotransmitter, what effect would that have on synaptic transmission?
If a drug blocks the reuptake of a neurotransmitter, what effect would that have on synaptic transmission?
If a drug inactivates acetylcholinesterase, what effect does that have on synaptic activity?
If a drug inactivates acetylcholinesterase, what effect does that have on synaptic activity?
Which of the following neurotransmitters is primarily associated with feelings of pleasure, motivation, and addiction?
Which of the following neurotransmitters is primarily associated with feelings of pleasure, motivation, and addiction?
What is the primary function of GABA in the central nervous system?
What is the primary function of GABA in the central nervous system?
What is the function of an allosteric modulator at a receptor site?
What is the function of an allosteric modulator at a receptor site?
What is meant by the term 'potency' in pharmacology?
What is meant by the term 'potency' in pharmacology?
What is meant by the term 'efficacy' in pharmacology?
What is meant by the term 'efficacy' in pharmacology?
Which of the following is true of a drug with high efficacy and low potency?
Which of the following is true of a drug with high efficacy and low potency?
What is a partial agonist?
What is a partial agonist?
If a partial agonist and a full agonist are available and compete for the same receptor, what result would you expect?
If a partial agonist and a full agonist are available and compete for the same receptor, what result would you expect?
What is the therapeutic index?
What is the therapeutic index?
Which statement best describes tolerance?
Which statement best describes tolerance?
What best describes sensitization?
What best describes sensitization?
What is a key difference between drug tolerance and drug sensitization?
What is a key difference between drug tolerance and drug sensitization?
If a drug has a high affinity for a receptor but doesn't activate it, what is it classified as?
If a drug has a high affinity for a receptor but doesn't activate it, what is it classified as?
How do allosteric modulators affect receptor activity?
How do allosteric modulators affect receptor activity?
What is the primary effect of a CNS stimulant?
What is the primary effect of a CNS stimulant?
Which of the following best describes the function of an analgesic?
Which of the following best describes the function of an analgesic?
What is the most direct route of drug administration that bypasses the stomach?
What is the most direct route of drug administration that bypasses the stomach?
How does the rate of drug delivery typically influence addiction potential?
How does the rate of drug delivery typically influence addiction potential?
What property allows molecules to cross the blood-brain barrier more easily?
What property allows molecules to cross the blood-brain barrier more easily?
What is the role of the liver in drug metabolism?
What is the role of the liver in drug metabolism?
After approximately how many half-lives is a drug considered effectively eliminated from the body?
After approximately how many half-lives is a drug considered effectively eliminated from the body?
Which of the following describes the relationship between drug potency and the amount of drug needed for an effect?
Which of the following describes the relationship between drug potency and the amount of drug needed for an effect?
What happens when a partial agonist competes with a full agonist for the same receptor?
What happens when a partial agonist competes with a full agonist for the same receptor?
What does a large therapeutic index indicate about a drug?
What does a large therapeutic index indicate about a drug?
How does metabolic tolerance typically affect drug dosage over time?
How does metabolic tolerance typically affect drug dosage over time?
Which of the following is a key characteristic of drug sensitization?
Which of the following is a key characteristic of drug sensitization?
How does activation of GABA receptors typically affect neuronal activity in the central nervous system?
How does activation of GABA receptors typically affect neuronal activity in the central nervous system?
If a drug prevents the storage of a neurotransmitter in vesicles, what effect would that have on synaptic transmission?
If a drug prevents the storage of a neurotransmitter in vesicles, what effect would that have on synaptic transmission?
What is a primary mechanism of action for alcohol as a depressant?
What is a primary mechanism of action for alcohol as a depressant?
How do stimulant drugs like methamphetamine primarily exert their effects at the synapse?
How do stimulant drugs like methamphetamine primarily exert their effects at the synapse?
A drug is found to have a higher efficacy but lower potency than another drug. What can be concluded?
A drug is found to have a higher efficacy but lower potency than another drug. What can be concluded?
Why might drugs that bypass first-pass metabolism, such as those administered intravenously or by inhalation, have a higher addiction potential?
Why might drugs that bypass first-pass metabolism, such as those administered intravenously or by inhalation, have a higher addiction potential?
If a drug has a very short half-life, how does this affect how frequently it must be administered?
If a drug has a very short half-life, how does this affect how frequently it must be administered?
Which of the following occurs during sensitization?
Which of the following occurs during sensitization?
Which of the following is an example of distribution?
Which of the following is an example of distribution?
If someone's body is better able to eliminate a drug, what effect does that have on the half-life?
If someone's body is better able to eliminate a drug, what effect does that have on the half-life?
How does heroin impact the body as an analgesic?
How does heroin impact the body as an analgesic?
How does the potency and efficacy of Drug A compare to Drug B? - Drug A: ED50 = 10mg, Emax = 80% - Drug B: ED50 = 5mg, Emax = 60%
How does the potency and efficacy of Drug A compare to Drug B? - Drug A: ED50 = 10mg, Emax = 80% - Drug B: ED50 = 5mg, Emax = 60%
What happens when a patient is experiencing metabolic tolerance.
What happens when a patient is experiencing metabolic tolerance.
Methamphetamine has one specific effect in the synapse, which is?
Methamphetamine has one specific effect in the synapse, which is?
What is a reason that one might feel a stronger affect from smoking cannabis versus eating it in a brownie?
