أسئلة المحاضرة الـ 15 فسيولوجي (قبل التعديل)
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What occurs during the ascending limb of the spike potential?

  • The membrane remains at resting potential and does not respond to stimuli.
  • Gates of voltage-activated Na+ channels are already closed.
  • The membrane is partially repolarized allowing strong stimuli to reopen Na+ gates. (correct)
  • Membrane is hyperpolarized and cannot initiate another action potential.
  • What best describes the early part of the descending limb of spike potential?

  • The membrane is hyperpolarized, preventing action potential generation.
  • Na+ gates are closed and a sufficient period of repolarization is required. (correct)
  • Membrane potential is at its peak allowing for multiple action potentials.
  • Gates of Na+ channels are fully opened and allow repeated impulses.
  • What limits the number of impulses that a nerve fiber can conduct?

  • The presence of continuous stimuli that trigger depolarization.
  • The speed of neurotransmitter release at the synapse.
  • The overall length of the nerve fiber.
  • The inability of the Na+ channels to open immediately after an action potential. (correct)
  • Which of the following is NOT a cause of failure in nerve impulse propagation?

    <p>Electrical stimulation of the adjacent neuron.</p> Signup and view all the answers

    After a second stimulus is applied during the late part of the descending limb, what is the expected outcome?

    <p>A second action potential can be generated with reduced magnitude.</p> Signup and view all the answers

    During the late phase of the descending limb, how is the membrane state described?

    <p>The membrane is close to the threshold but not quite back to resting state.</p> Signup and view all the answers

    What happens when a strong stimulus is applied during the ascending limb of the spike potential?

    <p>It can reopen some of the Na+ channels that are closed.</p> Signup and view all the answers

    How does severe cooling affect nerve excitability?

    <p>It leads to failure in initiation and propagation of nerve impulses.</p> Signup and view all the answers

    Which type of nerve conducts action potentials at a faster speed?

    <p>Myelinated nerve</p> Signup and view all the answers

    What is the energy consumption difference between continuous and saltatory conduction?

    <p>Saltatory conduction uses less energy</p> Signup and view all the answers

    What initiates the depolarization process in a nerve?

    <p>Stimulation of the nerve</p> Signup and view all the answers

    In saltatory conduction, what does the local current flow cause?

    <p>The polarized resting node to depolarize</p> Signup and view all the answers

    What is the threshold level required for an action potential to occur?

    <p>-55 mV</p> Signup and view all the answers

    What is a key significance of saltatory conduction?

    <p>Increased velocity of conduction</p> Signup and view all the answers

    Which mechanism is involved in continuous conduction?

    <p>Uniform depolarization along the membrane</p> Signup and view all the answers

    What is the resting membrane potential typically in a polarized resting node?

    <p>-70 mV</p> Signup and view all the answers

    What effect does an increase in the internal diameter of a nerve fiber have on conduction velocity?

    <p>Increases conduction velocity</p> Signup and view all the answers

    Which type of nerve fibers are characterized by being thick and myelinated?

    <p>Type A fibers</p> Signup and view all the answers

    What defines orthodromic conduction?

    <p>Conduction in the normal direction</p> Signup and view all the answers

    Which characteristic of myelination most significantly affects conduction velocity?

    <p>Increase in myelin sheath thickness</p> Signup and view all the answers

    What is the conduction speed range for Type B fibers?

    <p>3-15 m/sec</p> Signup and view all the answers

    Which type of nerve fibers are most sensitive to local anesthetics?

    <p>Type C fibers</p> Signup and view all the answers

    What source of energy does a nerve fiber utilize to maintain resting membrane potential (RMP)?

    <p>ATP</p> Signup and view all the answers

    What is the diameter range of Type C fibers?

    <p>0.5-1 μm</p> Signup and view all the answers

    What is one of the main effects of increased metabolic reactions during nerve impulses?

    <p>Increase in CO2 production</p> Signup and view all the answers

    What characterizes the absolute refractory period (ARP) in nerve fibers?

    <p>Excitability is completely lost</p> Signup and view all the answers

    In what phase is the excitability of nerve fibers considered supernormal?

    <p>When excitability is above normal</p> Signup and view all the answers

    What happens during the delayed heat phase of nerve impulse conduction?

