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What are the consequences of substance abuse on the central nervous system?
What are the consequences of substance abuse on the central nervous system?
What is a characteristic of withdrawal syndrome?
What is a characteristic of withdrawal syndrome?
Which of the following is a common comorbidity with substance abuse disorders?
Which of the following is a common comorbidity with substance abuse disorders?
What is a critical factor in diagnosing withdrawal syndrome?
What is a critical factor in diagnosing withdrawal syndrome?
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What is a potential long-term effect of substance abuse on the brain?
What is a potential long-term effect of substance abuse on the brain?
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What is a key feature of substance-induced psychosis?
What is a key feature of substance-induced psychosis?
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What is a characteristic symptom of pathological intoxication?
What is a characteristic symptom of pathological intoxication?
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What is a common symptom of uncomplicated alcohol withdrawal?
What is a common symptom of uncomplicated alcohol withdrawal?
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What is a common complication of opiate overdose?
What is a common complication of opiate overdose?
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What is a characteristic feature of substance-induced psychosis?
What is a characteristic feature of substance-induced psychosis?
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What is a common neurological effect of substance abuse?
What is a common neurological effect of substance abuse?
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What is a characteristic symptom of withdrawal syndrome?
What is a characteristic symptom of withdrawal syndrome?
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What is a common diagnostic criterion for substance use disorder?
What is a common diagnostic criterion for substance use disorder?
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What is a common investigation used to prepare a patient for treatment?
What is a common investigation used to prepare a patient for treatment?
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What is characterized by physiologic signs and symptoms in addition to psychological changes?
What is characterized by physiologic signs and symptoms in addition to psychological changes?
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Which of the following is a characteristic of substance dependence?
Which of the following is a characteristic of substance dependence?
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What is the ability of one drug to be substituted for another, producing the same physiologic and psychological effect?
What is the ability of one drug to be substituted for another, producing the same physiologic and psychological effect?
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Which of the following is a symptom of substance dependence?
Which of the following is a symptom of substance dependence?
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What is the term for the phenomenon in which a given dose of a drug produces a decreased effect or increasingly larger doses must be administered to obtain the effect?
What is the term for the phenomenon in which a given dose of a drug produces a decreased effect or increasingly larger doses must be administered to obtain the effect?
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Which of the following is a diagnostic criterion for substance dependence?
Which of the following is a diagnostic criterion for substance dependence?
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Study Notes
Substance-Related Disorders
- A substance-specific syndrome occurs after stopping or reducing the amount of a drug used regularly over a prolonged period, characterized by physiologic signs and symptoms, and psychological changes.
Tolerance
- Phenomenon where repeated administration of a drug leads to decreased effect, requiring increasingly larger doses to obtain the original effect.
- Cross-tolerance refers to the ability of one drug to be substituted for another, producing the same physiologic and psychological effect.
Diagnosis of Substance Dependence
- Need for markedly increased amounts of the substance.
- Diminished effect.
- Characteristic withdrawal syndrome.
- Taking the substance in larger amounts or over a longer period.
- Unable to cut down or control substance use.
- Significant amount of time spent in activities necessary to obtain the substance.
- Behavioral/psychological changes due to effects on CNS developing after ingestion.
Withdrawal
- Substance-specific syndrome characterized by problematic behavioral change due to stopping or reducing prolonged substance use.
- Physiological and psychological components with significant distress in social, occupational, or other important areas of functioning.
Other Characteristics of Substance Dependence
- Persisting with substance use despite clear evidence of harmful consequences.
- Continued use despite awareness of harm.
Classifications of Substances
- No specific information provided.
Investigations
- Routine investigations (hepatitis, HIV markers, liver, kidney functions).
- Structured and semi-structured interview to confirm diagnosis.
- Investigation to prepare the patient for treatment (ECG, CBC, Chest X-ray).
Substance-Specific Information
Alcohol
- Blood Alcohol Level (BAL) - 0.08g/dl.
- Mild and moderate intoxication symptoms:
- Impaired attention, poor motor coordination.
- Dystharthria, ataxia, nystagmus, slurred speech.
- Prolonged reaction time, flushed face, orthostatic hypotension.
- Hematemesis and stupor.
- Pathological intoxication:
- Excited, psychotic state following minimal consumption in susceptible individuals.
Uncomplicated Alcohol Withdrawal
- Coarse tremors of hands, tongue, eyelids.
- At least one of the following:
- Nausea or vomiting.
- Malaise or weakness.
- Autonomic hyperactivity.
- Anxiety, depressed mood or irritability.
- Transient hallucination or illusions.
- Headache, insomnia.
Opiates
- Patients rarely seek treatment for intoxication.
- Overdose symptoms:
- Respiratory and CNS depression.
- Depression.
- Gastric hypomotility with ileus.
- Non-cardiogenic pulmonary edema.
- Withdrawal symptoms:
- Lacrimation, rhinorrhea.
- Diaphoresis, yawing, sneezing.
- Malaise, irritability, nausea, and vomiting.
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Description
This quiz covers the concept of withdrawal syndrome, also known as abstinence syndrome, which occurs when an individual stops or reduces the use of a substance after prolonged regular use. It is characterized by physical and psychological symptoms.