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Questions and Answers
What triggers vasoconstriction right after tissue injury?
What triggers vasoconstriction right after tissue injury?
Which factor is deficient in Hemophilia A?
Which factor is deficient in Hemophilia A?
What enzymatically converts plasminogen into plasmin?
What enzymatically converts plasminogen into plasmin?
Platelet adhesion is part of which hemostasis system?
Platelet adhesion is part of which hemostasis system?
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Which factor is NOT part of the fibrinogen group in the coagulation system?
Which factor is NOT part of the fibrinogen group in the coagulation system?
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What clears fibrin split products in the fibrinolytic system?
What clears fibrin split products in the fibrinolytic system?
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Which factor is preserved in plasma & serum and undergoes gammacarboxylation for calcium bridge formation?
Which factor is preserved in plasma & serum and undergoes gammacarboxylation for calcium bridge formation?
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What is the main source of Vitamin K that is essential for the synthesis of clotting factors?
What is the main source of Vitamin K that is essential for the synthesis of clotting factors?
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Which of the following diseases can lead to decreased synthesis of factors 5 & 8 due to defective Vitamin K absorption?
Which of the following diseases can lead to decreased synthesis of factors 5 & 8 due to defective Vitamin K absorption?
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What inhibits the activation of factors 5 & 8, causing hypercoagulation?
What inhibits the activation of factors 5 & 8, causing hypercoagulation?
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Which substance mediates vasoconstriction by acting on smooth muscles of the basement membrane during hemostasis?
Which substance mediates vasoconstriction by acting on smooth muscles of the basement membrane during hemostasis?
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What plays a role in forming calcium bridges important for clotting, requiring calcium as a cofactor?
What plays a role in forming calcium bridges important for clotting, requiring calcium as a cofactor?
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What is the primary mechanism of coagulation in vivo?
What is the primary mechanism of coagulation in vivo?
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Which factor is activated upon exposure to a negatively charged surface like glass or kaolin, initiating the contact phase of coagulation?
Which factor is activated upon exposure to a negatively charged surface like glass or kaolin, initiating the contact phase of coagulation?
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What role does tissue plasminogen activator play in hemostasis?
What role does tissue plasminogen activator play in hemostasis?
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What is the enzyme responsible for activating FX in the common pathway?
What is the enzyme responsible for activating FX in the common pathway?
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How is the temporary fibrin clot systematically and gradually dissolved during wound healing?
How is the temporary fibrin clot systematically and gradually dissolved during wound healing?
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Which protein plays a role in both coagulation and fibrinolysis concurrently to restore blood flow?
Which protein plays a role in both coagulation and fibrinolysis concurrently to restore blood flow?
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Study Notes
Hemostasis and Coagulation
- Vasoconstriction is triggered by thromboxane A2 and endothelin right after tissue injury.
- Hemophilia A is deficient in Factor VIII (Anti-hemophilic Factor).
- Tissue plasminogen activator (t-PA) enzymatically converts plasminogen into plasmin.
- Platelet adhesion is part of the primary hemostasis system.
- Factor V is NOT part of the fibrinogen group in the coagulation system.
- Fibrin split products are cleared by the fibrinolytic system.
Vitamin K and Clotting Factors
- Vitamin K is essential for the synthesis of clotting factors, and the main source is dietary.
- Defective Vitamin K absorption due to biliary obstruction or fat malabsorption can lead to decreased synthesis of factors 5 & 8 in diseases like cholestasis.
Regulation of Coagulation
- Antithrombin III inhibits the activation of factors 5 & 8, causing hypercoagulation.
- Endothelin mediates vasoconstriction by acting on smooth muscles of the basement membrane during hemostasis.
- Calcium plays a crucial role in forming calcium bridges important for clotting, requiring calcium as a cofactor.
Coagulation Mechanisms
- The primary mechanism of coagulation in vivo is the extrinsic pathway.
- Factor XII is activated upon exposure to a negatively charged surface like glass or kaolin, initiating the contact phase of coagulation.
- Tissue plasminogen activator plays a role in fibrinolysis, breaking down fibrin clots.
Fibrinolysis and Wound Healing
- The temporary fibrin clot is systematically and gradually dissolved during wound healing through the fibrinolytic pathway.
- Plasminogen activator inhibitor-1 (PAI-1) is the enzyme responsible for activating FX in the common pathway.
- Thrombomodulin plays a role in both coagulation and fibrinolysis concurrently to restore blood flow.
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Description
Test your knowledge on prothrombin and Vitamin K-dependent factors involved in blood clotting. Learn about the preservation of these factors in plasma and serum, the process of gammacarboxylation, and the main dietary sources of Vitamin K.
