Podcast
Questions and Answers
What is the primary mechanism of action of iodine in the treatment of hyperthyroidism?
What is the primary mechanism of action of iodine in the treatment of hyperthyroidism?
- Inhibition of TPO (correct)
- Inhibition of tissue 5`-deiodinase
- Enhancement of TG-bound Tyr residues iodination
- Inhibition of NIS
Which solution contains 50 mg of iodine per drop?
Which solution contains 50 mg of iodine per drop?
- Thiourylenes solution
- Potassium iodide saturated solution (KISS) (correct)
- Strong iodine solution (“Lugol” solution)
- Thionamides solution
Why is propylthiouracil preferred over methimazole in the acute treatment of thyroid storm?
Why is propylthiouracil preferred over methimazole in the acute treatment of thyroid storm?
- Inhibits tissue 5`-deiodinase (correct)
- Enhances de-iodination of T4 to T3
- Has a different chemical structure than methimazole
- Acts slower than methimazole
What is the adult dose of iodine every 24 hours as directed by public health officials?
What is the adult dose of iodine every 24 hours as directed by public health officials?
Which thyroid disorder is primarily treated with iodine and iodide solutions?
Which thyroid disorder is primarily treated with iodine and iodide solutions?
What is the essential chemical group for the anti-thyroid activity of thiourylenes and thionamides?
What is the essential chemical group for the anti-thyroid activity of thiourylenes and thionamides?
What can cause hypothyroidism by increasing plasma protein binding of T4?
What can cause hypothyroidism by increasing plasma protein binding of T4?
How does Amiodarone affect thyroid function in individuals with mild to moderate iodine deficiency?
How does Amiodarone affect thyroid function in individuals with mild to moderate iodine deficiency?
Which deiodinase enzyme accounts is responsible for converting T4 to T3 individuals?
Which deiodinase enzyme accounts is responsible for converting T4 to T3 individuals?
In what state is Dio1 upregulated and Dio2 downregulated?
In what state is Dio1 upregulated and Dio2 downregulated?
What drug inhibits Dio1, a plasma membrane protein involved in metabolic activation of thyroid hormones?
What drug inhibits Dio1, a plasma membrane protein involved in metabolic activation of thyroid hormones?
Which drug decreases thyroid hormone secretion and can cause hypothyroidism?
Which drug decreases thyroid hormone secretion and can cause hypothyroidism?
Which drug is preferred for the treatment of Graves' disease in regular cases?
Which drug is preferred for the treatment of Graves' disease in regular cases?
What is the reason for a delayed full clinical response when using methimazole or propylthiouracil?
What is the reason for a delayed full clinical response when using methimazole or propylthiouracil?
Which drug is safer to use in the first trimester of pregnancy for hyperthyroidism?
Which drug is safer to use in the first trimester of pregnancy for hyperthyroidism?
Which drug can cause liver failure in pregnant hyperthyroid patients?
Which drug can cause liver failure in pregnant hyperthyroid patients?
Which drug can decrease many signs and symptoms of hyperthyroidism without affecting thyroid function?
Which drug can decrease many signs and symptoms of hyperthyroidism without affecting thyroid function?
Which drug can partially block tissue 5'-deiodinase inhibition and reduce T4 to T3 conversion?
Which drug can partially block tissue 5'-deiodinase inhibition and reduce T4 to T3 conversion?
