Protein Folding 101
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Questions and Answers

Which factor is the main thermodynamic force driving protein folding?

  • Minimization of solvent-accessible surface area
  • Hydrophobic effect (correct)
  • Maximization of intraprotein hydrogen bonds
  • Maximization of van der Waals interactions

What is the enthalpic contribution to protein folding provided by?

  • Hydrophobic effect
  • Hydrogen bonding
  • Van der Waals interactions (correct)
  • Ionic interactions

What is the entropic contribution to protein folding?

  • Maximization of van der Waals interactions
  • Maximization of intraprotein hydrogen bonds
  • Hydrophobic effect
  • Minimization of solvent-accessible surface area (correct)

What is required for the burial of hydrophobic R groups away from water?

<p>At least 2 interacting secondary elements (A)</p> Signup and view all the answers

What guides correct folding rather than driving it thermodynamically?

<p>Hydrogen bonding (D)</p> Signup and view all the answers

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