Probing PPIs

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Which of the following is the mainstay of treatment for peptic ulcer disease?

Eradication of H. pylori (correct)

Antacids

NSAIDs

Histamine inhibitors

What is the primary therapeutic agent for peptic ulcers?

Eradication of H. pylori (correct)

Histamine inhibitors

NSAIDs

Antacids

Which of the following antacids should not be used in chronic renal failure patients?

Sodium bicarbonate

Calcium carbonate

Magnesium hydroxide (correct)

Aluminum hydroxide

Which of the following H2 receptor antagonists is known to have weak antiandrogenic side effects?

Cimetidine Signup and view all the answers

Which of the following H2 receptor antagonists was taken off the market due to contamination with a known carcinogen?

Ranitidine Signup and view all the answers

Which of the following proton pump inhibitors is available as a parenteral formulation for intravenous use?

Pantoprazole Signup and view all the answers

Which of the following proton pump inhibitors is the S-enantiomer of omeprazole?

Esomeprazole Signup and view all the answers

Which of the following is NOT a concern raised about the widespread use of antibiotics for H. pylori therapy?

Decreased efficacy Signup and view all the answers

What is the recommended duration for combination therapy for H. pylori?

14 days Signup and view all the answers

Which of the following is NOT mentioned as one of the agents used frequently in H. pylori therapy?

Ciprofloxacin Signup and view all the answers

Which class of agents inhibits gastric acid secretion via potassium competitive binding of the H+,K+-ATPase?

P-CAPs Signup and view all the answers

Which agent has been awarded Fast Track status by the FDA for the treatment of H. pylori in combination with antibiotics?

Vonoprazan Signup and view all the answers

What is the most common toxicity noted with prostaglandin analogues?

Diarrhea Signup and view all the answers

Which drug should be avoided in patients with chronic renal insufficiency to prevent aluminum-induced neurotoxicity?

Sucralfate Signup and view all the answers

Which of the following is NOT a potential side effect of long-term use of PPIs?

Gastric acid hypersecretion Signup and view all the answers

What is the recommended administration time for PPIs, except for the immediate-release formulation of omeprazole?

Before a meal Signup and view all the answers

Which of the following drugs may interact significantly with PPIs metabolized by the cytochrome P450 system?

Omeprazole Signup and view all the answers

What is the mechanism behind rebound gastric acid hypersecretion after discontinuation of PPIs?

Gastrin-induced hyperplasia and hypertrophy of histamine-secreting ECL cells Signup and view all the answers

Which of the following is a potential side effect of long-term use of PPIs?

Increased risk of iron deficiency Signup and view all the answers

What effect can PPIs have on the antiplatelet effect of clopidogrel?

Reduce the antiplatelet effect Signup and view all the answers

What is the suggested approach for patients needing to take PPIs long term?

Check a complete blood count, vitamin B12 level, and magnesium level Signup and view all the answers

What is the potential advantage of pantoprazole over other PPIs?

Lower risk of drug interaction with clopidogrel Signup and view all the answers