18 Questions
What is the main function of the Rossmann Fold motif in proteins?
Promote the binding of cofactors
Which type of interactions play a crucial role in organizing the hydrophobic core of globular proteins?
Hydrophobic interactions
What is the primary purpose of organizing amino acid chemistries into specific microenvironments in a globular protein?
Facilitate enzymatic reactions
In protein structures, which feature combines parallel beta sheets with alpha helices?
Rossmann Fold motif
What term describes a protein feature that contains both hydrophilic and hydrophobic regions?
Amphipathic structure
How does the Rossmann Fold motif relate to the binding of cofactors in proteins?
It positions helices and turns to bind with cofactors.
Which type of protein structure is tightly packed and compact, as opposed to fibrous proteins like collagen?
Alpha helix
What type of interaction between helices is essential for interhelix association to occur in protein structures?
Van der Waals interactions
Which motif is frequently encountered in globular proteins and consists of the sequence aa bb bbbb?
Greek Key motif
What type of interactions are utilized at the helix-helix interface to decrease free energy (DG°) in protein folding?
Van der Waals interactions
In an amphipathic structure of a protein, which part of the structure interacts favorably with water?
Polar region
What feature permits different angles of helices to be adopted in globular protein folding, leading to diverse functions?
Linker length between helices
Why are disulfide bonds important in protein stability?
They create intrachain covalent linkages that increase protein stability
Which of the following is NOT a reason why disulfide bonds are not present in every protein?
Disulfides can form too many hydrophobic interactions
What property of proteins is used to compare their stability by quantifying the melting temperature (Tm)?
Degree of native vs unfolded conformation
In what type of proteins are disulfide bonds mostly found?
Secreted proteins
Which structure in proteins is primarily stabilized by hydrophobic interactions?
Amphipathic structures
What is the significance of breaking only one of the disulfide bonds in a protein like bovine pancreatic trypsin inhibitor?
It decreases protein stability significantly
Test your knowledge on protein structures and enzyme cofactors like nicotinamide adenine dinucleotide (NAD) within the context of Rossman Fold motifs. Learn about the role of Rossmann Fold in binding with cofactors and its supersecondary structure.
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