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Protein Structure and Misfolding Diseases

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Protein Structure and Misfolding Diseases

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Questions and Answers

What is the structural configuration of the polypeptide chain in an α-helix?

Parallel chain

Antiparallel chain

Hydrogen bonding between first and fourth amino acid residues (correct)

Pleated sheet structure

What is the structural arrangement of a β-sheet?

Helical

Accordion-like pleated sheet (correct)

Parallel chain

Antiparallel chain

Which of the following proteins is an example of a β-sheet structure?

Hemoglobin

Keratin (correct)

Prion

Myoglobin

What is the cause of Creutzfeldt-Jakob Disease (CJD)?

Prions Signup and view all the answers

What is the effect of prions on the normal prion protein found in the brain?

Prions cause the normal prion protein to misfold into a β-pleated sheet structure Signup and view all the answers

What is the name given to the simplest level of structural organization in proteins?

Primary structure Signup and view all the answers

What happens to the migration of a protein in an electric field when it is at its isoelectric point?

The protein does not migrate since its net charge is 0 Signup and view all the answers

Which of the following is NOT a type of secondary structure found in proteins?

Quaternary structure Signup and view all the answers

What is the role of chaperone proteins in protein folding?

They assist in the folding and unfolding of the polypeptide to correctly form the tertiary structure Signup and view all the answers

Which type of bond contributes to the stabilization of the tertiary structure of a protein?

All of the above Signup and view all the answers

What is the main cause of Creutzfeldt-Jakob Disease (CJD)?

Both (b) and (c) Signup and view all the answers