Protein-Ligand Binding and Dissociation Constants Quiz
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Questions and Answers

What is the physiologically important role of selective enhancement of affinity in globins?

It helps prevent poisoning by CO generated from metabolism and our industrial-age environment.

How does the binding of oxygen to the heme in myoglobin depend on the protein structure?

It depends on molecular motions or 'breathing' in the protein structure.

Why is it important for the protein structure to have transient cavities?

Transient cavities allow oxygen to move in and out of the heme pocket.

What role does the distal His residue play in myoglobin?

<p>The distal His acts as a gate to control access to one major pocket near the heme iron.</p> Signup and view all the answers

How does the pocket near the heme iron in myoglobin open and close?

<p>The pocket opens and closes through the rotation of the distal His residue on a nanosecond time scale.</p> Signup and view all the answers

What is the main function of hemoglobin in animals?

<p>Hemoglobin transports oxygen in blood.</p> Signup and view all the answers

What is the size and shape of normal human erythrocytes?

<p>Normal human erythrocytes are small, biconcave disks.</p> Signup and view all the answers

What are precursor stem cells for erythrocytes called?

<p>Precursor stem cells for erythrocytes are called hemocytoblasts.</p> Signup and view all the answers

What happens to the organelles of daughter cells during the maturation process of erythrocytes?

<p>Daughter cells produce large amounts of hemoglobin and then lose their organelles.</p> Signup and view all the answers

How is most of the oxygen carried by whole blood in animals transported?

<p>Most of the oxygen carried by whole blood in animals is bound and transported by hemoglobin in erythrocytes.</p> Signup and view all the answers

Which of the following is true about the selective enhancement of affinity in globins?

<p>It helps prevent poisoning by the CO that is generated in large amounts by our industrial-age environment.</p> Signup and view all the answers

What is the role of the distal His residue in myoglobin?

<p>It controls access to one major pocket near the heme iron.</p> Signup and view all the answers

What is the main function of hemoglobin in animals?

<p>Transporting oxygen in the blood.</p> Signup and view all the answers

Why is it important for the protein structure to have transient cavities?

<p>To allow oxygen to move from the surrounding solution to the ligand-binding site.</p> Signup and view all the answers

How does the pocket near the heme iron in myoglobin open and close?

<p>By the rotation of the distal His residue.</p> Signup and view all the answers

What happens to the organelles of daughter cells during the maturation process of erythrocytes?

<p>They are lost.</p> Signup and view all the answers

What is the size and shape of normal human erythrocytes?

<p>Small and biconcave disks.</p> Signup and view all the answers

How is most of the oxygen carried by whole blood in animals transported?

<p>By hemoglobin in erythrocytes.</p> Signup and view all the answers

What is the physiological importance of the selective enhancement of affinity in globins?

<p>It helps prevent poisoning by the CO that is generated in small amounts from metabolism and that is sometimes generated in larger amounts by our industrial-age environment.</p> Signup and view all the answers

How does the binding of oxygen to the heme in myoglobin depend on the protein structure?

<p>It depends on molecular motions, or 'breathing,' in the protein structure.</p> Signup and view all the answers

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