Propylthiouracil Use and Monitoring Quiz

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Questions and Answers

What is the duration of action for propylthiouracil?

1 to 2 hours (correct)

12 to 24 hours

4 to 6 hours

48 to 72 hours

How does propylthiouracil act in the body?

By promoting production of thyroid hormones and peripheral conversion of T3 to T4

By inhibiting production of thyroid hormones and peripheral conversion of T4 to T3 (correct)

By increasing the metabolism of thyroid hormones

By enhancing release of thyroid hormones previously produced and stored

When do therapeutic effects of propylthiouracil typically occur?

Immediately after administration

After 48 hours of administration

Within 30 minutes of administration

Several days or weeks after the stored hormones have been used (correct)

How is propylthiouracil metabolized in the body?

In the liver and excreted in urine Signup and view all the answers

For what purpose may propylthiouracil be used in the treatment of hyperthyroidism?

As part of the preoperative preparation for thyroidectomy Signup and view all the answers

What is the peak plasma levels occurrence time for propylthiouracil?

Within 30 minutes Signup and view all the answers

How often must propylthiouracil be given due to its relatively short duration of action?

Every 8 hours Signup and view all the answers

What effect does treatment of hyperthyroidism have on the rate of body metabolism?

Changes the rate of body metabolism Signup and view all the answers

What does propylthiouracil not interfere with in terms of thyroid hormones?

Release of thyroid hormones previously produced and stored Signup and view all the answers

In which organ is propylthiouracil metabolized?

Liver Signup and view all the answers

What is the recommended action for women of childbearing age before beginning methimazole during the first trimester?

Have a pregnancy test Signup and view all the answers

Which drug is used to treat thyrotoxic crisis and to decrease the size and vascularity of the thyroid gland before thyroidectomy?

Lugol solution Signup and view all the answers

What is the primary disadvantage of sodium iodide 131I (Hicon) therapy?

Hypothyroidism Signup and view all the answers

What is the role of propranolol (Inderal) in treating hyperthyroidism?

Blocking beta-adrenergic receptors Signup and view all the answers

What is the primary risk associated with radioactive iodine therapy?

Hypothyroidism Signup and view all the answers

What is the action of methimazole (Tapazole) in terms of thyroid hormones?

Inhibits release of thyroid hormones Signup and view all the answers

What is the role of Lugol solution in the treatment of hyperthyroidism?

Inhibits thyroid hormone synthesis Signup and view all the answers

What is the effect of radioactive iodine therapy on thyroid tissue?

Causes destruction of thyroid tissue Signup and view all the answers

When should propranolol be tapered and discontinued in patients with hyperthyroidism?

When hyperthyroid symptoms are controlled Signup and view all the answers

What is the primary purpose of using strong iodine solution (Lugol solution) and saturated solution of potassium iodide (SSKI) in the treatment of hyperthyroidism?

To inhibit thyroid hormone synthesis Signup and view all the answers

What is a key consideration when a patient becomes euthyroid while taking propylthiouracil?

Evaluation and potential dose reduction of all medications to avoid adverse effects Signup and view all the answers

Why is radioactive iodine often preferred over propylthiouracil in hyperthyroidism treatment?

It has fewer adverse effects Signup and view all the answers

What should healthcare providers closely monitor for in patients who have undergone hyperthyroidism treatment?

Hypothyroidism, which typically develops within a year after treatment Signup and view all the answers

What has the FDA issued a black box warning for regarding propylthiouracil?

Risk of severe liver injury or acute liver failure within 6 months of treatment Signup and view all the answers

Which of the following is NOT listed as an adverse effect of propylthiouracil?

Increased heart rate Signup and view all the answers

What is a contraindication for propylthiouracil use?

Known hypersensitivity reactions to the medication Signup and view all the answers

What is a potential drug interaction with propylthiouracil that may lead to hypothyroidism?

Amiodarone Signup and view all the answers

How should patients take propylthiouracil?

Around the clock in evenly divided doses Signup and view all the answers

What should nurses assess for in patients taking propylthiouracil?

Adverse effects, including heart and lung function, CNS depression, and signs of agranulocytosis Signup and view all the answers

What should patient teaching for propylthiouracil include?

Information on thyroid and liver function tests, dietary restrictions, regular drug dosing, reporting adverse effects, and avoiding certain over-the-counter drugs Signup and view all the answers

Study Notes

Propylthiouracil Use and Monitoring: Key Points

When a patient becomes euthyroid, drug metabolism decreases, requiring evaluation and potential dose reduction of all medications to avoid adverse effects.
Propylthiouracil (or methimazole) may be useful in older adults, while radioactive iodine is often preferred for its fewer adverse effects.
Patients should be closely monitored for hypothyroidism, which typically develops within a year after hyperthyroidism treatment.
The FDA has issued a black box warning for propylthiouracil due to the risk of severe liver injury or acute liver failure within 6 months of treatment.
Adverse effects of propylthiouracil include signs of hypothyroidism, hematologic effects, dermatologic effects, CNS effects, gastrointestinal effects, and other reported effects.
Contraindications for propylthiouracil include known hypersensitivity reactions to the medication.
Clinical symptoms, diagnosis, and prevention of associated vasculitis in the intensive care setting have been studied, with emphasis on screening and aggressive wound care.
Propylthiouracil may increase the effect of anticoagulants, interact with amiodarone, potassium iodide, sodium iodide, and lithium, leading to hypothyroidism.
Patients should take propylthiouracil around the clock in evenly divided doses and be assessed for therapeutic effects, which may take 1 to 2 weeks to appear.
Nurses should assess for adverse effects, including heart and lung function, CNS depression, and signs of agranulocytosis, and provide patient teaching on signs of acute liver failure.
Patient teaching guidelines for propylthiouracil include information on thyroid and liver function tests, dietary restrictions, regular drug dosing, reporting adverse effects, and avoiding certain over-the-counter drugs.
Patients are advised to monitor their pulse and weight, report specific symptoms to their prescriber, and consult a healthcare provider before taking over-the-counter drugs.

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Description

Test your knowledge of propylthiouracil use and monitoring with this quiz. Explore key points such as adverse effects, contraindications, monitoring for hypothyroidism, drug interactions, patient teaching, and more. Stay updated on essential information for safe and effective patient care.