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Prognosis in CML Without Philadelphia Chromosome

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Prognosis in CML Without Philadelphia Chromosome

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Questions and Answers

Which of the following is a characteristic of qualitative disorders of platelets?

Decreased platelet count

Increased platelet count

Abnormal platelet function (correct)

All of the above

In Bernard Soulier Syndrome (BSS), which platelet surface protein complex is missing or dysfunctional?

GPIb/IX/V (correct)

Collagen receptor

GPIIb/IIIa

Fibrinogen receptor

What is the primary consequence of the absence or dysfunction of the GPIb/IX/V complex in Bernard Soulier Syndrome?

Impaired platelet secretion

Decreased platelet aggregation

Defective platelet adhesion (correct)

Increased platelet adhesion

Which of the following is a characteristic of thrombocytopenia?

Decreased platelet count Signup and view all the answers

Which of the following conditions is associated with an increase in platelet count?

Thrombocytosis Signup and view all the answers

Which of the following is a myeloproliferative or lymphoproliferative disorder that can lead to an increased platelet count?

All of the above Signup and view all the answers

What does the suffix 'itis' attached after an organ mean according to Robins from general pathology?

Inflammation Signup and view all the answers

Which therapeutic drug is mentioned in the text?

Vincristine Signup and view all the answers

What condition makes a person unable to become pregnant while taking Vitamin A?

All-Trans-Retenoic Acid consumption Signup and view all the answers

Which of the following are examples of cytokines as mentioned in the text?

Interleukins, Tumor Necrosis Factor, Erythropoietin Signup and view all the answers

Which clinical findings can help distinguish between clonal and secondary/reactive thrombocytosis?

Essential Thrombocythemia and Myeloproliferative Disorders Signup and view all the answers

Which of the following are among the myeloproliferative disorders mentioned in the text?

Polycythemia Vera, CML, Myelofibrosis Signup and view all the answers

What is the characteristic of platelets in Quebec Platelet Syndrome?

Normal to reduced platelet count with proteolytic degradation of -granule proteins Signup and view all the answers

Which component of the thromboxane pathway is not mentioned in the text?

Lipoxygenase Signup and view all the answers

What is the term used to describe hereditary absence or abnormalities of the components of the thromboxane pathway?

Aspirin-like defects Signup and view all the answers

What is the inheritance pattern of Quebec Platelet Syndrome?

Autosomal dominant Signup and view all the answers

Which of the following is a component of the dense granules in platelets?

Serotonin Signup and view all the answers

Which of the following is a characteristic of Bernard Soulier Syndrome (BSS)?

Absence or abnormality of the glycoprotein Ib-IX-V complex Signup and view all the answers