Prodrug Chemistry Quiz

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Questions and Answers

What did Albert and his co-workers describe prodrugs as?

  • Pharmacologically inactive chemical derivatives used to alter drug properties (correct)
  • Biologically active compounds used to enhance drug effects
  • Active chemicals used to increase drug usefulness
  • Inactive substances used to decrease drug toxicity

What occurs in the laboratory during the synthesis of a prodrug?

  • Cap + Drug = Enzyme + Prodrug
  • Enzyme + Drug + Cap = Prodrug (correct)
  • Drug + Cap = Prodrug + Enzyme
  • Enzyme + Prodrug + Cap = Drug

What happens to the prodrug in the body?

  • Immediate release of the original drug
  • Rapid elimination of the derivatizing group
  • Enzymatic or chemical transformation (correct)
  • Biological barrier formation

What are prodrugs also known as?

<p>Latentiated drugs, bioreversible derivatives, congeners (C)</p> Signup and view all the answers

What is the ideal outcome for a prodrug at the site of action?

<p>Conversion to the original drug followed by rapid elimination of the released group (D)</p> Signup and view all the answers

Flashcards

Prodrug Definition

Pharmacologically inactive chemical derivatives used to alter drug properties.

Prodrug Synthesis

Enzyme + Drug + Cap = Prodrug

Prodrug's Body Process

Enzymatic or chemical transformation to activate the drug.

Alternate Names for Prodrugs

Latentiated drugs, bioreversible derivatives, congeners.

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Ideal Prodrug Outcome

Conversion to the original drug followed by rapid elimination of the released group.

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Study Notes

Prodrugs

  • Albert and his co-workers described prodrugs as inactive or partially active compounds that undergo biotransformation to an active drug.
  • In the laboratory, during the synthesis of a prodrug, the active drug is modified to create a new compound which is inactive or partially active.
  • In the body, the prodrug is converted back to the active drug through metabolic processes.
  • Prodrugs are also known as drug latentiation.
  • The ideal outcome for a prodrug at the site of action is that it releases the active drug, which then exerts its therapeutic effect.

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