    <p>It is caused by ATP reforming after the action potential</p> Signup and view all the answers

    During which phase are stronger stimuli needed to excite a nerve?

    <p>Relative refractory period</p> Signup and view all the answers

    What is the primary reason for the increase in heat production during nerve impulse activity?

    <p>Generation and propagation of nerve impulses</p> Signup and view all the answers

    During which phase does the nerve cell experience partial recovery of excitability?

    <p>Relative refractory period</p> Signup and view all the answers

    What generally follows the temporal rise of excitability in nerve fibers?

    <p>Absolute refractory period</p> Signup and view all the answers

    What is the maximum speed of action potential propagation in myelinated nerves?

    <p>120 m/sec</p> Signup and view all the answers

    How does energy consumption differ between continuous and saltatory conduction?

    <p>Saltatory conduction uses approximately 1% of the energy of continuous conduction</p> Signup and view all the answers

    Which node plays a critical role in saltatory conduction after the depolarization of an adjacent node?

    <p>Node of Ranvier</p> Signup and view all the answers

    What is the lower threshold level required for action potential initiation?

    <p>-55 mV</p> Signup and view all the answers

    Which type of nerve conduction consumes more energy?

    <p>Continuous conduction</p> Signup and view all the answers

    In saltatory conduction, what happens at the nearest node of Ranvier during stimulation?

    <p>The node undergoes depolarization</p> Signup and view all the answers

    What mechanism occurs in continuous conduction at the site of stimulation?

    <p>Local current flows between depolarized and resting areas</p> Signup and view all the answers

    What occurs after a second stimulus is applied during the late part of the descending limb of the action potential?

    <p>Depolarization occurs without producing an action potential</p> Signup and view all the answers

    What is a characteristic of the early part of the descending limb of the action potential?

    <p>Gates of Na+ channels are just closing</p> Signup and view all the answers

    How does local anesthetic, such as lidocaine, affect nerve impulse propagation?

    <p>It prevents initiation and propagation of nerve impulses</p> Signup and view all the answers

    During the ascending limb of the spike potential, what happens to the Na+ channels?

    <p>Most gates are in an open state but can be reopened by new stimuli</p> Signup and view all the answers

    Which of the following accurately reflects the state of the membrane during the late part of the descending limb?

    <p>The membrane is still partially repolarized</p> Signup and view all the answers

    What is a significant result of a second stimulus applied during the ascending limb?

    <p>No further action potential can be initiated</p> Signup and view all the answers

    What defines the mechanism of excitability in relation to nerve impulses?

    <p>Capacity to depolarize and generate action potentials</p> Signup and view all the answers

    What can severely hinder the ability of a nerve to conduct impulses?

    <p>Deep pressure or local anesthetics</p> Signup and view all the answers

    What effect does the thickness of the myelin sheath have on nerve conduction velocity?

    <p>Thicker myelin increases membrane resistance to current</p> Signup and view all the answers

    Which type of nerve fiber exhibits the highest conduction speed?

    <p>Type A fibers</p> Signup and view all the answers

    What is the diameter range for Type B nerve fibers?

    <p>1-3 μm</p> Signup and view all the answers

    What defines antidromic conduction in the context of nerve signaling?

    <p>Conduction occurring in the opposite direction of impulse</p> Signup and view all the answers

    Which factor primarily decreases internal resistance in nerve fibers, thereby increasing conduction velocity?

    <p>Increased internal diameter</p> Signup and view all the answers

    What is a significant characteristic of Type C fibers?

    <p>Thin unmyelinated structure</p> Signup and view all the answers

    What happens to the conduction velocity as the internal diameter of nerve fibers decreases?

    <p>Conduction velocity decreases</p> Signup and view all the answers

    Which of the following factors does NOT affect the conduction speed of action potentials in nerve fibers?

    <p>Purity of the nerve fiber</p> Signup and view all the answers

    What occurs during the absolute refractory period (ARP) of nerve fibers?

    <p>Nerve fibers exhibit complete loss of excitability.</p> Signup and view all the answers

    Which phase indicates that the excitability of nerve fibers is considered to be below normal?

    <p>Subnormal phase of excitability</p> Signup and view all the answers

    During which phase do nerve fibers require stronger than threshold stimuli to be excited?