What is a reason that one might feel a stronger affect from smoking cannabis versus eating it in a brownie?
How do drugs act agonist or antagonistic?
How do drugs act agonist or antagonistic?
Which route of administration has the slowest effect?
Which route of administration has the slowest effect?
A drug preventing storage of neurotransmitters in vesicles has which effect?
A drug preventing storage of neurotransmitters in vesicles has which effect?
How is a drug able to achieve a effect on the brain?
How is a drug able to achieve a effect on the brain?
GABA receptors typically have what effect on the central nervous system?
GABA receptors typically have what effect on the central nervous system?
Drug A: ED50 = 20mg Which of the following statements are true?
Drug A: ED50 = 20mg Which of the following statements are true?
A drug prevents degradation of a neurotransmitter. What effect will you observe?
A drug prevents degradation of a neurotransmitter. What effect will you observe?
Flashcards
What is psychopharmacology?
What is psychopharmacology?
The study of the effects of drugs on the nervous system and behavior.
What is Pharmacokinetics (ADME)?
What is Pharmacokinetics (ADME)?
The process that involves absorption, distribution, metabolism, and elimination of drugs, describing what the body does to the drug.
What is Pharmacodynamics (PD)?
What is Pharmacodynamics (PD)?
The study of the sites of action of drugs, including affinity, efficacy, potency, how effectiveness is measured, and the effects of repeated administration. It describes what the drug does to the body.
What are CNS stimulants?
What are CNS stimulants?
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What are CNS depressants?
What are CNS depressants?
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What are Analgesics?
What are Analgesics?
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What are Hallucinogens?
What are Hallucinogens?
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What are Diverse CNS effects?
What are Diverse CNS effects?
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What are Psychotherapeutics?
What are Psychotherapeutics?
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What is Bioavailability?
What is Bioavailability?
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What is the first pass metabolism?
What is the first pass metabolism?
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What is the half-life of a drug?
What is the half-life of a drug?
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What are Agonists?
What are Agonists?
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What are Antagonists?
What are Antagonists?
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Name some Neurotransmitters.
Name some Neurotransmitters.
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What is Affinity?
What is Affinity?
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What is Efficacy?
What is Efficacy?
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What is Potency?
What is Potency?
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What is a partial agonist?
What is a partial agonist?
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What is an allosteric drug?
What is an allosteric drug?
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Describe Dose Response Curve:
Describe Dose Response Curve:
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What is Margin of safety?
What is Margin of safety?
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What is Therapeutic Index?
What is Therapeutic Index?
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What is Tolerance?
What is Tolerance?
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What is Withdrawal?
What is Withdrawal?
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What is Sensitization?
What is Sensitization?
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Study Notes
Here are some study notes.
Psychopharmacology Overview
- This is the study of drugs affecting the nervous system and behavior
- It includes drugs for both therapeutic and recreational abuse
Pharmacokinetics (ADME)
- ADME consists of: Administration, Distribution, Metabolism, and Excretion
- Administration describes how drugs enter the body
- Distribution describes how drugs reach the target sites
- Metabolism and Excretion refers to how drugs are inactivated / removed
- Route of administration affects the rate of addiction, you are more likely to get addicted smoking vs taking a pill orally
- The fastest route of administration is IV, while the slowest is oral
- Bioavailability refers to the proportion of a drug that enters the circulation
- This is impacted by route of administration, hydrophobic properties, and enzymes as well as diet, personal metabolism and digestive state
- The blood brain barrier (BBB) is a barrier to water soluble molecules, but lipid soluble molecules can easily pass
- Repeated administration can lead to tolerance, withdrawal and sensitization
- Tolerance is when the response to a drug decreases, and one must take a larger amount to get the same effect
- There are multiple types of tolerance: Metabolic, Cellular, and Behavioral
- Withdrawal is when one experiences the opposite response to the drug when not taking it; this can be physical and/or psychological
- Sensitization describes the amplification of a drug's effects after repeated administration
Pharmacodynamics
- Pharmacodynamics is the study of the molecular, biochemical, and physiological effects of drugs
- It has various elements: Sites of Action, Affinity, efficacy, potency, Measuring drug effectiveness, Repeated administration effects and Categorization of psychoactive drugs
- Agonists bind to receptors and activate them
- Antagonists bind to receptors and block them
Affinity and Efficacy
- Affinity describes the strength of binding between a drug and its target
- Efficacy describes the strength of the functional response of a drug, compared to an endogenous ligand
- A full agonist has an efficacy of 1
- A partial agonist has an efficacy greater than 0 but less than 1
- An antagonist has an efficacy of 0
- The therapeutic index has correlation to safety.
Psychoactive Drug Classes
- CNS stimulants generally activate and arouse the nervous system; examples include (meth)amphetamine, cocaine, caffeine, and nicotine
- CNS depressants generally suppress and relax the nervous system; examples include alcohol, barbiturates (Nembutal, aspirin), and benzodiazepines (Xanax, valium)
- Analgesics relieve pain and alter psychological experience; examples include opium, morphine, codeine, and heroin
- Hallucinogens alter perceptual experience; examples include mescaline, LSD, psilocybin, and (Ecstasy/MDMA)
- Diverse CNS effects can be medicinal and psychoactive like Marijuana
- Psychotherapeutics target various mental illnesses examples: Prozac, Ritalin Thorazine
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