10 Questions
How is absorption from the injection site usually characterized for proteins?
Slow
What is the bioavailability of proteins compared to many small molecule drugs?
80%–100%
How are protein biopharmaceuticals removed from the body?
Not removed by metabolism
What is the typical half-life of proteins in the circulation?
Long
What type of dose–response relationship is observed for human recombinant erythropoietin?
Bell-shaped
What is the estimated worth of the gene therapy sector by 2028?
US$10–20 billion
Which type of diseases are gene therapies primarily targeting?
Rare genetic and monogenic diseases
What are the two main gene therapy strategies mentioned in the text?
In vivo and ex vivo
What is the primary reason for the conventional treatment of certain disorders being far from ideal?
Large genetic component of the disorders
What was the key realization that emerged following the molecular biology revolution in the 1980s?
Potential of genetic manipulation
Test your knowledge of the pharmacology of protein biopharmaceuticals with this quiz. Explore the differences in nature and size compared to conventional drugs, and their implications for pharmacokinetic properties. Delve into topics such as bioavailability and administration routes.
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