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Questions and Answers
What type of activation reaction is mostly utilized by bioprecursor prodrugs?
What type of activation reaction is mostly utilized by bioprecursor prodrugs?
- Reductive
- Oxidative (correct)
- Protonation
- Hydrolysis
What is the activation mechanism of PPIs, with omeprazole as an example?
What is the activation mechanism of PPIs, with omeprazole as an example?
- Protonation (correct)
- Reduction
- Oxidation
- Hydrolysis
What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?
What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?
- Hydrogen bond
- Covalent bond (correct)
- Ionic bond
- Van der Waals bond
Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?
Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?
What type of reaction does unsubstituted isoxazoles undergo for activation?
What type of reaction does unsubstituted isoxazoles undergo for activation?
What is the type of activation reaction mostly utilized by bioprecursor prodrugs?
What is the type of activation reaction mostly utilized by bioprecursor prodrugs?
Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?
Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?
What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?
What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?
What type of reaction does unsubstituted isoxazoles undergo for activation?
What type of reaction does unsubstituted isoxazoles undergo for activation?
What is the mechanism of activation of PPIs, with omeprazole as an example?
What is the mechanism of activation of PPIs, with omeprazole as an example?
What is the primary mechanism of activation for carrier-linked prodrugs?
What is the primary mechanism of activation for carrier-linked prodrugs?
Which group of drugs mostly utilize oxidative or reductive activation reactions for activation?
Which group of drugs mostly utilize oxidative or reductive activation reactions for activation?
What type of activation reaction is involved in the transformation of omeprazole to its active form inside the canaliculus of the cell?
What type of activation reaction is involved in the transformation of omeprazole to its active form inside the canaliculus of the cell?
Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?
Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?
What type of activation reaction is known to occur in unsubstituted isoxazoles like leflunomide?
What type of activation reaction is known to occur in unsubstituted isoxazoles like leflunomide?
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