    <p>Relative refractory period</p> Signup and view all the answers

    Which of the following best describes the increased metabolic reactions during nerve impulse conduction?

    <p>They result in an increased production of CO2 and heat.</p> Signup and view all the answers

    What is the significance of the temporal rise of excitability in nerve fibers?

    <p>It is associated with local depolarization before reaching the firing level.</p> Signup and view all the answers

    What primarily drives the increase in heat production during nerve impulse conduction?

    <p>The generation and propagation of the nerve impulse.</p> Signup and view all the answers

    What characterizes the delayed heat phase of nerve conduction?

    <p>It results from metabolic reactions that reform ATP used during the action potential.</p> Signup and view all the answers

    What is indicated by the numerical values of the stimuli during the relative refractory period (RRP)?

    <p>Stimuli strength can vary from 0 to 100%.</p> Signup and view all the answers

    What is the main difference in speed between continuous and saltatory conduction?

    <p>Saltatory conduction is significantly faster, reaching up to 120 m/sec, while continuous conduction typically ranges from 0.5 to 2 m/sec.</p> Signup and view all the answers

    In what way does saltatory conduction conserve energy compared to continuous conduction?

    <p>Saltatory conduction requires only 1% of the energy that continuous conduction consumes due to fewer depolarization events.</p> Signup and view all the answers

    What causes the initial heat production during the conduction of a nerve impulse?

    <p>The initial heat production is due to the generation and propagation of the nerve impulse.</p> Signup and view all the answers

    Describe the role of the node of Ranvier in saltatory conduction.

    <p>The node of Ranvier serves as the site where action potentials are generated and allows ions to flow in and out, facilitating rapid conduction.</p> Signup and view all the answers

    Explain the difference in excitability during the absolute refractory period compared to the relative refractory period.

    <p>During the absolute refractory period, excitability is completely lost, while in the relative refractory period, excitability is partially recovered.</p> Signup and view all the answers

    What occurs at the site of stimulation during continuous conduction?

    <p>At the site of stimulation, the membrane becomes depolarized to +35 mV, triggering a local current that depolarizes adjacent resting areas.</p> Signup and view all the answers

    How does the excitability of nerve fibers change during the supernormal phase?

    <p>In the supernormal phase, the excitability of the nerve fibers is above normal.</p> Signup and view all the answers

    What threshold must be reached for an action potential to be initiated in both types of conduction?

    <p>The threshold for action potential initiation is typically -55 mV, which must be reached during the depolarization process.</p> Signup and view all the answers

    What metabolic changes occur during nerve impulse transmission?

    <p>There is an increase in CO2 production, glucose utilization, and heat production.</p> Signup and view all the answers

    Explain how potential difference is established during saltatory conduction.

    <p>A potential difference is established between the active node (depolarized to +35 mV) and the adjacent resting node (-70 mV), generating local currents.</p> Signup and view all the answers

    What is the role of ATP reform during the delayed heat phase in nerve impulses?

    <p>ATP reform is necessary to replenish energy used during the action potential.</p> Signup and view all the answers

    What is the effect of myelination on conduction velocity?

    <p>Myelination increases conduction velocity by allowing faster transmission of action potentials through saltatory conduction.</p> Signup and view all the answers

    Describe the consequence of weak stimuli during the subnormal phase of excitability.

    <p>In the subnormal phase, weak stimuli can still excite the nerve but require stronger stimuli than normal.</p> Signup and view all the answers

    What significant advantages does saltatory conduction provide to the nervous system?

    <p>Saltatory conduction enhances conduction velocity and conserves energy, which is crucial for efficient nerve function.</p> Signup and view all the answers

    Discuss the importance of local depolarization in the temporal rise of excitability.

    <p>Local depolarization triggers the initial increase in excitability leading to action potential firing.</p> Signup and view all the answers

    What is the significance of a strong stimulus during the relative refractory period?

    <p>A strong stimulus is required to evoke an action potential during the relative refractory period.</p> Signup and view all the answers

    Describe the effect of strong stimuli on Na+ channels during the ascending limb of the spike potential.

    <p>Strong stimuli can reopen some of the previously activated Na+ channels, but not all of them during the ascending limb.</p> Signup and view all the answers

    What occurs in the nerve membrane during the early part of the descending limb of the action potential?

