Protein Folding and Denaturation
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Questions and Answers

What is the central metal ion in the heme molecule?

  • Mg2+
  • Zn2+
  • Fe2+ (correct)
  • Ca2+
  • What is the function of the heme group in hemoglobin and myoglobin?

  • To stabilize the polypeptide chain
  • To reversibly bind oxygen (correct)
  • To facilitate protein denaturation
  • To catalyze peptide bond formation
  • What is the prosthetic group tightly bound to hem proteins?

  • NAD+
  • Heme (correct)
  • FAD
  • Coenzyme A
  • What is the structure of myoglobin?

    <p>A compact molecule with α-helix stretches</p> Signup and view all the answers

    What is the function of myoglobin?

    <p>To function as a reservoir for oxygen</p> Signup and view all the answers

    What is the coordination of the heme Fe++?

    <p>One bond to the side chain of a histidine residue and one available to bind oxygen</p> Signup and view all the answers

    What is the central element of the porphyrin ring in myoglobin?

    <p>Iron</p> Signup and view all the answers

    What is the function of the distal histidine in myoglobin?

    <p>Helps stabilize the binding of oxygen</p> Signup and view all the answers

    What is the structure of hemoglobin A?

    <p>Four polypeptide chains: two α chains and two β chains</p> Signup and view all the answers

    What is the difference between the T form and the R form of hemoglobin?

    <p>T form has low oxygen affinity, R form has high oxygen affinity</p> Signup and view all the answers

    What is the significance of the oxygen dissociation curve for myoglobin?

    <p>It shows a hyperbolic shape</p> Signup and view all the answers

    What is the difference between the oxygen binding affinity of myoglobin and hemoglobin?

    <p>Myoglobin has higher oxygen binding affinity than hemoglobin</p> Signup and view all the answers

    Which type of bond stabilizes the α-helix?

    <p>Intra chain hydrogen bonds</p> Signup and view all the answers

    What is the characteristic feature of a β-sheet?

    <p>Segments of polypeptide chains running alongside each other</p> Signup and view all the answers

    In a β-sheet, what type of bonds are formed between different segments of polypeptide?

    <p>Hydrogen bonds</p> Signup and view all the answers

    What is the name given to a simple structural motif involving β-sheets?

    <p>β-Bend (β-hairpin)</p> Signup and view all the answers

    In an antiparallel β-sheet, what is the arrangement of the N-terminal and C-terminal ends of the β-strands?

    <p>They are alternating</p> Signup and view all the answers

    What is the typical composition of a β-Bend?

    <p>Four amino acids, including proline and glycine</p> Signup and view all the answers

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