14 Questions
What are some of the different types of PrD mentioned in the passage?
The passage mentions Creutzfeldt-Jacob, kuru, iatrogenic, and genetic diseases such as fatal familial insomnia and genetic Creutzfeldt-Jacob and Gerstmann-Strussler Scheinker syndrome.
Why can it be challenging to diagnose PrD?
It can be challenging to diagnose PrD due to the lack of specific tests.
What are the main characteristics of transmissible spongiform encephalopathies (PrD)?
PrD are manifested by the misfolding of prion proteins within brain cells, resulting in ballooned neurons. They can lead to myoclonus, parkinsonian features, and rapidly progressive dementia.
What are the clinical findings typically associated with PrD?
myoclonus, parkinsonian features, rapidly progressive dementia
What have clinicians developed to facilitate the clinical diagnosis of PrD?
Diagnostic criteria have been developed to facilitate clinical diagnosis for clinicians.
What happens within brain cells in PrD that leads to the manifestation of the disease?
accumulation of misfolding prion proteins
Name two genetic diseases that fall under the category of PrD.
fatal familial insomnia, genetic Creutzfeldt-Jacob
Why is diagnosing PrD challenging for clinicians?
lack of specific tests
What is the common factor among different types of PrD mentioned in the passage?
misfolding prion proteins
Explain the mechanism by which misfolded prion proteins lead to the manifestation of PrD.
Misfolded prion proteins accumulate within brain cells, resulting in ballooned neurons, which leads to the manifestation of PrD.
What is the significance of the term 'transmissible' in the context of PrD?
The term 'transmissible' implies that PrD can be transmitted or passed on from one individual to another.
Explain the potential challenges in diagnosing PrD and the need for diagnostic criteria.
PrD can be challenging to diagnose due to the lack of specific tests, which necessitates the development of diagnostic criteria to facilitate clinical diagnosis.
What is the significance of the term 'spongiform' in the context of PrD?
The term 'spongiform' refers to the sponge-like appearance of the brain tissue in PrD, likely due to the ballooned neurons.
Discuss the potential implications of the rapidly progressive nature of PrD mentioned in the passage.
The rapidly progressive nature of PrD, as mentioned in the passage, implies that the disease progresses quickly, potentially leading to severe consequences and the need for prompt diagnosis and treatment.
Test your knowledge on the manifestations of transmissible spongiform encephalopathies caused by misfolded prion proteins. Learn about the different types of prion diseases such as Creutzfeldt-Jacob, kuru, fatal familial insomnia, and Gerstmann-Sträussler Scheinker syndrome.
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