    <p>The nerve membrane is partially repolarized, and not all Na+ gates are open, leading to a reduced magnitude of the action potential.</p> Signup and view all the answers

    Explain the significance of the negative afterpotential in nerve impulse conduction.

    <p>The negative afterpotential occurs as the membrane hyperpolarizes, making it less likely to fire another action potential immediately.</p> Signup and view all the answers

    What characterizes the absolute refractory period in terms of nerve excitability?

    <p>During the absolute refractory period, the nerve fiber cannot be excited to generate a second action potential, regardless of the strength of a stimulus.</p> Signup and view all the answers

    Identify the relationship between local anesthetic drugs like lidocaine and nerve excitability.

    <p>Local anesthetics such as lidocaine inhibit the initiation and propagation of nerve impulses, reducing excitability.</p> Signup and view all the answers

    How does hyperpolarization of the nerve membrane affect subsequent action potential generation?

    <p>Hyperpolarization increases the threshold for depolarization, requiring a stronger stimulus to generate another action potential.</p> Signup and view all the answers

    Discuss the impact of thermal cooling on nerve impulse behavior.

    <p>Severe cooling leads to a failure in the initiation and propagation of nerve impulses, resulting in decreased nerve excitability.</p> Signup and view all the answers

    What role does sufficient repolarization play in action potential conduction?

    <p>Sufficient repolarization is necessary to reopen Na+ channels, allowing a second action potential to be generated.</p> Signup and view all the answers

    How does the diameter of nerve fibers influence conduction velocity in action potentials?

    <p>A larger diameter decreases internal resistance, which increases conduction velocity.</p> Signup and view all the answers

    What is the role of myelination in the conduction of action potentials?

    <p>Myelination increases membrane resistance, allowing charge to jump between nodes and speeding up conduction.</p> Signup and view all the answers

    Distinguish between orthodromic and antidromic conduction.

    <p>Orthodromic conduction travels in the normal direction, while antidromic conduction occurs in the opposite direction.</p> Signup and view all the answers

    How does the speed of conduction vary among Type A, B, and C fibers?

    <p>Type A fibers conduct at 10-120 m/sec, Type B at 3-15 m/sec, and Type C at 0.5-2 m/sec.</p> Signup and view all the answers

    What types of fibers are most sensitive to local anesthetics and why?

    <p>Type C fibers are most sensitive to local anesthetics due to their thin, unmyelinated structure.</p> Signup and view all the answers

    What is the significance of the resting membrane potential (RMP) in nerve fibers?

    <p>The RMP allows nerve fibers to respond to stimuli and maintain excitability for action potentials.</p> Signup and view all the answers

    Explain the influence of energy consumption in continuous versus saltatory conduction.

    <p>Saltatory conduction consumes less energy than continuous conduction due to fewer action potentials being generated.</p> Signup and view all the answers

    What types of physical stressors influence the sensitivity of nerve fibers, particularly Type A?

    <p>Type A fibers are sensitive to prolonged deep pressure and oxygen lack (hypoxia).</p> Signup and view all the answers

    How does the internal diameter of a nerve fiber influence conduction velocity?

    <p>A larger internal diameter decreases internal resistance, which increases conduction velocity.</p> Signup and view all the answers

    What role does the myelin sheath play in action potential conduction?

    <p>The myelin sheath increases membrane resistance, allowing the charge to jump between nodes, which speeds up conduction.</p> Signup and view all the answers

    Differentiate between orthodromic and antidromic conduction.

    <p>Orthodromic conduction occurs in the normal direction, while antidromic conduction occurs in the opposite direction.</p> Signup and view all the answers

    What is the speed range for Type A nerve fibers?

    <p>Type A fibers conduct action potentials at speeds ranging from 10 to 120 m/sec.</p> Signup and view all the answers

    What types of stimuli are Type C fibers most sensitive to?

    <p>Type C fibers are most sensitive to prolonged deep pressure and oxygen lack (hypoxia).</p> Signup and view all the answers

    Compare the speed of action potential conduction in continuous versus saltatory conduction.

    <p>Continuous conduction is slow, ranging from 0.5 to 2 m/sec, while saltatory conduction can reach speeds of up to 120 m/sec.</p> Signup and view all the answers

    Describe the energy source utilized by nerve fibers to maintain resting membrane potential (RMP).

