Protein Biopharmaceuticals
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Questions and Answers

How is absorption from the injection site usually characterized for proteins?

  • Variable
  • Slow (correct)
  • Rapid
  • Intermittent

What is the bioavailability of proteins compared to many small molecule drugs?

  • 10%–20%
  • 80%–100% (correct)
  • 30%–40%
  • 50%–60%

How are protein biopharmaceuticals removed from the body?

  • Converted to small molecules
  • Not removed by metabolism (correct)
  • Metabolized quickly
  • Excreted unchanged

What is the typical half-life of proteins in the circulation?

<p>Long (C)</p> Signup and view all the answers

What type of dose–response relationship is observed for human recombinant erythropoietin?

<p>Bell-shaped (C)</p> Signup and view all the answers

What is the estimated worth of the gene therapy sector by 2028?

<p>US$10–20 billion (D)</p> Signup and view all the answers

Which type of diseases are gene therapies primarily targeting?

<p>Rare genetic and monogenic diseases (B)</p> Signup and view all the answers

What are the two main gene therapy strategies mentioned in the text?

<p>In vivo and ex vivo (D)</p> Signup and view all the answers

What is the primary reason for the conventional treatment of certain disorders being far from ideal?

<p>Large genetic component of the disorders (B)</p> Signup and view all the answers

What was the key realization that emerged following the molecular biology revolution in the 1980s?

<p>Potential of genetic manipulation (D)</p> Signup and view all the answers

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