4 Questions
What role do substances like sugar and glycine play in stabilizing proteins such as human growth hormone?
Acting as bulking agents and stabilizers due to their interaction with water
Why is it recommended to refrigerate reconstituted human growth hormone (hGH) rather than freeze it?
Freezing can lead to the formation of ice, which highly concentrates the remaining liquid
What is the purpose of placing amorphous substances like sugars in a glassy state?
To act as a rigid glass, trapping molecules including proteins and preventing their movement
Why is glycine identified as a stabilizer in the presence of mannitol?
It allows for interactions, such as hydrogen bonding, between glycine and mannitol, contributing to the stabilization of proteins
Take the "Protein Stabilization and Substances Quiz" to test your knowledge on how substances like sugar and glycine stabilize proteins such as human growth hormone. Explore the role of water in maintaining protein structure and the potential consequences of protein collapse in dry/dehydrated states.
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