Podcast
Questions and Answers
What is the duration of action for propylthiouracil?
What is the duration of action for propylthiouracil?
- 1 to 2 hours (correct)
- 12 to 24 hours
- 4 to 6 hours
- 48 to 72 hours
How does propylthiouracil act in the body?
How does propylthiouracil act in the body?
- By promoting production of thyroid hormones and peripheral conversion of T3 to T4
- By inhibiting production of thyroid hormones and peripheral conversion of T4 to T3 (correct)
- By increasing the metabolism of thyroid hormones
- By enhancing release of thyroid hormones previously produced and stored
When do therapeutic effects of propylthiouracil typically occur?
When do therapeutic effects of propylthiouracil typically occur?
- Immediately after administration
- After 48 hours of administration
- Within 30 minutes of administration
- Several days or weeks after the stored hormones have been used (correct)
How is propylthiouracil metabolized in the body?
How is propylthiouracil metabolized in the body?
For what purpose may propylthiouracil be used in the treatment of hyperthyroidism?
For what purpose may propylthiouracil be used in the treatment of hyperthyroidism?
What is the peak plasma levels occurrence time for propylthiouracil?
What is the peak plasma levels occurrence time for propylthiouracil?
How often must propylthiouracil be given due to its relatively short duration of action?
How often must propylthiouracil be given due to its relatively short duration of action?
What effect does treatment of hyperthyroidism have on the rate of body metabolism?
What effect does treatment of hyperthyroidism have on the rate of body metabolism?
What does propylthiouracil not interfere with in terms of thyroid hormones?
What does propylthiouracil not interfere with in terms of thyroid hormones?
In which organ is propylthiouracil metabolized?
In which organ is propylthiouracil metabolized?
What is the recommended action for women of childbearing age before beginning methimazole during the first trimester?
What is the recommended action for women of childbearing age before beginning methimazole during the first trimester?
Which drug is used to treat thyrotoxic crisis and to decrease the size and vascularity of the thyroid gland before thyroidectomy?
Which drug is used to treat thyrotoxic crisis and to decrease the size and vascularity of the thyroid gland before thyroidectomy?
What is the primary disadvantage of sodium iodide 131I (Hicon) therapy?
What is the primary disadvantage of sodium iodide 131I (Hicon) therapy?
What is the role of propranolol (Inderal) in treating hyperthyroidism?
What is the role of propranolol (Inderal) in treating hyperthyroidism?
What is the primary risk associated with radioactive iodine therapy?
What is the primary risk associated with radioactive iodine therapy?
What is the action of methimazole (Tapazole) in terms of thyroid hormones?
What is the action of methimazole (Tapazole) in terms of thyroid hormones?
What is the role of Lugol solution in the treatment of hyperthyroidism?
What is the role of Lugol solution in the treatment of hyperthyroidism?
What is the effect of radioactive iodine therapy on thyroid tissue?
What is the effect of radioactive iodine therapy on thyroid tissue?
When should propranolol be tapered and discontinued in patients with hyperthyroidism?
When should propranolol be tapered and discontinued in patients with hyperthyroidism?
What is the primary purpose of using strong iodine solution (Lugol solution) and saturated solution of potassium iodide (SSKI) in the treatment of hyperthyroidism?
What is the primary purpose of using strong iodine solution (Lugol solution) and saturated solution of potassium iodide (SSKI) in the treatment of hyperthyroidism?
What is a key consideration when a patient becomes euthyroid while taking propylthiouracil?
What is a key consideration when a patient becomes euthyroid while taking propylthiouracil?
Why is radioactive iodine often preferred over propylthiouracil in hyperthyroidism treatment?
Why is radioactive iodine often preferred over propylthiouracil in hyperthyroidism treatment?
What should healthcare providers closely monitor for in patients who have undergone hyperthyroidism treatment?
What should healthcare providers closely monitor for in patients who have undergone hyperthyroidism treatment?
What has the FDA issued a black box warning for regarding propylthiouracil?
What has the FDA issued a black box warning for regarding propylthiouracil?
Which of the following is NOT listed as an adverse effect of propylthiouracil?
Which of the following is NOT listed as an adverse effect of propylthiouracil?
What is a contraindication for propylthiouracil use?
What is a contraindication for propylthiouracil use?
What is a potential drug interaction with propylthiouracil that may lead to hypothyroidism?
What is a potential drug interaction with propylthiouracil that may lead to hypothyroidism?
How should patients take propylthiouracil?
How should patients take propylthiouracil?
What should nurses assess for in patients taking propylthiouracil?
What should nurses assess for in patients taking propylthiouracil?
What should patient teaching for propylthiouracil include?
What should patient teaching for propylthiouracil include?
Study Notes
Propylthiouracil Use and Monitoring: Key Points
- When a patient becomes euthyroid, drug metabolism decreases, requiring evaluation and potential dose reduction of all medications to avoid adverse effects.
- Propylthiouracil (or methimazole) may be useful in older adults, while radioactive iodine is often preferred for its fewer adverse effects.
- Patients should be closely monitored for hypothyroidism, which typically develops within a year after hyperthyroidism treatment.
- The FDA has issued a black box warning for propylthiouracil due to the risk of severe liver injury or acute liver failure within 6 months of treatment.
- Adverse effects of propylthiouracil include signs of hypothyroidism, hematologic effects, dermatologic effects, CNS effects, gastrointestinal effects, and other reported effects.
- Contraindications for propylthiouracil include known hypersensitivity reactions to the medication.
- Clinical symptoms, diagnosis, and prevention of associated vasculitis in the intensive care setting have been studied, with emphasis on screening and aggressive wound care.
- Propylthiouracil may increase the effect of anticoagulants, interact with amiodarone, potassium iodide, sodium iodide, and lithium, leading to hypothyroidism.
- Patients should take propylthiouracil around the clock in evenly divided doses and be assessed for therapeutic effects, which may take 1 to 2 weeks to appear.
- Nurses should assess for adverse effects, including heart and lung function, CNS depression, and signs of agranulocytosis, and provide patient teaching on signs of acute liver failure.
- Patient teaching guidelines for propylthiouracil include information on thyroid and liver function tests, dietary restrictions, regular drug dosing, reporting adverse effects, and avoiding certain over-the-counter drugs.
- Patients are advised to monitor their pulse and weight, report specific symptoms to their prescriber, and consult a healthcare provider before taking over-the-counter drugs.
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Description
Test your knowledge of propylthiouracil use and monitoring with this quiz. Explore key points such as adverse effects, contraindications, monitoring for hypothyroidism, drug interactions, patient teaching, and more. Stay updated on essential information for safe and effective patient care.
