Probing PPIs
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Questions and Answers

Which of the following is the mainstay of treatment for peptic ulcer disease?

  • Eradication of H. pylori (correct)
  • Antacids
  • NSAIDs
  • Histamine inhibitors

What is the primary therapeutic agent for peptic ulcers?

  • Eradication of H. pylori (correct)
  • Histamine inhibitors
  • NSAIDs
  • Antacids

Which of the following antacids should not be used in chronic renal failure patients?

  • Sodium bicarbonate
  • Calcium carbonate
  • Magnesium hydroxide (correct)
  • Aluminum hydroxide

Which of the following H2 receptor antagonists is known to have weak antiandrogenic side effects?

<p>Cimetidine (B)</p> Signup and view all the answers

Which of the following H2 receptor antagonists was taken off the market due to contamination with a known carcinogen?

<p>Ranitidine (B)</p> Signup and view all the answers

Which of the following proton pump inhibitors is available as a parenteral formulation for intravenous use?

<p>Pantoprazole (C)</p> Signup and view all the answers

Which of the following proton pump inhibitors is the S-enantiomer of omeprazole?

<p>Esomeprazole (C)</p> Signup and view all the answers

Which of the following is NOT a concern raised about the widespread use of antibiotics for H. pylori therapy?

<p>Decreased efficacy (B)</p> Signup and view all the answers

What is the recommended duration for combination therapy for H. pylori?

<p>14 days (C)</p> Signup and view all the answers

Which of the following is NOT mentioned as one of the agents used frequently in H. pylori therapy?

<p>Ciprofloxacin (B)</p> Signup and view all the answers

Which class of agents inhibits gastric acid secretion via potassium competitive binding of the H+,K+-ATPase?

<p>P-CAPs (B)</p> Signup and view all the answers

Which agent has been awarded Fast Track status by the FDA for the treatment of H. pylori in combination with antibiotics?

<p>Vonoprazan (D)</p> Signup and view all the answers

What is the most common toxicity noted with prostaglandin analogues?

<p>Diarrhea (B)</p> Signup and view all the answers

Which drug should be avoided in patients with chronic renal insufficiency to prevent aluminum-induced neurotoxicity?

<p>Sucralfate (B)</p> Signup and view all the answers

Which of the following is NOT a potential side effect of long-term use of PPIs?

<p>Gastric acid hypersecretion (C)</p> Signup and view all the answers

What is the recommended administration time for PPIs, except for the immediate-release formulation of omeprazole?

<p>Before a meal (D)</p> Signup and view all the answers

Which of the following drugs may interact significantly with PPIs metabolized by the cytochrome P450 system?

<p>Omeprazole (D)</p> Signup and view all the answers

What is the mechanism behind rebound gastric acid hypersecretion after discontinuation of PPIs?

<p>Gastrin-induced hyperplasia and hypertrophy of histamine-secreting ECL cells (A)</p> Signup and view all the answers

Which of the following is a potential side effect of long-term use of PPIs?

<p>Increased risk of iron deficiency (C)</p> Signup and view all the answers

What effect can PPIs have on the antiplatelet effect of clopidogrel?

<p>Reduce the antiplatelet effect (B)</p> Signup and view all the answers

What is the suggested approach for patients needing to take PPIs long term?

<p>Check a complete blood count, vitamin B12 level, and magnesium level (B)</p> Signup and view all the answers

What is the potential advantage of pantoprazole over other PPIs?

<p>Lower risk of drug interaction with clopidogrel (D)</p> Signup and view all the answers

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