    <p>Nerve fibers use ATP generated from metabolic processes as the energy source to maintain RMP.</p> Signup and view all the answers

    What role does the node of Ranvier play in saltatory conduction?

    <p>The node of Ranvier facilitates the rapid depolarization of the nerve membrane, allowing the action potential to jump from one node to the next.</p> Signup and view all the answers

    How does the thickness of the myelin sheath relate to conduction velocity?

    <p>Increased myelin sheath thickness enhances conduction velocity by increasing membrane resistance to current.</p> Signup and view all the answers

    Explain the energy consumption difference between continuous and saltatory conduction.

    <p>Continuous conduction consumes more energy, whereas saltatory conduction uses only about 1% of the energy required for continuous conduction.</p> Signup and view all the answers

    What diameter range do Type B nerve fibers typically have?

    <p>Type B nerve fibers generally have a diameter range of 1 to 3 μm.</p> Signup and view all the answers

    Describe the mechanism by which an action potential is generated at a polarized resting node.

    <p>Depolarization occurs when a stimulation causes a local current to flow, transforming the resting potential from -70 mV to the threshold level of -55 mV.</p> Signup and view all the answers

    What is the primary significance of saltatory conduction in nervous system function?

    <p>The primary significance is an increased velocity of conduction and conservation of energy during impulse transmission.</p> Signup and view all the answers

    Identify the resting membrane potential typically found at a polarized resting node.

    <p>The resting membrane potential at a polarized resting node is typically around -70 mV.</p> Signup and view all the answers

    How does the metabolic energy requirement of continuous conduction compare to that of saltatory conduction?

    <p>Continuous conduction requires a higher metabolic energy output compared to saltatory conduction, which is more energy-efficient.</p> Signup and view all the answers

    What happens to the neuronal membrane potential after it reaches +35 mV during action potential propagation?

    <p>After reaching +35 mV, the neuronal membrane repolarizes, transitioning back toward the resting membrane potential.</p> Signup and view all the answers

    What occurs in the membrane state during the early part of the descending limb after an action potential?

    <p>The membrane is partially repolarized and not all Na+ channels are opened.</p> Signup and view all the answers

    How does a second stimulus affect the membrane during the late part of the descending limb?

    <p>It can lead to depolarization and the production of a second action potential if the membrane is sufficiently repolarized.</p> Signup and view all the answers

    What physiological mechanisms underlie the excitability of nerve fibers?

    <p>Excitability relates to the opening and closing of voltage-gated Na+ channels following depolarization and repolarization phases.</p> Signup and view all the answers

    What happens during the hyperpolarization phase of a nerve fiber's action potential?

    <p>The membrane potential moves away from the threshold, making it less likely for a new action potential to occur.</p> Signup and view all the answers

    Describe the impact of mechanical stimuli, such as deep pressure, on nerve excitability.

    <p>Mechanical stimuli can alter the excitability of nerve fibers by affecting the permeability of the membrane to ions.</p> Signup and view all the answers

    What is the role of cooling in nerve impulse conduction?

    <p>Severe cooling can impede nerve excitability and conductivity, potentially leading to failure in impulse propagation.</p> Signup and view all the answers

    What characterizes the condition of a nerve fiber during the absolute refractory period?

    <p>During this period, the nerve fiber cannot be activated to generate another action potential, regardless of the stimulus strength.</p> Signup and view all the answers

    How does the repolarization process affect the conduction capabilities of nerve fibers?

    <p>Repolarization resets the membrane potential, establishing conditions for future action potentials but temporarily limits the number of impulses that can be conducted.</p> Signup and view all the answers

    What are the two phases of heat production associated with nerve impulse conduction?

    <p>The two phases are initial heat, which occurs during the generation and propagation of the nerve impulse, and delayed heat, which results from metabolic reactions to reform ATP.</p> Signup and view all the answers

    Explain the absolute refractory period (ARP) in terms of nerve excitability.

    <p>During the ARP, the excitability of the nerve fiber is completely lost, meaning no stimuli can excite the nerve regardless of strength.</p> Signup and view all the answers

    What governs the excitability of nerve fibers during the relative refractory period (RRP)?

