5 Questions
What is the process that often involves the formation of covalent bonds in the maturation of proteins into their final state?
Posttranslational modification
What are the larger precursors of polypeptides called?
Proproteins
What do the leader sequences in proproteins target?
A particular organelle or facilitate passage through a membrane
What ensures that the potential harmful activity of a protein remains inhibited until it reaches its final destination?
Other segments
What may covalent modifications add to a protein?
New chemical functionalities
Study Notes
Post-Translational Modifications of Proteins
- The process that often involves the formation of covalent bonds in the maturation of proteins into their final state is post-translational modification.
Protein Precursors
- The larger precursors of polypeptides are called proproteins.
Leader Sequences
- The leader sequences in proproteins target specific organelles or locations within the cell.
Protein Regulation
- The potential harmful activity of a protein remains inhibited until it reaches its final destination, ensured by the proregion or prosequence.
Covalent Modifications
- Covalent modifications may add carbohydrate molecules (glycosylation), lipids (lipidation), or phosphate groups (phosphorylation) to a protein, altering its function or localization.
Test your knowledge on the maturation process of proteins, including the formation of covalent bonds and post-translational modifications. Explore the synthesis of polypeptides from larger precursors and the role of leader sequences and membrane passage.
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