Prothrombin Time (PT) and INR

Patient Information

• Patient Name: Mukesh Kumar
• The patient is a 27-year-old male.
• The referring doctor is Self

Test Details

• Prothrombin Time (PT) was measured using the nephelometry method.
• Prothrombin Time Result: 18.3 seconds (High), the reference range is 9.1 - 12.1 seconds
• International Normalized Ratio (INR): 1.72 (High), the reference value is less than 1.40.
• Mean Prothrombin Time of Control Plasma (MNPT): 10.8 seconds

Prothrombin Time Test

• Prothrombin Time measures the integrity of the extrinsic pathway
• Assesses the adequacy of critical coagulation factors, including Factor VII
• Used to monitor oral anticoagulation therapy

Oral Anticoagulation Therapy

• Oral anticoagulation therapy lowers levels of multiple vitamin K dependent coagulation factors
• These factors include Factors II, VII, IX, and X
• PT results are expressed as INR to neutralize variability due to different thromboplastin reagents

Increased PT Causes

• Factor deficiencies
• Drugs like Coumarin-type anticoagulants and salicylates
• Severe liver damage, such as poisoning, hepatitis, or cirrhosis
• Hypofibrinogenemia (acquired or inherited)
• Hemorrhagic disease of the newborn
• Poor fat absorption (e.g., obstructive jaundice, fistulas, sprue, steatorrhea, celiac disease, chronic diarrhea)

INR

• Follow-up INR value is more advisable than PT in seconds due to reagent sensitivity
• Recommended INR for patients on oral anticoagulants: 2 - 3
• INR target for mechanical valve replacement and prevention of myocardial infarction: 2.5-3.5
• Anticoagulant therapy should be stopped if the INR is greater than 4.5

General Information

• The diagnostic report was finalized.
• The sample was drawn on February 26, 2025, at 10:04:36.
• The sample was received on February 26, 2025, at 11:45:27.
• The report was generated on February 26, 2025, at 12:56:06.