18 Questions
What is the primary mechanism of action of iodine in the treatment of hyperthyroidism?
Inhibition of TPO
Which solution contains 50 mg of iodine per drop?
Potassium iodide saturated solution (KISS)
Why is propylthiouracil preferred over methimazole in the acute treatment of thyroid storm?
Inhibits tissue 5`-deiodinase
What is the adult dose of iodine every 24 hours as directed by public health officials?
130 mg
Which thyroid disorder is primarily treated with iodine and iodide solutions?
Graves' disease
What is the essential chemical group for the anti-thyroid activity of thiourylenes and thionamides?
$S=C–N$ group
What can cause hypothyroidism by increasing plasma protein binding of T4?
Estrogens (oral contraceptives)
How does Amiodarone affect thyroid function in individuals with mild to moderate iodine deficiency?
Stimulates NIS-dependent iodine uptake causing hyperthyroidism
Which deiodinase enzyme accounts is responsible for converting T4 to T3 individuals?
Dio2
In what state is Dio1 upregulated and Dio2 downregulated?
Hyperthyroidism
What drug inhibits Dio1, a plasma membrane protein involved in metabolic activation of thyroid hormones?
Propylthiouracil
Which drug decreases thyroid hormone secretion and can cause hypothyroidism?
Lithium
Which drug is preferred for the treatment of Graves' disease in regular cases?
Methimazole
What is the reason for a delayed full clinical response when using methimazole or propylthiouracil?
The long half-life of T4 and large hormone stores in the thyroid gland
Which drug is safer to use in the first trimester of pregnancy for hyperthyroidism?
Propylthiouracil
Which drug can cause liver failure in pregnant hyperthyroid patients?
Propylthiouracil
Which drug can decrease many signs and symptoms of hyperthyroidism without affecting thyroid function?
β-blockers without intrinsic sympathomimetic activity
Which drug can partially block tissue 5'-deiodinase inhibition and reduce T4 to T3 conversion?
Non-selective agents without ISA
Learn about the drug of choice for regular Graves' disease treatment, methimazole, and its advantages over propylthiouracil. Understand the mechanism of action, time to achieve full clinical response, and potential adverse effects.
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