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Questions and Answers
What is the primary goal of radioactive iodine therapy (131I)?
What is the primary goal of radioactive iodine therapy (131I)?
- To stimulate the production of thyroid hormones for long-term balance
- To eliminate the hyperthyroid state with the administration of sufficient radiation in a single dose (correct)
- To prevent the synthesis of thyroid hormones using a series of radiation doses
- To reduce the size of the thyroid gland through continuous low-dose radiation
Why is radioactive iodine therapy contraindicated during pregnancy?
Why is radioactive iodine therapy contraindicated during pregnancy?
- Because it leads to increased fertility and risk of multiple pregnancies
- Because it causes allergic reactions in pregnant women
- Because it reduces the effectiveness of prenatal vitamins
- Because it crosses the placenta and can affect the fetus (correct)
What should women of childbearing age be advised to do before receiving radioactive iodine therapy?
What should women of childbearing age be advised to do before receiving radioactive iodine therapy?
- Undergo a series of fertility treatments
- Take a pregnancy test 48 hours before administration of radioactive iodine (correct)
- Start taking prenatal vitamins 6 weeks before treatment
- Avoid consuming iodine-rich foods for 6 months before treatment
Where does almost all of the iodine that enters and is retained in the body become concentrated?
Where does almost all of the iodine that enters and is retained in the body become concentrated?
What is the purpose of radioactive iodine in the treatment of hyperthyroidism?
What is the purpose of radioactive iodine in the treatment of hyperthyroidism?
What can be the initial effect of an ablative dose of radioactive iodine?
What can be the initial effect of an ablative dose of radioactive iodine?
What should patients treated with radioactive iodine be observed for?
What should patients treated with radioactive iodine be observed for?
What are beta-blockers used for in the context of hyperthyroidism treatment?
What are beta-blockers used for in the context of hyperthyroidism treatment?
When is thyroid hormone replacement started after stopping antithyroid medications?
When is thyroid hormone replacement started after stopping antithyroid medications?
What is the principal test measured following treatment with radioactive iodine?
What is the principal test measured following treatment with radioactive iodine?
What should patients treated with radioactive iodine be informed about?
What should patients treated with radioactive iodine be informed about?
What is the mechanism of action of antithyroid medications?
What is the mechanism of action of antithyroid medications?
Which are the most commonly used antithyroid drugs in the United States?
Which are the most commonly used antithyroid drugs in the United States?
When should antithyroid medications be taken?
When should antithyroid medications be taken?
What is recommended for hyperthyroid pregnant patients during the first trimester?
What is recommended for hyperthyroid pregnant patients during the first trimester?
Why is methimazole recommended for the remainder of pregnancy and breastfeeding?
Why is methimazole recommended for the remainder of pregnancy and breastfeeding?
What is the clinical use of propylthiouracil?
What is the clinical use of propylthiouracil?
How is propylthiouracil metabolized in the body?
How is propylthiouracil metabolized in the body?
What is the BLACK BOX WARNING for propylthiouracil?
What is the BLACK BOX WARNING for propylthiouracil?
When is propylthiouracil used in the treatment of hyperthyroidism?
When is propylthiouracil used in the treatment of hyperthyroidism?
What adverse effect may be associated with propylthiouracil use in older adults?
What adverse effect may be associated with propylthiouracil use in older adults?
What is the only contraindication to propylthiouracil?
What is the only contraindication to propylthiouracil?
Which clinical evidence suggests a potential association with propylthiouracil?
Which clinical evidence suggests a potential association with propylthiouracil?
What should be monitored when propylthiouracil interacts with anticoagulants?
What should be monitored when propylthiouracil interacts with anticoagulants?
What should be assessed in patients receiving propylthiouracil?
What should be assessed in patients receiving propylthiouracil?
How long does it take for the onset of therapeutic effects of propylthiouracil?
How long does it take for the onset of therapeutic effects of propylthiouracil?
What is the preferred alternative to propylthiouracil in older adults?
What is the preferred alternative to propylthiouracil in older adults?
What is the plasma half-life of propylthiouracil?
What is the plasma half-life of propylthiouracil?
What should patients be instructed to do with antithyroid drugs?
What should patients be instructed to do with antithyroid drugs?
Which drug is recommended in all patients with symptomatic hyperthyroidism, particularly in older adults with cardiovascular conditions?
Which drug is recommended in all patients with symptomatic hyperthyroidism, particularly in older adults with cardiovascular conditions?
What are strong iodine solution and saturated solution of potassium iodide used for?
What are strong iodine solution and saturated solution of potassium iodide used for?
What should patients consult a healthcare provider before taking?
What should patients consult a healthcare provider before taking?
How is methimazole related to propylthiouracil?
How is methimazole related to propylthiouracil?
What is the primary action of propranolol in controlling symptoms of hyperthyroidism?
What is the primary action of propranolol in controlling symptoms of hyperthyroidism?
What should patients be taught about signs and symptoms of?
What should patients be taught about signs and symptoms of?
What is sodium iodide 131I used for?
What is sodium iodide 131I used for?
