Probing PPIs
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Questions and Answers

Which drug is commonly used for symptomatic relief of dyspepsia but is rarely used as the primary therapeutic agent for peptic ulcers?

  • Histamine inhibitors
  • Antacids (correct)
  • NSAIDs
  • H. pylori eradication drugs
  • Which combination of antacids is commonly used to avoid constipation and phosphate depletion?

  • Aluminum hydroxide and magnesium hydroxide (correct)
  • Aluminum hydroxide and calcium carbonate
  • Calcium carbonate and sodium bicarbonate
  • Magnesium hydroxide and sodium bicarbonate
  • Which antacid should not be used in patients with chronic renal failure due to the risk of hypermagnesemia?

  • Sodium bicarbonate
  • Aluminum hydroxide
  • Calcium carbonate
  • Magnesium hydroxide (correct)
  • What potential problem can arise from long-term use of calcium carbonate as an antacid?

    <p>Milk-alkali syndrome</p> Signup and view all the answers

    Which drug may induce systemic alkalosis when used as an antacid?

    <p>Sodium bicarbonate</p> Signup and view all the answers

    Which of the following is a potential side effect of long-term use of PPIs?

    <p>Osteoporosis</p> Signup and view all the answers

    Which of the following is a potential drug interaction involving PPIs?

    <p>Aspirin and PPIs</p> Signup and view all the answers

    Which of the following is a recommendation for patients taking clopidogrel with aspirin and other GI risk factors for bleeding?

    <p>Take PPIs 30 min before breakfast</p> Signup and view all the answers

    Which of the following is a potential side effect of long-term PPI use?

    <p>Dementia</p> Signup and view all the answers

    Which of the following is a potential risk factor for long-term side effects of PPIs?

    <p>Concomitant chronic diseases</p> Signup and view all the answers

    Which H2 receptor antagonist is associated with weak antiandrogenic side effects such as reversible gynecomastia and impotence?

    <p>Cimetidine</p> Signup and view all the answers

    Which H2 receptor antagonist does not bind to hepatic cytochrome P450?

    <p>Nizatidine</p> Signup and view all the answers

    Which H2 receptor antagonist was taken off the market due to contamination with a known carcinogen?

    <p>Ranitidine</p> Signup and view all the answers

    Which proton pump inhibitor has a dual delayed-release system aimed at improving treatment of gastroesophageal reflux disease (GERD)?

    <p>Lansoprazole</p> Signup and view all the answers

    Which proton pump inhibitor is available in an orally disintegrating tablet that can be taken with or without water?

    <p>Lansoprazole</p> Signup and view all the answers

    Which of the following is NOT a potential side effect of long-term PPI use?

    <p>Spontaneous bacterial peritonitis</p> Signup and view all the answers

    What is the mechanism for PPI-induced collagenous colitis?

    <p>Inhibition of collagen gene expression</p> Signup and view all the answers

    Which of the following drugs may interact significantly with PPIs?

    <p>Omeprazole</p> Signup and view all the answers

    What is the main reason why PPIs are maximized if administered before a meal?

    <p>To activate the pumps</p> Signup and view all the answers

    How long does it take for gastric acid secretion to return to normal levels after discontinuation of PPIs?

    <p>2-5 days</p> Signup and view all the answers

    Which class of agents inhibits gastric acid secretion via potassium competitive binding of the H+,K+-ATPase?

    <p>P-CAPs</p> Signup and view all the answers

    Which agent has been awarded Fast Track status by the FDA for the treatment of H. pylori in combination with both amoxicillin and clarithromycin and with amoxicillin alone?

    <p>Vonoprazan</p> Signup and view all the answers

    Which compound becomes a viscous paste within the stomach and duodenum, binding primarily to sites of active ulceration?

    <p>Sucralfate</p> Signup and view all the answers

    Which bismuth-containing compound is commonly used as one of the agents in an anti-H. pylori regimen?

    <p>Bismuth subsalicylate (BSS)</p> Signup and view all the answers

    What is the main toxicity associated with prostaglandin analogues used for the treatment of PUD?

    <p>Diarrhea</p> Signup and view all the answers

    Which of the following is NOT a concern raised about the widespread use of antibiotics for H. pylori therapy?

    <p>Decreased efficacy</p> Signup and view all the answers

    Which of the following is the most effective treatment duration for H. pylori therapy?

    <p>14 days</p> Signup and view all the answers

    Which of the following is NOT one of the agents frequently used in H. pylori therapy?

    <p>Ciprofloxacin</p> Signup and view all the answers

    What factors should be considered when choosing a particular H. pylori therapy regimen?

    <p>Efficacy, patient tolerance, existing antibiotic resistance, prior antibiotic use, and cost of the drugs</p> Signup and view all the answers

    Why is dual therapy not recommended for H. pylori eradication?

    <p>Low efficacy rates</p> Signup and view all the answers

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