    <p>During the RRP, the nerve fiber's excitability is partially recovered, requiring stronger stimuli than usual to evoke an action potential.</p> Signup and view all the answers

    Describe the significance of the supernormal phase of excitability.

    <p>In the supernormal phase, the excitability of the nerve fiber is above normal, allowing weaker stimuli to excite the nerve.</p> Signup and view all the answers

    What effect does increased metabolic activity have on CO2 production during nerve impulses?

    <p>Increased metabolic activity leads to heightened CO2 production as a byproduct of enhanced metabolic reactions during nerve impulse conduction.</p> Signup and view all the answers

    Identify how glucose utilization is affected during nerve impulse conduction.

    <p>There is an increase in glucose utilization when nerve impulses are conducted, reflecting the heightened energy demands of the active nerve fibers.</p> Signup and view all the answers

    What role does local response play during the temporal rise of excitability?

    <p>The local response is associated with local depolarization in the nerve fiber, which leads to a temporary increase in excitability before reaching the firing level.</p> Signup and view all the answers

    How does the delayed heat phase relate to ATP reform during nerve impulse activity?

    <p>The delayed heat phase is attributed to the metabolic reactions needed to reform ATP that was consumed during the action potential.</p> Signup and view all the answers

    Study Notes

    Propagation of Action Potentials

    • Action potentials can be propagated continuously or saltatorily

    • Continuous propagation: Unmyelinated axons. Slow (0.5-2 m/sec). More energy consumption. Stimulation depolarizes the membrane at the site, then the depolarized area stimulates the adjacent area, generating local current flows. This creates a domino effect, causing the polarized area to reach the threshold level (-55 mV) and generate an action potential sequentially along the axon.

    • Saltatory propagation: Myelinated axons. Fast (up to 120 m/sec). Lower energy consumption (1% of continuous). Stimulation depolarizes the membrane at the nodes of Ranvier. The depolarized node creates a local current that jumps to the next node, skipping the myelin-coated segments. This rapid jumping of the action potential allows for faster conduction.

    Factors Affecting Conduction Speed

    • Internal diameter of nerve fibers: Larger diameter fibers have lower internal resistance, leading to faster conduction.
    • Degree of myelination: Greater myelination increases membrane resistance, speeding up action potential propagation.

    Types of Nerve Fibers

    • Type A fibers: Thick myelinated. Somatic motor and sensory nerves. High speed (10-120 m/sec). Sensitive to pressure, alpha, beta, delta, and gamma.
    • Type B fibers: Thin myelinated. Autonomic preganglionic nerves. Moderate speed (3-15 m/sec). Sensitive to O2 lack and hypoxia.
    • Type C fibers: Thin unmyelinated. Somatic sensory (slow pain) and autonomic postganglionic. Slowest speed (0.5-1 m/sec). Sensitive to local anesthetics

    Changes in Nerve During Conduction

    • Electrical changes: Spike potentials and after-potentials.
    • Metabolic changes: Increased energy use (ATP), increased CO2 production, and glucose utilization. Increase in heat production during nerve impulse.
    • Thermal changes: Heat production during impulse generation and propagation, initial and delayed heat phases.

    Excitability Changes

    • Temporal rise in excitability: Associated with local responses in nerve fibers, before reaching firing level.
    • Absolute refractory period (ARP): Complete loss of excitability in nerve fibers.
    • Relative refractory period (RRP): Partial recovery of excitability, but still below normal.
    • Supernormal phase: Excitability is above normal.
    • Subnormal phase: Excitability below normal

    Nerve Block

    • Definition: Failure of initiation and propagation of nerve impulses.
    • Causes:
      • Thermal: Severe cooling
      • Mechanical: Deep pressure
      • Chemical: Local anesthetics (e.g., lidocaine), membrane stabilizers (changes in Ca, Na, K concentrations).

    Multiple Sclerosis (MS)

    • Definition: Autoimmune disease attacking myelin.
    • Cause: Inflammation and injury to myelin sheath, surrounding nerve fibers.
    • Incidence: Women more than men, usually diagnosed 20-50 years old
    • Clinical picture: Muscle weakness, fatigue, sensory issues, blurred vision, slurred speech, bladder dysfunction.
    • Treatment: Steroids (suppress immune system), Decrease antibodies formation.

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