Bioprecursor Prodrugs: Activation Mechanisms and Examples

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What type of activation reaction is mostly utilized by bioprecursor prodrugs?

Reductive

Oxidative (correct)

Protonation

Hydrolysis

What is the activation mechanism of PPIs, with omeprazole as an example?

Protonation (correct)

Reduction

Oxidation

Hydrolysis

What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?

Hydrogen bond

Covalent bond (correct)

Ionic bond

Van der Waals bond

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

Pyridine ring Signup and view all the answers

What type of reaction does unsubstituted isoxazoles undergo for activation?

Elimination Signup and view all the answers

What is the type of activation reaction mostly utilized by bioprecursor prodrugs?

Oxidative activation Signup and view all the answers

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

Pyridine ring Signup and view all the answers

What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?

Covalent bond Signup and view all the answers

What type of reaction does unsubstituted isoxazoles undergo for activation?

Elimination reaction Signup and view all the answers

What is the mechanism of activation of PPIs, with omeprazole as an example?

Protonation or Proton Activation Signup and view all the answers

What is the primary mechanism of activation for carrier-linked prodrugs?

Hydrolysis reactions Signup and view all the answers

Which group of drugs mostly utilize oxidative or reductive activation reactions for activation?

Bioprecursor prodrugs Signup and view all the answers

What type of activation reaction is involved in the transformation of omeprazole to its active form inside the canaliculus of the cell?

Protonation reaction Signup and view all the answers

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

Pyridine ring Signup and view all the answers

What type of activation reaction is known to occur in unsubstituted isoxazoles like leflunomide?

Elimination reaction Signup and view all the answers

Bioprecursor Prodrugs: Activation Mechanisms and Examples

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Questions and Answers

What type of activation reaction is mostly utilized by bioprecursor prodrugs?

What is the activation mechanism of PPIs, with omeprazole as an example?

What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

What type of reaction does unsubstituted isoxazoles undergo for activation?

What is the type of activation reaction mostly utilized by bioprecursor prodrugs?

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

What type of bond forms between omeprazole and the cysteine residue of H,K+-ATPase?

What type of reaction does unsubstituted isoxazoles undergo for activation?

What is the mechanism of activation of PPIs, with omeprazole as an example?

What is the primary mechanism of activation for carrier-linked prodrugs?

Which group of drugs mostly utilize oxidative or reductive activation reactions for activation?

What type of activation reaction is involved in the transformation of omeprazole to its active form inside the canaliculus of the cell?

Which functional group of omeprazole becomes protonated inside the canaliculus of the cell?

What type of activation reaction is known to occur in unsubstituted isoxazoles like leflunomide?

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Bioprecursor Prodrugs Lecture: Activation Types

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