Chronic Myeloid Leukemia (CML) Overview

Fatigue = Early symptom of CML Night sweats = Early symptom of CML Abdominal pain = Later symptom of CML due to splenomegaly Bone pain = Later symptom of CML

Philadelphia chromosome translocation = Demonstration of Ph-chromosome Bone marrow biopsy = Shows small megakaryocytes with hypolobulated nuclei Lab tests = Demonstration of the Ph-chromosome is the No.1 specific test Biopsy = Shows dwarf megakaryocytes

Imatinib = BCR-ABL tyrosine kinase inhibitor (TKI) BM-transplantation = Attempted early for a cure Alpha-interferon = Helps eliminate the Ph-chromosome TKI = Given in the chronic phase of CML

<p>Etiology = Unknown Philadelphia chromosome translocation = Leads to tyrosine kinase enzyme activity Chronic myeloproliferative neoplasm = Characterized by the massive overproduction of myeloid cells CML = A type of leukemia</p> Signup and view all the answers

<p>Leukemoid reactions = A differential diagnosis of CML CML = A type of chronic myeloproliferative neoplasm BM-transplantation = A treatment option for CML Alpha-interferon = A treatment option for CML</p> Signup and view all the answers