Bioprecursor Prodrugs: Activation Mechanisms and Examples
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Questions and Answers

What type of activation reaction is mostly utilized by bioprecursor prodrugs?

  • Reductive
  • Oxidative (correct)
  • Protonation
  • Hydrolysis

What is the activation mechanism of PPIs, with omeprazole as an example?

  • Protonation (correct)
  • Reduction
  • Oxidation
  • Hydrolysis

What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?

  • Hydrogen bond
  • Covalent bond (correct)
  • Ionic bond
  • Van der Waals bond

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

<p>Pyridine ring (D)</p> Signup and view all the answers

What type of reaction does unsubstituted isoxazoles undergo for activation?

<p>Elimination (A)</p> Signup and view all the answers

What is the type of activation reaction mostly utilized by bioprecursor prodrugs?

<p>Oxidative activation (C)</p> Signup and view all the answers

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

<p>Pyridine ring (A)</p> Signup and view all the answers

What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?

<p>Covalent bond (B)</p> Signup and view all the answers

What type of reaction does unsubstituted isoxazoles undergo for activation?

<p>Elimination reaction (D)</p> Signup and view all the answers

What is the mechanism of activation of PPIs, with omeprazole as an example?

<p>Protonation or Proton Activation (B)</p> Signup and view all the answers

What is the primary mechanism of activation for carrier-linked prodrugs?

<p>Hydrolysis reactions (A)</p> Signup and view all the answers

Which group of drugs mostly utilize oxidative or reductive activation reactions for activation?

<p>Bioprecursor prodrugs (B)</p> Signup and view all the answers

What type of activation reaction is involved in the transformation of omeprazole to its active form inside the canaliculus of the cell?

<p>Protonation reaction (A)</p> Signup and view all the answers

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

<p>Pyridine ring (D)</p> Signup and view all the answers

What type of activation reaction is known to occur in unsubstituted isoxazoles like leflunomide?

<p>Elimination reaction (D)</p> Signup and view all the answers

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