Protein Biopharmaceuticals
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Questions and Answers

How is absorption from the injection site usually characterized for proteins?

  • Variable
  • Slow (correct)
  • Rapid
  • Intermittent
  • What is the bioavailability of proteins compared to many small molecule drugs?

  • 10%–20%
  • 80%–100% (correct)
  • 30%–40%
  • 50%–60%
  • How are protein biopharmaceuticals removed from the body?

  • Converted to small molecules
  • Not removed by metabolism (correct)
  • Metabolized quickly
  • Excreted unchanged
  • What is the typical half-life of proteins in the circulation?

    <p>Long</p> Signup and view all the answers

    What type of dose–response relationship is observed for human recombinant erythropoietin?

    <p>Bell-shaped</p> Signup and view all the answers

    What is the estimated worth of the gene therapy sector by 2028?

    <p>US$10–20 billion</p> Signup and view all the answers

    Which type of diseases are gene therapies primarily targeting?

    <p>Rare genetic and monogenic diseases</p> Signup and view all the answers

    What are the two main gene therapy strategies mentioned in the text?

    <p>In vivo and ex vivo</p> Signup and view all the answers

    What is the primary reason for the conventional treatment of certain disorders being far from ideal?

    <p>Large genetic component of the disorders</p> Signup and view all the answers

    What was the key realization that emerged following the molecular biology revolution in the 1980s?

    <p>Potential of genetic manipulation</p> Signup and view all the answers

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