Protein Structure and Misfolding Diseases

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Questions and Answers

What is the structural configuration of the polypeptide chain in an α-helix?

  • Parallel chain
  • Antiparallel chain
  • Hydrogen bonding between first and fourth amino acid residues (correct)
  • Pleated sheet structure

What is the structural arrangement of a β-sheet?

  • Helical
  • Accordion-like pleated sheet (correct)
  • Parallel chain
  • Antiparallel chain

Which of the following proteins is an example of a β-sheet structure?

  • Hemoglobin
  • Keratin (correct)
  • Prion
  • Myoglobin

What is the cause of Creutzfeldt-Jakob Disease (CJD)?

<p>Prions (B)</p> Signup and view all the answers

What is the effect of prions on the normal prion protein found in the brain?

<p>Prions cause the normal prion protein to misfold into a β-pleated sheet structure (D)</p> Signup and view all the answers

What is the name given to the simplest level of structural organization in proteins?

<p>Primary structure (D)</p> Signup and view all the answers

What happens to the migration of a protein in an electric field when it is at its isoelectric point?

<p>The protein does not migrate since its net charge is 0 (B)</p> Signup and view all the answers

Which of the following is NOT a type of secondary structure found in proteins?

<p>Quaternary structure (A)</p> Signup and view all the answers

What is the role of chaperone proteins in protein folding?

<p>They assist in the folding and unfolding of the polypeptide to correctly form the tertiary structure (A)</p> Signup and view all the answers

Which type of bond contributes to the stabilization of the tertiary structure of a protein?

<p>All of the above (D)</p> Signup and view all the answers

What is the main cause of Creutzfeldt-Jakob Disease (CJD)?

<p>Both (b) and (c) (B)</p> Signup and view all the answers

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