Protein Stabilization and Substances Quiz

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Questions and Answers

What role do substances like sugar and glycine play in stabilizing proteins such as human growth hormone?

Acting as inhibitors to prevent protein denaturation
Acting as catalysts to speed up protein folding
Acting as preservatives to prevent protein degradation
Acting as bulking agents and stabilizers due to their interaction with water (correct)

Why is it recommended to refrigerate reconstituted human growth hormone (hGH) rather than freeze it?

Refrigeration slows down the degradation of hGH
Freezing can lead to the formation of crystals, which destabilize hGH
Refrigeration allows for better interaction between hGH and stabilizing substances
Freezing can lead to the formation of ice, which highly concentrates the remaining liquid (correct)

What is the purpose of placing amorphous substances like sugars in a glassy state?

To enhance the reactivity of the substances with water molecules
To act as a rigid glass, trapping molecules including proteins and preventing their movement (correct)
To facilitate the crystallization of the substances for better stability
To increase the solubility of the substances in liquid protein formulations

Why is glycine identified as a stabilizer in the presence of mannitol?

<p>It allows for interactions, such as hydrogen bonding, between glycine and mannitol, contributing to the stabilization of proteins (A)</p> Signup and view all the answers

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