Prognosis in CML Without Philadelphia Chromosome
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Questions and Answers

Which of the following is a characteristic of qualitative disorders of platelets?

  • Decreased platelet count
  • Increased platelet count
  • Abnormal platelet function (correct)
  • All of the above
  • In Bernard Soulier Syndrome (BSS), which platelet surface protein complex is missing or dysfunctional?

  • GPIb/IX/V (correct)
  • Collagen receptor
  • GPIIb/IIIa
  • Fibrinogen receptor
  • What is the primary consequence of the absence or dysfunction of the GPIb/IX/V complex in Bernard Soulier Syndrome?

  • Impaired platelet secretion
  • Decreased platelet aggregation
  • Defective platelet adhesion (correct)
  • Increased platelet adhesion
  • Which of the following is a characteristic of thrombocytopenia?

    <p>Decreased platelet count</p> Signup and view all the answers

    Which of the following conditions is associated with an increase in platelet count?

    <p>Thrombocytosis</p> Signup and view all the answers

    Which of the following is a myeloproliferative or lymphoproliferative disorder that can lead to an increased platelet count?

    <p>All of the above</p> Signup and view all the answers

    What does the suffix 'itis' attached after an organ mean according to Robins from general pathology?

    <p>Inflammation</p> Signup and view all the answers

    Which therapeutic drug is mentioned in the text?

    <p>Vincristine</p> Signup and view all the answers

    What condition makes a person unable to become pregnant while taking Vitamin A?

    <p>All-Trans-Retenoic Acid consumption</p> Signup and view all the answers

    Which of the following are examples of cytokines as mentioned in the text?

    <p>Interleukins, Tumor Necrosis Factor, Erythropoietin</p> Signup and view all the answers

    Which clinical findings can help distinguish between clonal and secondary/reactive thrombocytosis?

    <p>Essential Thrombocythemia and Myeloproliferative Disorders</p> Signup and view all the answers

    Which of the following are among the myeloproliferative disorders mentioned in the text?

    <p>Polycythemia Vera, CML, Myelofibrosis</p> Signup and view all the answers

    What is the characteristic of platelets in Quebec Platelet Syndrome?

    <p>Normal to reduced platelet count with proteolytic degradation of -granule proteins</p> Signup and view all the answers

    Which component of the thromboxane pathway is not mentioned in the text?

    <p>Lipoxygenase</p> Signup and view all the answers

    What is the term used to describe hereditary absence or abnormalities of the components of the thromboxane pathway?

    <p>Aspirin-like defects</p> Signup and view all the answers

    What is the inheritance pattern of Quebec Platelet Syndrome?

    <p>Autosomal dominant</p> Signup and view all the answers

    Which of the following is a component of the dense granules in platelets?

    <p>Serotonin</p> Signup and view all the answers

    Which of the following is a characteristic of Bernard Soulier Syndrome (BSS)?

    <p>Absence or abnormality of the glycoprotein Ib-IX-V complex</p> Signup and view all the answers

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