What should iodine preparations not be followed by?
What should iodine preparations not be followed by?
What should women of childbearing age have before starting methimazole?
What should women of childbearing age have before starting methimazole?
What is the mechanism of action of strong iodine solution and saturated solution of potassium iodide?
What is the mechanism of action of strong iodine solution and saturated solution of potassium iodide?
What is the purpose of using radioactive iodine therapy in the treatment of hyperthyroidism?
What is the purpose of using radioactive iodine therapy in the treatment of hyperthyroidism?
What should patients be instructed to do when taking antithyroid drugs?
What should patients be instructed to do when taking antithyroid drugs?
What is the recommended action for women of childbearing age before starting methimazole?
What is the recommended action for women of childbearing age before starting methimazole?
What is the purpose of using propranolol in patients with symptomatic hyperthyroidism?
What is the purpose of using propranolol in patients with symptomatic hyperthyroidism?
What is the use of strong iodine solution and saturated solution of potassium iodide in the context of hyperthyroidism treatment?
What is the use of strong iodine solution and saturated solution of potassium iodide in the context of hyperthyroidism treatment?
What should patients be cautious about when taking over-the-counter drugs alongside antithyroid medications?
What should patients be cautious about when taking over-the-counter drugs alongside antithyroid medications?
Which radioactive isotope is used to treat hyperthyroidism and thyroid cancer?
Which radioactive isotope is used to treat hyperthyroidism and thyroid cancer?
What is the recommended action for patients experiencing signs of acute liver failure during antithyroid drug treatment?
What is the recommended action for patients experiencing signs of acute liver failure during antithyroid drug treatment?
What is the similarity between methimazole and propylthiouracil?
What is the similarity between methimazole and propylthiouracil?
What is the mechanism by which propranolol controls symptoms of hyperthyroidism?
What is the mechanism by which propranolol controls symptoms of hyperthyroidism?
What should iodine preparations not be followed by?
What should iodine preparations not be followed by?
What is the clinical use of sodium iodide 131I?
What is the clinical use of sodium iodide 131I?
Study Notes
Propylthiouracil: Clinical Use and Nursing Implications
- Propylthiouracil is an FDA-approved thioamide antithyroid drug used to treat hyperthyroidism and related conditions.
- It inhibits thyroid hormone production and peripheral conversion of T4 to T3, with onset of therapeutic effects taking days to weeks.
- The drug is metabolized in the liver and excreted in urine, with a plasma half-life of 1 to 2 hours.
- Propylthiouracil is used in preoperative preparation for thyroidectomy, before or after radioactive iodine therapy, and in the treatment of thyroid storm.
- In hyperthyroidism, drug metabolism may be rapid, requiring higher doses of medications, which may need adjustment as the patient becomes euthyroid.
- It may be used in older adults, but radioactive iodine is often preferred due to fewer adverse effects.
- Propylthiouracil has a BLACK BOX WARNING for severe liver injury, necessitating routine liver function testing.
- Adverse effects may include signs of hypothyroidism, hematologic effects, dermatologic effects, CNS effects, GI effects, and other reported effects.
- The only contraindication to propylthiouracil is a known hypersensitivity reaction to the medication.
- Clinical evidence suggests that propylthiouracil may be associated with vasculitis, requiring close monitoring and aggressive wound care.
- Propylthiouracil may interact with anticoagulants, amiodarone, potassium iodide, sodium iodide, and lithium, requiring careful administration and monitoring.
- Nursing implications include administering the drug in evenly divided doses, assessing for therapeutic effects, and monitoring for adverse effects such as heart failure symptoms and signs of hypothyroidism.
Antithyroid Drug Patient Teaching and Guidelines
- Patients should be taught about signs and symptoms of acute liver failure and to seek immediate medical treatment if they occur
- Periodic tests of thyroid and liver function are necessary during treatment with antithyroid drugs
- Patients should be instructed to take the drug at regular intervals around the clock and to report any adverse effects to the prescriber
- Patients should consult a healthcare provider before taking over-the-counter drugs, as some may contain iodide
- Methimazole is similar to propylthiouracil in action, use, and adverse effects
- Safety alert: women of childbearing age should have a pregnancy test before starting methimazole
- Strong iodine solution and saturated solution of potassium iodide are iodine preparations used in short-term treatment of hyperthyroidism
- Iodine preparations should not be followed by propylthiouracil, methimazole, or radioactive iodine
- Sodium iodide 131I is a radioactive isotope of iodine used to treat hyperthyroidism and thyroid cancer
- Propranolol is recommended in all patients with symptomatic hyperthyroidism, particularly in older adults with cardiovascular conditions
- Propranolol controls symptoms of hyperthyroidism by blocking beta-adrenergic receptors
- Propranolol is useful for controlling symptoms during the delayed response to thioamide drugs and radioactive iodine
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Description
Test your knowledge on propylthiouracil, a thioamide antithyroid drug used in the treatment of hyperthyroidism. Learn about its clinical use, nursing implications, patient teaching, and interactions with other drugs. This quiz covers essential information for healthcare professionals and students in the field.
