Prognosis in CML Without Philadelphia Chromosome

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Questions and Answers

Which of the following is a characteristic of qualitative disorders of platelets?

  • Decreased platelet count
  • Increased platelet count
  • Abnormal platelet function (correct)
  • All of the above

In Bernard Soulier Syndrome (BSS), which platelet surface protein complex is missing or dysfunctional?

  • GPIb/IX/V (correct)
  • Collagen receptor
  • GPIIb/IIIa
  • Fibrinogen receptor

What is the primary consequence of the absence or dysfunction of the GPIb/IX/V complex in Bernard Soulier Syndrome?

  • Impaired platelet secretion
  • Decreased platelet aggregation
  • Defective platelet adhesion (correct)
  • Increased platelet adhesion

Which of the following is a characteristic of thrombocytopenia?

<p>Decreased platelet count (B)</p> Signup and view all the answers

Which of the following conditions is associated with an increase in platelet count?

<p>Thrombocytosis (C)</p> Signup and view all the answers

Which of the following is a myeloproliferative or lymphoproliferative disorder that can lead to an increased platelet count?

<p>All of the above (D)</p> Signup and view all the answers

What does the suffix 'itis' attached after an organ mean according to Robins from general pathology?

<p>Inflammation (B)</p> Signup and view all the answers

Which therapeutic drug is mentioned in the text?

<p>Vincristine (B)</p> Signup and view all the answers

What condition makes a person unable to become pregnant while taking Vitamin A?

<p>All-Trans-Retenoic Acid consumption (C)</p> Signup and view all the answers

Which of the following are examples of cytokines as mentioned in the text?

<p>Interleukins, Tumor Necrosis Factor, Erythropoietin (C)</p> Signup and view all the answers

Which clinical findings can help distinguish between clonal and secondary/reactive thrombocytosis?

<p>Essential Thrombocythemia and Myeloproliferative Disorders (B)</p> Signup and view all the answers

Which of the following are among the myeloproliferative disorders mentioned in the text?

<p>Polycythemia Vera, CML, Myelofibrosis (C)</p> Signup and view all the answers

What is the characteristic of platelets in Quebec Platelet Syndrome?

<p>Normal to reduced platelet count with proteolytic degradation of -granule proteins (D)</p> Signup and view all the answers

Which component of the thromboxane pathway is not mentioned in the text?

<p>Lipoxygenase (B)</p> Signup and view all the answers

What is the term used to describe hereditary absence or abnormalities of the components of the thromboxane pathway?

<p>Aspirin-like defects (C)</p> Signup and view all the answers

What is the inheritance pattern of Quebec Platelet Syndrome?

<p>Autosomal dominant (C)</p> Signup and view all the answers

Which of the following is a component of the dense granules in platelets?

<p>Serotonin (C)</p> Signup and view all the answers

Which of the following is a characteristic of Bernard Soulier Syndrome (BSS)?

<p>Absence or abnormality of the glycoprotein Ib-IX-V complex (C)</p> Signup and view all the answers

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