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Protein Folding 101

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Questions and Answers

Which factor is the main thermodynamic force driving protein folding?

Minimization of solvent-accessible surface area

Hydrophobic effect (correct)

Maximization of intraprotein hydrogen bonds

Maximization of van der Waals interactions

What is the enthalpic contribution to protein folding provided by?

Hydrophobic effect

Hydrogen bonding

Van der Waals interactions (correct)

Ionic interactions

What is the entropic contribution to protein folding?

Maximization of van der Waals interactions

Maximization of intraprotein hydrogen bonds

Hydrophobic effect

Minimization of solvent-accessible surface area (correct)

What is required for the burial of hydrophobic R groups away from water?

<p>At least 2 interacting secondary elements</p> Signup and view all the answers

What guides correct folding rather than driving it thermodynamically?

<p>Hydrogen bonding</p> Signup and view all the answers