30 Questions
Which drug is commonly used for symptomatic relief of dyspepsia but is rarely used as the primary therapeutic agent for peptic ulcers?
Antacids
Which combination of antacids is commonly used to avoid constipation and phosphate depletion?
Aluminum hydroxide and magnesium hydroxide
Which antacid should not be used in patients with chronic renal failure due to the risk of hypermagnesemia?
Magnesium hydroxide
What potential problem can arise from long-term use of calcium carbonate as an antacid?
Milk-alkali syndrome
Which drug may induce systemic alkalosis when used as an antacid?
Sodium bicarbonate
Which of the following is a potential side effect of long-term use of PPIs?
Osteoporosis
Which of the following is a potential drug interaction involving PPIs?
Aspirin and PPIs
Which of the following is a recommendation for patients taking clopidogrel with aspirin and other GI risk factors for bleeding?
Take PPIs 30 min before breakfast
Which of the following is a potential side effect of long-term PPI use?
Dementia
Which of the following is a potential risk factor for long-term side effects of PPIs?
Concomitant chronic diseases
Which H2 receptor antagonist is associated with weak antiandrogenic side effects such as reversible gynecomastia and impotence?
Cimetidine
Which H2 receptor antagonist does not bind to hepatic cytochrome P450?
Nizatidine
Which H2 receptor antagonist was taken off the market due to contamination with a known carcinogen?
Ranitidine
Which proton pump inhibitor has a dual delayed-release system aimed at improving treatment of gastroesophageal reflux disease (GERD)?
Lansoprazole
Which proton pump inhibitor is available in an orally disintegrating tablet that can be taken with or without water?
Lansoprazole
Which of the following is NOT a potential side effect of long-term PPI use?
Spontaneous bacterial peritonitis
What is the mechanism for PPI-induced collagenous colitis?
Inhibition of collagen gene expression
Which of the following drugs may interact significantly with PPIs?
Omeprazole
What is the main reason why PPIs are maximized if administered before a meal?
To activate the pumps
How long does it take for gastric acid secretion to return to normal levels after discontinuation of PPIs?
2-5 days
Which class of agents inhibits gastric acid secretion via potassium competitive binding of the H+,K+-ATPase?
P-CAPs
Which agent has been awarded Fast Track status by the FDA for the treatment of H. pylori in combination with both amoxicillin and clarithromycin and with amoxicillin alone?
Vonoprazan
Which compound becomes a viscous paste within the stomach and duodenum, binding primarily to sites of active ulceration?
Sucralfate
Which bismuth-containing compound is commonly used as one of the agents in an anti-H. pylori regimen?
Bismuth subsalicylate (BSS)
What is the main toxicity associated with prostaglandin analogues used for the treatment of PUD?
Diarrhea
Which of the following is NOT a concern raised about the widespread use of antibiotics for H. pylori therapy?
Decreased efficacy
Which of the following is the most effective treatment duration for H. pylori therapy?
14 days
Which of the following is NOT one of the agents frequently used in H. pylori therapy?
Ciprofloxacin
What factors should be considered when choosing a particular H. pylori therapy regimen?
Efficacy, patient tolerance, existing antibiotic resistance, prior antibiotic use, and cost of the drugs
Why is dual therapy not recommended for H. pylori eradication?
Low efficacy rates
Quiz: Understanding the Impact of Long-Term PPI Use on Nutritional Deficiencies Test your knowledge on the potential consequences of long-term proton pump inhibitor (PPI) use. Learn about the association between PPIs and deficiencies in iron, vitamin B12, and magnesium. Discover the latest research findings and explore the importance of confirming observations before making recommendations.
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