Prodrug Chemistry Quiz

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Pharmacologically inactive chemical derivatives used to alter drug properties (correct)
Biologically active compounds used to enhance drug effects
Active chemicals used to increase drug usefulness
Inactive substances used to decrease drug toxicity

<p>Latentiated drugs, bioreversible derivatives, congeners (C)</p> Signup and view all the answers

<p>Conversion to the original drug followed by rapid elimination of the released group (D)</p> Signup and view all the answers

Pharmacologically inactive chemical derivatives used to alter drug properties.

Enzyme + Drug + Cap = Prodrug

Enzymatic or chemical transformation to activate the drug.

Latentiated drugs, bioreversible derivatives, congeners.

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Conversion to the original drug followed by rapid elimination of the released group.

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Albert and his co-workers described prodrugs as inactive or partially active compounds that undergo biotransformation to an active drug.
In the laboratory, during the synthesis of a prodrug, the active drug is modified to create a new compound which is inactive or partially active.
In the body, the prodrug is converted back to the active drug through metabolic processes.
Prodrugs are also known as drug latentiation.
The ideal outcome for a prodrug at the site of action is that it releases the active drug, which then exerts its therapeutic effect.